Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

Detalhes bibliográficos
Autor(a) principal: Demontis, Ditte
Data de Publicação: 2021
Outros Autores: Bau, Claiton Henrique Dotto, Grevet, Eugenio Horácio, Rohde, Luis Augusto Paim, Børglum, Anders Dupont
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/252586
Resumo: Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.
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spelling Demontis, DitteBau, Claiton Henrique DottoGrevet, Eugenio HorácioRohde, Luis Augusto PaimBørglum, Anders Dupont2022-12-09T05:00:10Z20212041-1723http://hdl.handle.net/10183/252586001154562Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.application/pdfengNature Communications. London. Vol. 12 (2021), 576, 12 p.Transtorno do déficit de atenção com hiperatividadeTranstornos de déficit da atenção e do comportamento disruptivoEstudo de associação genômica amplaGenome-wide association studiesADHDRisk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorderEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001154562.pdf.txt001154562.pdf.txtExtracted Texttext/plain86541http://www.lume.ufrgs.br/bitstream/10183/252586/2/001154562.pdf.txta948efb735a68275987634c5d43826c8MD52ORIGINAL001154562.pdfTexto completo (inglês)application/pdf1023511http://www.lume.ufrgs.br/bitstream/10183/252586/1/001154562.pdf1395299d409af4a6502d58c218f7bc9cMD5110183/2525862022-12-10 06:06:56.3081oai:www.lume.ufrgs.br:10183/252586Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2022-12-10T08:06:56Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
spellingShingle Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
Demontis, Ditte
Transtorno do déficit de atenção com hiperatividade
Transtornos de déficit da atenção e do comportamento disruptivo
Estudo de associação genômica ampla
Genome-wide association studies
ADHD
title_short Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_full Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_fullStr Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_full_unstemmed Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_sort Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
author Demontis, Ditte
author_facet Demontis, Ditte
Bau, Claiton Henrique Dotto
Grevet, Eugenio Horácio
Rohde, Luis Augusto Paim
Børglum, Anders Dupont
author_role author
author2 Bau, Claiton Henrique Dotto
Grevet, Eugenio Horácio
Rohde, Luis Augusto Paim
Børglum, Anders Dupont
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Demontis, Ditte
Bau, Claiton Henrique Dotto
Grevet, Eugenio Horácio
Rohde, Luis Augusto Paim
Børglum, Anders Dupont
dc.subject.por.fl_str_mv Transtorno do déficit de atenção com hiperatividade
Transtornos de déficit da atenção e do comportamento disruptivo
Estudo de associação genômica ampla
topic Transtorno do déficit de atenção com hiperatividade
Transtornos de déficit da atenção e do comportamento disruptivo
Estudo de associação genômica ampla
Genome-wide association studies
ADHD
dc.subject.eng.fl_str_mv Genome-wide association studies
ADHD
description Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-12-09T05:00:10Z
dc.type.driver.fl_str_mv Estrangeiro
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/252586
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dc.identifier.nrb.pt_BR.fl_str_mv 001154562
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Nature Communications. London. Vol. 12 (2021), 576, 12 p.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
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