Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/234504 |
Resumo: | Acute lymphoid leukemia is a childhood cancer that in high‑income countries has event‑free survival rates of 80% and global survival rates of 90%. In Brazil these rates are under 70%. This difference may be due to the implementation of supportive care, including the assessment of asparaginase (ASNase) activity. ASNase may cause hypersensitivity reactions and silent drug inactivation. For this reason, ASNase activity monitoring is an essential tool to ensure an effective treatment. Our aim was to implement an ASNase activity measurement technique at a hospital setting. samples from children who were given Escherichia coli‑derived ASNase were collected. The results of the analyses conducted in our laboratory Hospital de Clínicas de Porto Alegre were compared to those of two institutions: Centro Infantil Boldrini and University of Munster. 262 samples were assessed. The results of the first analyses were compared with those obtained at Centro Infantil Boldrini and showed an ICC of 0.954. Thirty samples were sent to the University of Munster and presented an ICC was 0.960. Our results, when compared to those of national and international centers, showed an excellent agreement. The study was able to implement an ASNase activity test to monitor the treatment. |
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Cecconello, Daiane KellerRechenmacher, CilianaWerlang, Isabel Cristina RibasZenatti, Priscila PiniYunes, José AndrésAlegretti, Ana PaulaKaminsky, Claudia LanversDaudt, Liane EstevesMichalowski, Mariana Bohns2022-01-27T04:32:20Z20202045-2322http://hdl.handle.net/10183/234504001135911Acute lymphoid leukemia is a childhood cancer that in high‑income countries has event‑free survival rates of 80% and global survival rates of 90%. In Brazil these rates are under 70%. This difference may be due to the implementation of supportive care, including the assessment of asparaginase (ASNase) activity. ASNase may cause hypersensitivity reactions and silent drug inactivation. For this reason, ASNase activity monitoring is an essential tool to ensure an effective treatment. Our aim was to implement an ASNase activity measurement technique at a hospital setting. samples from children who were given Escherichia coli‑derived ASNase were collected. The results of the analyses conducted in our laboratory Hospital de Clínicas de Porto Alegre were compared to those of two institutions: Centro Infantil Boldrini and University of Munster. 262 samples were assessed. The results of the first analyses were compared with those obtained at Centro Infantil Boldrini and showed an ICC of 0.954. Thirty samples were sent to the University of Munster and presented an ICC was 0.960. Our results, when compared to those of national and international centers, showed an excellent agreement. The study was able to implement an ASNase activity test to monitor the treatment.application/pdfengScientific reports. London. Vol. 10 (2020), 21481, [6 p.]Leucemia-linfoma linfoblástico de células precursorasAsparaginaseAvaliação de resultados da assistência ao pacienteImplementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian CenterEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001135911.pdf.txt001135911.pdf.txtExtracted Texttext/plain24512http://www.lume.ufrgs.br/bitstream/10183/234504/2/001135911.pdf.txtc4e8a2ea480f93da4fa656bf174fafcbMD52ORIGINAL001135911.pdfTexto completo (inglês)application/pdf935271http://www.lume.ufrgs.br/bitstream/10183/234504/1/001135911.pdf134d0ce4fbeb3f555bf6ec336f032a78MD5110183/2345042022-05-24 04:44:29.842344oai:www.lume.ufrgs.br:10183/234504Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-05-24T07:44:29Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center |
title |
Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center |
spellingShingle |
Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center Cecconello, Daiane Keller Leucemia-linfoma linfoblástico de células precursoras Asparaginase Avaliação de resultados da assistência ao paciente |
title_short |
Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center |
title_full |
Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center |
title_fullStr |
Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center |
title_full_unstemmed |
Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center |
title_sort |
Implementation of the asparaginase activity assessment technique for clinical use : experience of a Brazilian Center |
author |
Cecconello, Daiane Keller |
author_facet |
Cecconello, Daiane Keller Rechenmacher, Ciliana Werlang, Isabel Cristina Ribas Zenatti, Priscila Pini Yunes, José Andrés Alegretti, Ana Paula Kaminsky, Claudia Lanvers Daudt, Liane Esteves Michalowski, Mariana Bohns |
author_role |
author |
author2 |
Rechenmacher, Ciliana Werlang, Isabel Cristina Ribas Zenatti, Priscila Pini Yunes, José Andrés Alegretti, Ana Paula Kaminsky, Claudia Lanvers Daudt, Liane Esteves Michalowski, Mariana Bohns |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cecconello, Daiane Keller Rechenmacher, Ciliana Werlang, Isabel Cristina Ribas Zenatti, Priscila Pini Yunes, José Andrés Alegretti, Ana Paula Kaminsky, Claudia Lanvers Daudt, Liane Esteves Michalowski, Mariana Bohns |
dc.subject.por.fl_str_mv |
Leucemia-linfoma linfoblástico de células precursoras Asparaginase Avaliação de resultados da assistência ao paciente |
topic |
Leucemia-linfoma linfoblástico de células precursoras Asparaginase Avaliação de resultados da assistência ao paciente |
description |
Acute lymphoid leukemia is a childhood cancer that in high‑income countries has event‑free survival rates of 80% and global survival rates of 90%. In Brazil these rates are under 70%. This difference may be due to the implementation of supportive care, including the assessment of asparaginase (ASNase) activity. ASNase may cause hypersensitivity reactions and silent drug inactivation. For this reason, ASNase activity monitoring is an essential tool to ensure an effective treatment. Our aim was to implement an ASNase activity measurement technique at a hospital setting. samples from children who were given Escherichia coli‑derived ASNase were collected. The results of the analyses conducted in our laboratory Hospital de Clínicas de Porto Alegre were compared to those of two institutions: Centro Infantil Boldrini and University of Munster. 262 samples were assessed. The results of the first analyses were compared with those obtained at Centro Infantil Boldrini and showed an ICC of 0.954. Thirty samples were sent to the University of Munster and presented an ICC was 0.960. Our results, when compared to those of national and international centers, showed an excellent agreement. The study was able to implement an ASNase activity test to monitor the treatment. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
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2022-01-27T04:32:20Z |
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http://hdl.handle.net/10183/234504 |
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2045-2322 |
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001135911 |
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Scientific reports. London. Vol. 10 (2020), 21481, [6 p.] |
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