Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder

Detalhes bibliográficos
Autor(a) principal: Kauer-Sant'Anna, Márcia
Data de Publicação: 2009
Outros Autores: Kapczinski, Flávio Pereira, Andreazza, Ana Cristina, Bond, David J., Lam, Raymond W., Young, L. Trevor, Yatham, Lakshmi N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/148544
Resumo: Bipolar I disorder (BD) has a poorer longer-term outcome than previously thought, with persistent cognitive impairment and functional decline. The neurobiological underpinnings that might underlie these changes remain unknown. Changes in brain-derived neurotrophic factor (BDNF) levels and cytokines are potential candidates. The aim of this study was to examine both cytokine and BDNF levels and their relationship in BD patients in the early and late stages of the disorder. We measured serum BDNF, TNF-a, IL-6 and IL-10 levels in a total of 60 patients with BD I and we compared those in early stages of illness with those in late stages of illness and also compared both groups with 60 matched healthy controls. BDNF was decreased only in those patients in the late stage of bipolar disorder. Moreover, BDNF levels were negatively correlated with length of illness. In contrast, all interleukins and TNF-a were increased in the early stages of BD, compared to controls. While TNF-a and IL-6 continued to be significantly higher than controls at late stages of BD, IL-10 did not. When levels were compared between patients at early and late stages of illness, there was a significant decrease in BDNF and IL-6 in the later stage of BD compared to the early stage. Inversely, TNF-a showed a significant increase at the later stage. Failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these may have the potential to serve as markers of illness progression in BD.
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spelling Kauer-Sant'Anna, MárciaKapczinski, Flávio PereiraAndreazza, Ana CristinaBond, David J.Lam, Raymond W.Young, L. TrevorYatham, Lakshmi N.2016-09-27T02:14:35Z20091461-1457http://hdl.handle.net/10183/148544000722686Bipolar I disorder (BD) has a poorer longer-term outcome than previously thought, with persistent cognitive impairment and functional decline. The neurobiological underpinnings that might underlie these changes remain unknown. Changes in brain-derived neurotrophic factor (BDNF) levels and cytokines are potential candidates. The aim of this study was to examine both cytokine and BDNF levels and their relationship in BD patients in the early and late stages of the disorder. We measured serum BDNF, TNF-a, IL-6 and IL-10 levels in a total of 60 patients with BD I and we compared those in early stages of illness with those in late stages of illness and also compared both groups with 60 matched healthy controls. BDNF was decreased only in those patients in the late stage of bipolar disorder. Moreover, BDNF levels were negatively correlated with length of illness. In contrast, all interleukins and TNF-a were increased in the early stages of BD, compared to controls. While TNF-a and IL-6 continued to be significantly higher than controls at late stages of BD, IL-10 did not. When levels were compared between patients at early and late stages of illness, there was a significant decrease in BDNF and IL-6 in the later stage of BD compared to the early stage. Inversely, TNF-a showed a significant increase at the later stage. Failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these may have the potential to serve as markers of illness progression in BD.application/pdfengInternational journal of neuropsychopharmacology. Cambridge. Vol. 12, no. 4 (2009), p. 447-458Transtorno bipolarFator neurotrófico derivado do encéfaloCitocinasInterleucinasFator de necrose tumoral alfaPsicopatologiaTranstornos mentaisBipolar disorderBDNFCytokinesFirst episodeInterleukinsTNF-aBrain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorderEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000722686.pdf000722686.pdfTexto completo (inglês)application/pdf135291http://www.lume.ufrgs.br/bitstream/10183/148544/1/000722686.pdf2e6f7a99a65f9ab81ba9a03159d0d6c9MD51TEXT000722686.pdf.txt000722686.pdf.txtExtracted Texttext/plain53133http://www.lume.ufrgs.br/bitstream/10183/148544/2/000722686.pdf.txt6a1d1fb3ea3e6f381872c2663da0bdbbMD52THUMBNAIL000722686.pdf.jpg000722686.pdf.jpgGenerated Thumbnailimage/jpeg1796http://www.lume.ufrgs.br/bitstream/10183/148544/3/000722686.pdf.jpg9d4debeb0537fccdfef9a9270109a8baMD5310183/1485442018-10-29 08:59:03.499oai:www.lume.ufrgs.br:10183/148544Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-29T11:59:03Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
title Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
spellingShingle Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
Kauer-Sant'Anna, Márcia
Transtorno bipolar
Fator neurotrófico derivado do encéfalo
Citocinas
Interleucinas
Fator de necrose tumoral alfa
Psicopatologia
Transtornos mentais
Bipolar disorder
BDNF
Cytokines
First episode
Interleukins
TNF-a
title_short Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
title_full Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
title_fullStr Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
title_full_unstemmed Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
title_sort Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
author Kauer-Sant'Anna, Márcia
author_facet Kauer-Sant'Anna, Márcia
Kapczinski, Flávio Pereira
Andreazza, Ana Cristina
Bond, David J.
Lam, Raymond W.
Young, L. Trevor
Yatham, Lakshmi N.
author_role author
author2 Kapczinski, Flávio Pereira
Andreazza, Ana Cristina
Bond, David J.
Lam, Raymond W.
Young, L. Trevor
Yatham, Lakshmi N.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kauer-Sant'Anna, Márcia
Kapczinski, Flávio Pereira
Andreazza, Ana Cristina
Bond, David J.
Lam, Raymond W.
Young, L. Trevor
Yatham, Lakshmi N.
dc.subject.por.fl_str_mv Transtorno bipolar
Fator neurotrófico derivado do encéfalo
Citocinas
Interleucinas
Fator de necrose tumoral alfa
Psicopatologia
Transtornos mentais
topic Transtorno bipolar
Fator neurotrófico derivado do encéfalo
Citocinas
Interleucinas
Fator de necrose tumoral alfa
Psicopatologia
Transtornos mentais
Bipolar disorder
BDNF
Cytokines
First episode
Interleukins
TNF-a
dc.subject.eng.fl_str_mv Bipolar disorder
BDNF
Cytokines
First episode
Interleukins
TNF-a
description Bipolar I disorder (BD) has a poorer longer-term outcome than previously thought, with persistent cognitive impairment and functional decline. The neurobiological underpinnings that might underlie these changes remain unknown. Changes in brain-derived neurotrophic factor (BDNF) levels and cytokines are potential candidates. The aim of this study was to examine both cytokine and BDNF levels and their relationship in BD patients in the early and late stages of the disorder. We measured serum BDNF, TNF-a, IL-6 and IL-10 levels in a total of 60 patients with BD I and we compared those in early stages of illness with those in late stages of illness and also compared both groups with 60 matched healthy controls. BDNF was decreased only in those patients in the late stage of bipolar disorder. Moreover, BDNF levels were negatively correlated with length of illness. In contrast, all interleukins and TNF-a were increased in the early stages of BD, compared to controls. While TNF-a and IL-6 continued to be significantly higher than controls at late stages of BD, IL-10 did not. When levels were compared between patients at early and late stages of illness, there was a significant decrease in BDNF and IL-6 in the later stage of BD compared to the early stage. Inversely, TNF-a showed a significant increase at the later stage. Failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these may have the potential to serve as markers of illness progression in BD.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2016-09-27T02:14:35Z
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dc.identifier.issn.pt_BR.fl_str_mv 1461-1457
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dc.relation.ispartof.pt_BR.fl_str_mv International journal of neuropsychopharmacology. Cambridge. Vol. 12, no. 4 (2009), p. 447-458
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