Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/247682 |
Resumo: | Objective: The aim of the present study is to investigate embryo quality (score) after controlled ovarian stimulation for IVF using rFSH or hMG with the GnRH antagonist protocol. Methods: Open, randomized, single center study. The patients were randomized to receive rFSH or hMG according to randomized cards inside a black envelope with the name of the respective treatment following a computer generated list (85 patients were allocated to rFSH group and 83 patients to hMG group). Inclusion criteria were patients with IVF indication and normal ovarian reserve. Embryo evaluation was performed on day three, after fertilization based on the Graduated Embryo Score (GES). Results: There were no relevant differences in demographic characteristics. There was no difference in pregnancy rates with 27 (31%) and 25 (30.1%) pregnancies for rFSH and hMG, respectively (p=0.87). The total embryo score was the same for both groups, but the best embryo score was significant higher for the rFSH group (77.33±34.0 x 65.07±33.2 p=0.03). The total number of embryos was statistical different, also in favor of the rFSH group (4.17±3.1 x 3.26±2.4 p=0.04). Conclusion: The total embryo score was the same for both groups, but the best embryo score was significantly higher for the rFSH group. Moreover, rFSH was associated with an increased number of embryos. |
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Chapon, Rita de Cassia BorgesGenro, Vanessa KrebsSouza, Carlos Augusto Bastos deCunha Filho, João Sabino Lahorgue da2022-08-21T04:39:41Z20211518-0557http://hdl.handle.net/10183/247682001148065Objective: The aim of the present study is to investigate embryo quality (score) after controlled ovarian stimulation for IVF using rFSH or hMG with the GnRH antagonist protocol. Methods: Open, randomized, single center study. The patients were randomized to receive rFSH or hMG according to randomized cards inside a black envelope with the name of the respective treatment following a computer generated list (85 patients were allocated to rFSH group and 83 patients to hMG group). Inclusion criteria were patients with IVF indication and normal ovarian reserve. Embryo evaluation was performed on day three, after fertilization based on the Graduated Embryo Score (GES). Results: There were no relevant differences in demographic characteristics. There was no difference in pregnancy rates with 27 (31%) and 25 (30.1%) pregnancies for rFSH and hMG, respectively (p=0.87). The total embryo score was the same for both groups, but the best embryo score was significant higher for the rFSH group (77.33±34.0 x 65.07±33.2 p=0.03). The total number of embryos was statistical different, also in favor of the rFSH group (4.17±3.1 x 3.26±2.4 p=0.04). Conclusion: The total embryo score was the same for both groups, but the best embryo score was significantly higher for the rFSH group. Moreover, rFSH was associated with an increased number of embryos.application/pdfengJBRA assisted reproduction. Brasília. Vol. 24, no. 1 (2021), p. 131-135Fertilização in vitroHormônio foliculoestimulante humanoMenotropinasGonadotropinasEstruturas embrionáriasIn vitro fertilizationrFSHhMGGnRH antagonistEmbryonic qualityRandomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonistinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001148065.pdf.txt001148065.pdf.txtExtracted Texttext/plain23491http://www.lume.ufrgs.br/bitstream/10183/247682/2/001148065.pdf.txt67422eb78937fd15194e333ecff974d3MD52ORIGINAL001148065.pdfTexto completo (inglês)application/pdf581112http://www.lume.ufrgs.br/bitstream/10183/247682/1/001148065.pdf72c3c987b843e01e8356d543c85d815aMD5110183/2476822022-08-22 04:35:17.199841oai:www.lume.ufrgs.br:10183/247682Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-08-22T07:35:17Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist |
title |
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist |
spellingShingle |
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist Chapon, Rita de Cassia Borges Fertilização in vitro Hormônio foliculoestimulante humano Menotropinas Gonadotropinas Estruturas embrionárias In vitro fertilization rFSH hMG GnRH antagonist Embryonic quality |
title_short |
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist |
title_full |
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist |
title_fullStr |
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist |
title_full_unstemmed |
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist |
title_sort |
Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist |
author |
Chapon, Rita de Cassia Borges |
author_facet |
Chapon, Rita de Cassia Borges Genro, Vanessa Krebs Souza, Carlos Augusto Bastos de Cunha Filho, João Sabino Lahorgue da |
author_role |
author |
author2 |
Genro, Vanessa Krebs Souza, Carlos Augusto Bastos de Cunha Filho, João Sabino Lahorgue da |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Chapon, Rita de Cassia Borges Genro, Vanessa Krebs Souza, Carlos Augusto Bastos de Cunha Filho, João Sabino Lahorgue da |
dc.subject.por.fl_str_mv |
Fertilização in vitro Hormônio foliculoestimulante humano Menotropinas Gonadotropinas Estruturas embrionárias |
topic |
Fertilização in vitro Hormônio foliculoestimulante humano Menotropinas Gonadotropinas Estruturas embrionárias In vitro fertilization rFSH hMG GnRH antagonist Embryonic quality |
dc.subject.eng.fl_str_mv |
In vitro fertilization rFSH hMG GnRH antagonist Embryonic quality |
description |
Objective: The aim of the present study is to investigate embryo quality (score) after controlled ovarian stimulation for IVF using rFSH or hMG with the GnRH antagonist protocol. Methods: Open, randomized, single center study. The patients were randomized to receive rFSH or hMG according to randomized cards inside a black envelope with the name of the respective treatment following a computer generated list (85 patients were allocated to rFSH group and 83 patients to hMG group). Inclusion criteria were patients with IVF indication and normal ovarian reserve. Embryo evaluation was performed on day three, after fertilization based on the Graduated Embryo Score (GES). Results: There were no relevant differences in demographic characteristics. There was no difference in pregnancy rates with 27 (31%) and 25 (30.1%) pregnancies for rFSH and hMG, respectively (p=0.87). The total embryo score was the same for both groups, but the best embryo score was significant higher for the rFSH group (77.33±34.0 x 65.07±33.2 p=0.03). The total number of embryos was statistical different, also in favor of the rFSH group (4.17±3.1 x 3.26±2.4 p=0.04). Conclusion: The total embryo score was the same for both groups, but the best embryo score was significantly higher for the rFSH group. Moreover, rFSH was associated with an increased number of embryos. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-08-21T04:39:41Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/247682 |
dc.identifier.issn.pt_BR.fl_str_mv |
1518-0557 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001148065 |
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1518-0557 001148065 |
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http://hdl.handle.net/10183/247682 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
JBRA assisted reproduction. Brasília. Vol. 24, no. 1 (2021), p. 131-135 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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