Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/148403 |
Resumo: | Systemic toxicity is a relevant dimension of pathophysiology in bipolar disorder, and oxidative damage is one potential link between central and peripheral pathology. Although there is mounting evidence that chronic bipolar disorder is associated with oxidative stress, studies in the early stages of bipolar disorder are scarce, and heavily reliant on clinical in lieu of population studies. The objective of this study was to confirm leading hypotheses about the role of oxidative damage in bipolar disorder. To that end, we nested a case-control study in a population-based study of young adults aged 18–24 yr. After an initial psychopathology screen, all people with a lifetime history of (hypo)mania and matched controls underwent a structured diagnostic interview. This yielded a sample of 231 participants, in whom we measured serum protein carbonyl content (PCC) and thiobarbituric acid reactive substances (TBARS). People with bipolar disorder had higher PCC levels than healthy subjects. Those with major depression were not different from control subjects in either PCC or TBARS levels. Both bipolar disorder and major depression were associated with higher PCC levels in the a priori regression model controlling for possible confounders. These findings indicate that protein oxidative damage is present from early stages and can be seen as a sign of early illness activity in mood disorders. |
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Magalhães, Pedro Vieira da SilvaJansen, KarenPinheiro, Ricardo TavaresColpo, Gabriela DelevatiMotta, Leonardo Lisbôa daKlamt, FabioSilva, Ricardo Azevedo daKapczinski, Flávio Pereira2016-09-27T02:13:17Z20121461-1457http://hdl.handle.net/10183/148403000856042Systemic toxicity is a relevant dimension of pathophysiology in bipolar disorder, and oxidative damage is one potential link between central and peripheral pathology. Although there is mounting evidence that chronic bipolar disorder is associated with oxidative stress, studies in the early stages of bipolar disorder are scarce, and heavily reliant on clinical in lieu of population studies. The objective of this study was to confirm leading hypotheses about the role of oxidative damage in bipolar disorder. To that end, we nested a case-control study in a population-based study of young adults aged 18–24 yr. After an initial psychopathology screen, all people with a lifetime history of (hypo)mania and matched controls underwent a structured diagnostic interview. This yielded a sample of 231 participants, in whom we measured serum protein carbonyl content (PCC) and thiobarbituric acid reactive substances (TBARS). People with bipolar disorder had higher PCC levels than healthy subjects. Those with major depression were not different from control subjects in either PCC or TBARS levels. Both bipolar disorder and major depression were associated with higher PCC levels in the a priori regression model controlling for possible confounders. These findings indicate that protein oxidative damage is present from early stages and can be seen as a sign of early illness activity in mood disorders.application/pdfengInternational journal of neuropsychopharmacology. Cambridge. Vol. 15, no. 8 (Sep. 2012), p. 1043-1050Transtorno bipolarDepressãoEstresse oxidativoCarbonilação proteicaSubstâncias reativas com ácido tiobarbitúricoBipolar disorderMajor depressionOxidative stressPopulation-based studyProtein carbonyl contentThiobarbituric acid reactive substancesPeripheral oxidative damage in early-stage mood disorders : a nested population-based case-control studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000856042.pdf000856042.pdfTexto completo (inglês)application/pdf111941http://www.lume.ufrgs.br/bitstream/10183/148403/1/000856042.pdf52fe9e3eabf9ebe765ccb5cbe400a516MD51TEXT000856042.pdf.txt000856042.pdf.txtExtracted Texttext/plain35846http://www.lume.ufrgs.br/bitstream/10183/148403/2/000856042.pdf.txtdc0b31bcfd5fa34e2393ba70c5a9ffa8MD52THUMBNAIL000856042.pdf.jpg000856042.pdf.jpgGenerated Thumbnailimage/jpeg1800http://www.lume.ufrgs.br/bitstream/10183/148403/3/000856042.pdf.jpg0c5ad25f68aaffd18ff3a55a047c173dMD5310183/1484032019-01-11 04:09:08.676982oai:www.lume.ufrgs.br:10183/148403Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-01-11T06:09:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study |
title |
Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study |
spellingShingle |
Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study Magalhães, Pedro Vieira da Silva Transtorno bipolar Depressão Estresse oxidativo Carbonilação proteica Substâncias reativas com ácido tiobarbitúrico Bipolar disorder Major depression Oxidative stress Population-based study Protein carbonyl content Thiobarbituric acid reactive substances |
title_short |
Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study |
title_full |
Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study |
title_fullStr |
Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study |
title_full_unstemmed |
Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study |
title_sort |
Peripheral oxidative damage in early-stage mood disorders : a nested population-based case-control study |
author |
Magalhães, Pedro Vieira da Silva |
author_facet |
Magalhães, Pedro Vieira da Silva Jansen, Karen Pinheiro, Ricardo Tavares Colpo, Gabriela Delevati Motta, Leonardo Lisbôa da Klamt, Fabio Silva, Ricardo Azevedo da Kapczinski, Flávio Pereira |
author_role |
author |
author2 |
Jansen, Karen Pinheiro, Ricardo Tavares Colpo, Gabriela Delevati Motta, Leonardo Lisbôa da Klamt, Fabio Silva, Ricardo Azevedo da Kapczinski, Flávio Pereira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Magalhães, Pedro Vieira da Silva Jansen, Karen Pinheiro, Ricardo Tavares Colpo, Gabriela Delevati Motta, Leonardo Lisbôa da Klamt, Fabio Silva, Ricardo Azevedo da Kapczinski, Flávio Pereira |
dc.subject.por.fl_str_mv |
Transtorno bipolar Depressão Estresse oxidativo Carbonilação proteica Substâncias reativas com ácido tiobarbitúrico |
topic |
Transtorno bipolar Depressão Estresse oxidativo Carbonilação proteica Substâncias reativas com ácido tiobarbitúrico Bipolar disorder Major depression Oxidative stress Population-based study Protein carbonyl content Thiobarbituric acid reactive substances |
dc.subject.eng.fl_str_mv |
Bipolar disorder Major depression Oxidative stress Population-based study Protein carbonyl content Thiobarbituric acid reactive substances |
description |
Systemic toxicity is a relevant dimension of pathophysiology in bipolar disorder, and oxidative damage is one potential link between central and peripheral pathology. Although there is mounting evidence that chronic bipolar disorder is associated with oxidative stress, studies in the early stages of bipolar disorder are scarce, and heavily reliant on clinical in lieu of population studies. The objective of this study was to confirm leading hypotheses about the role of oxidative damage in bipolar disorder. To that end, we nested a case-control study in a population-based study of young adults aged 18–24 yr. After an initial psychopathology screen, all people with a lifetime history of (hypo)mania and matched controls underwent a structured diagnostic interview. This yielded a sample of 231 participants, in whom we measured serum protein carbonyl content (PCC) and thiobarbituric acid reactive substances (TBARS). People with bipolar disorder had higher PCC levels than healthy subjects. Those with major depression were not different from control subjects in either PCC or TBARS levels. Both bipolar disorder and major depression were associated with higher PCC levels in the a priori regression model controlling for possible confounders. These findings indicate that protein oxidative damage is present from early stages and can be seen as a sign of early illness activity in mood disorders. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
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2016-09-27T02:13:17Z |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/148403 |
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1461-1457 |
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000856042 |
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http://hdl.handle.net/10183/148403 |
dc.language.iso.fl_str_mv |
eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
International journal of neuropsychopharmacology. Cambridge. Vol. 15, no. 8 (Sep. 2012), p. 1043-1050 |
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openAccess |
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