Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review

• Autor(a) principal: White, Pollyanna A. S.
• Data de Publicação: 2014
• Outros Autores: Oliveira, Rita de Cássia Meneses, Oliveira, Aldeidia Pereira de, Serafini, Mairim Russo, Araujo, Adriano Antunes de Souza, Gelain, Daniel Pens, Moreira, Jose Claudio Fonseca, Almeida, Jackson Roberto Guedes da Silva, Quintans, Jullyana de Souza Siqueira, Quintans Júnior, Lucindo José, Santos, Márcio Roberto Viana dos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/169292
• topic: Líquens; Antioxidantes; Doença crônica; Lichens; Antioxidants; Antioxidant response elements; DPPH; Cancer; Chronic disease

Chronic diseases such as cancer, diabetes, neurodegenerative and cardiovascular diseases are characterized by an enhanced state of oxidative stress, which may result from the overproduction of reactive species and/or a decrease in antioxidant defenses. The search for new chemical entities with antioxidant profile is still thus an emerging field on ongoing interest. Due to the lack of reviews concerning the antioxidant activity of lichen-derived natural compounds, we performed a review of the antioxidant potential and mechanisms of action of natural compounds isolated from lichens. The search terms “lichens”, “antioxidants” and “antioxidant response elements” were used to retrieve articles in LILACS, PubMed and Web of Science published until February 2014. From a total of 319 articles surveyed, 32 met the established inclusion and exclusion criteria. It was observed that the most common isolated compound studied was usnic acid, cited in 14 out of the 32 articles. The most often described antioxidant assays for the study of in vitro antioxidant activity were mainly DPPH, LPO and SOD. The most suggested mechanisms of action were scavenging of reactive species, enzymatic activation and inhibition of iNOS. Thus, compounds isolated from lichens are possible candidates for the management of oxidative stress, and may be useful in the treatment of chronic diseases.