Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/148544 |
Resumo: | Bipolar I disorder (BD) has a poorer longer-term outcome than previously thought, with persistent cognitive impairment and functional decline. The neurobiological underpinnings that might underlie these changes remain unknown. Changes in brain-derived neurotrophic factor (BDNF) levels and cytokines are potential candidates. The aim of this study was to examine both cytokine and BDNF levels and their relationship in BD patients in the early and late stages of the disorder. We measured serum BDNF, TNF-a, IL-6 and IL-10 levels in a total of 60 patients with BD I and we compared those in early stages of illness with those in late stages of illness and also compared both groups with 60 matched healthy controls. BDNF was decreased only in those patients in the late stage of bipolar disorder. Moreover, BDNF levels were negatively correlated with length of illness. In contrast, all interleukins and TNF-a were increased in the early stages of BD, compared to controls. While TNF-a and IL-6 continued to be significantly higher than controls at late stages of BD, IL-10 did not. When levels were compared between patients at early and late stages of illness, there was a significant decrease in BDNF and IL-6 in the later stage of BD compared to the early stage. Inversely, TNF-a showed a significant increase at the later stage. Failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these may have the potential to serve as markers of illness progression in BD. |
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Kauer-Sant'Anna, MárciaKapczinski, Flávio PereiraAndreazza, Ana CristinaBond, David J.Lam, Raymond W.Young, L. TrevorYatham, Lakshmi N.2016-09-27T02:14:35Z20091461-1457http://hdl.handle.net/10183/148544000722686Bipolar I disorder (BD) has a poorer longer-term outcome than previously thought, with persistent cognitive impairment and functional decline. The neurobiological underpinnings that might underlie these changes remain unknown. Changes in brain-derived neurotrophic factor (BDNF) levels and cytokines are potential candidates. The aim of this study was to examine both cytokine and BDNF levels and their relationship in BD patients in the early and late stages of the disorder. We measured serum BDNF, TNF-a, IL-6 and IL-10 levels in a total of 60 patients with BD I and we compared those in early stages of illness with those in late stages of illness and also compared both groups with 60 matched healthy controls. BDNF was decreased only in those patients in the late stage of bipolar disorder. Moreover, BDNF levels were negatively correlated with length of illness. In contrast, all interleukins and TNF-a were increased in the early stages of BD, compared to controls. While TNF-a and IL-6 continued to be significantly higher than controls at late stages of BD, IL-10 did not. When levels were compared between patients at early and late stages of illness, there was a significant decrease in BDNF and IL-6 in the later stage of BD compared to the early stage. Inversely, TNF-a showed a significant increase at the later stage. Failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these may have the potential to serve as markers of illness progression in BD.application/pdfengInternational journal of neuropsychopharmacology. Cambridge. Vol. 12, no. 4 (2009), p. 447-458Transtorno bipolarFator neurotrófico derivado do encéfaloCitocinasInterleucinasFator de necrose tumoral alfaPsicopatologiaTranstornos mentaisBipolar disorderBDNFCytokinesFirst episodeInterleukinsTNF-aBrain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorderEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000722686.pdf000722686.pdfTexto completo (inglês)application/pdf135291http://www.lume.ufrgs.br/bitstream/10183/148544/1/000722686.pdf2e6f7a99a65f9ab81ba9a03159d0d6c9MD51TEXT000722686.pdf.txt000722686.pdf.txtExtracted Texttext/plain53133http://www.lume.ufrgs.br/bitstream/10183/148544/2/000722686.pdf.txt6a1d1fb3ea3e6f381872c2663da0bdbbMD52THUMBNAIL000722686.pdf.jpg000722686.pdf.jpgGenerated Thumbnailimage/jpeg1796http://www.lume.ufrgs.br/bitstream/10183/148544/3/000722686.pdf.jpg9d4debeb0537fccdfef9a9270109a8baMD5310183/1485442018-10-29 08:59:03.499oai:www.lume.ufrgs.br:10183/148544Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-29T11:59:03Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder |
title |
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder |
spellingShingle |
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder Kauer-Sant'Anna, Márcia Transtorno bipolar Fator neurotrófico derivado do encéfalo Citocinas Interleucinas Fator de necrose tumoral alfa Psicopatologia Transtornos mentais Bipolar disorder BDNF Cytokines First episode Interleukins TNF-a |
title_short |
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder |
title_full |
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder |
title_fullStr |
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder |
title_full_unstemmed |
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder |
title_sort |
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder |
author |
Kauer-Sant'Anna, Márcia |
author_facet |
Kauer-Sant'Anna, Márcia Kapczinski, Flávio Pereira Andreazza, Ana Cristina Bond, David J. Lam, Raymond W. Young, L. Trevor Yatham, Lakshmi N. |
author_role |
author |
author2 |
Kapczinski, Flávio Pereira Andreazza, Ana Cristina Bond, David J. Lam, Raymond W. Young, L. Trevor Yatham, Lakshmi N. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Kauer-Sant'Anna, Márcia Kapczinski, Flávio Pereira Andreazza, Ana Cristina Bond, David J. Lam, Raymond W. Young, L. Trevor Yatham, Lakshmi N. |
dc.subject.por.fl_str_mv |
Transtorno bipolar Fator neurotrófico derivado do encéfalo Citocinas Interleucinas Fator de necrose tumoral alfa Psicopatologia Transtornos mentais |
topic |
Transtorno bipolar Fator neurotrófico derivado do encéfalo Citocinas Interleucinas Fator de necrose tumoral alfa Psicopatologia Transtornos mentais Bipolar disorder BDNF Cytokines First episode Interleukins TNF-a |
dc.subject.eng.fl_str_mv |
Bipolar disorder BDNF Cytokines First episode Interleukins TNF-a |
description |
Bipolar I disorder (BD) has a poorer longer-term outcome than previously thought, with persistent cognitive impairment and functional decline. The neurobiological underpinnings that might underlie these changes remain unknown. Changes in brain-derived neurotrophic factor (BDNF) levels and cytokines are potential candidates. The aim of this study was to examine both cytokine and BDNF levels and their relationship in BD patients in the early and late stages of the disorder. We measured serum BDNF, TNF-a, IL-6 and IL-10 levels in a total of 60 patients with BD I and we compared those in early stages of illness with those in late stages of illness and also compared both groups with 60 matched healthy controls. BDNF was decreased only in those patients in the late stage of bipolar disorder. Moreover, BDNF levels were negatively correlated with length of illness. In contrast, all interleukins and TNF-a were increased in the early stages of BD, compared to controls. While TNF-a and IL-6 continued to be significantly higher than controls at late stages of BD, IL-10 did not. When levels were compared between patients at early and late stages of illness, there was a significant decrease in BDNF and IL-6 in the later stage of BD compared to the early stage. Inversely, TNF-a showed a significant increase at the later stage. Failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these may have the potential to serve as markers of illness progression in BD. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2016-09-27T02:14:35Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/148544 |
dc.identifier.issn.pt_BR.fl_str_mv |
1461-1457 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000722686 |
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1461-1457 000722686 |
url |
http://hdl.handle.net/10183/148544 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International journal of neuropsychopharmacology. Cambridge. Vol. 12, no. 4 (2009), p. 447-458 |
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openAccess |
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