Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/169292 |
Resumo: | Chronic diseases such as cancer, diabetes, neurodegenerative and cardiovascular diseases are characterized by an enhanced state of oxidative stress, which may result from the overproduction of reactive species and/or a decrease in antioxidant defenses. The search for new chemical entities with antioxidant profile is still thus an emerging field on ongoing interest. Due to the lack of reviews concerning the antioxidant activity of lichen-derived natural compounds, we performed a review of the antioxidant potential and mechanisms of action of natural compounds isolated from lichens. The search terms “lichens”, “antioxidants” and “antioxidant response elements” were used to retrieve articles in LILACS, PubMed and Web of Science published until February 2014. From a total of 319 articles surveyed, 32 met the established inclusion and exclusion criteria. It was observed that the most common isolated compound studied was usnic acid, cited in 14 out of the 32 articles. The most often described antioxidant assays for the study of in vitro antioxidant activity were mainly DPPH, LPO and SOD. The most suggested mechanisms of action were scavenging of reactive species, enzymatic activation and inhibition of iNOS. Thus, compounds isolated from lichens are possible candidates for the management of oxidative stress, and may be useful in the treatment of chronic diseases. |
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White, Pollyanna A. S.Oliveira, Rita de Cássia MenesesOliveira, Aldeidia Pereira deSerafini, Mairim RussoAraujo, Adriano Antunes de SouzaGelain, Daniel PensMoreira, Jose Claudio FonsecaAlmeida, Jackson Roberto Guedes da SilvaQuintans, Jullyana de Souza SiqueiraQuintans Júnior, Lucindo JoséSantos, Márcio Roberto Viana dos2017-10-07T05:46:05Z20141420-3049http://hdl.handle.net/10183/169292001048201Chronic diseases such as cancer, diabetes, neurodegenerative and cardiovascular diseases are characterized by an enhanced state of oxidative stress, which may result from the overproduction of reactive species and/or a decrease in antioxidant defenses. The search for new chemical entities with antioxidant profile is still thus an emerging field on ongoing interest. Due to the lack of reviews concerning the antioxidant activity of lichen-derived natural compounds, we performed a review of the antioxidant potential and mechanisms of action of natural compounds isolated from lichens. The search terms “lichens”, “antioxidants” and “antioxidant response elements” were used to retrieve articles in LILACS, PubMed and Web of Science published until February 2014. From a total of 319 articles surveyed, 32 met the established inclusion and exclusion criteria. It was observed that the most common isolated compound studied was usnic acid, cited in 14 out of the 32 articles. The most often described antioxidant assays for the study of in vitro antioxidant activity were mainly DPPH, LPO and SOD. The most suggested mechanisms of action were scavenging of reactive species, enzymatic activation and inhibition of iNOS. Thus, compounds isolated from lichens are possible candidates for the management of oxidative stress, and may be useful in the treatment of chronic diseases.application/pdfengMolecules. Basel, Switzerland. Vol. 19, no. 9 (2014), p. 14496-14527LíquensAntioxidantesDoença crônicaLichensAntioxidantsAntioxidant response elementsDPPHCancerChronic diseaseAntioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic reviewEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001048201.pdf001048201.pdfTexto completo (inglês)application/pdf858023http://www.lume.ufrgs.br/bitstream/10183/169292/1/001048201.pdf2421fa202219465182419ab91f156a13MD51TEXT001048201.pdf.txt001048201.pdf.txtExtracted Texttext/plain86296http://www.lume.ufrgs.br/bitstream/10183/169292/2/001048201.pdf.txt08566e3544da9010f44214b382ce84fdMD52THUMBNAIL001048201.pdf.jpg001048201.pdf.jpgGenerated Thumbnailimage/jpeg2221http://www.lume.ufrgs.br/bitstream/10183/169292/3/001048201.pdf.jpg8377e03a6429348925e06bd71b1aaa1aMD5310183/1692922018-10-29 08:42:26.425oai:www.lume.ufrgs.br:10183/169292Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-29T11:42:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review |
title |
Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review |
spellingShingle |
Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review White, Pollyanna A. S. Líquens Antioxidantes Doença crônica Lichens Antioxidants Antioxidant response elements DPPH Cancer Chronic disease |
title_short |
Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review |
title_full |
Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review |
title_fullStr |
Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review |
title_full_unstemmed |
Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review |
title_sort |
Antioxidant activity and mechanisms of action of natural compounds isolated from lichens : a systematic review |
author |
White, Pollyanna A. S. |
author_facet |
White, Pollyanna A. S. Oliveira, Rita de Cássia Meneses Oliveira, Aldeidia Pereira de Serafini, Mairim Russo Araujo, Adriano Antunes de Souza Gelain, Daniel Pens Moreira, Jose Claudio Fonseca Almeida, Jackson Roberto Guedes da Silva Quintans, Jullyana de Souza Siqueira Quintans Júnior, Lucindo José Santos, Márcio Roberto Viana dos |
author_role |
author |
author2 |
Oliveira, Rita de Cássia Meneses Oliveira, Aldeidia Pereira de Serafini, Mairim Russo Araujo, Adriano Antunes de Souza Gelain, Daniel Pens Moreira, Jose Claudio Fonseca Almeida, Jackson Roberto Guedes da Silva Quintans, Jullyana de Souza Siqueira Quintans Júnior, Lucindo José Santos, Márcio Roberto Viana dos |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
White, Pollyanna A. S. Oliveira, Rita de Cássia Meneses Oliveira, Aldeidia Pereira de Serafini, Mairim Russo Araujo, Adriano Antunes de Souza Gelain, Daniel Pens Moreira, Jose Claudio Fonseca Almeida, Jackson Roberto Guedes da Silva Quintans, Jullyana de Souza Siqueira Quintans Júnior, Lucindo José Santos, Márcio Roberto Viana dos |
dc.subject.por.fl_str_mv |
Líquens Antioxidantes Doença crônica |
topic |
Líquens Antioxidantes Doença crônica Lichens Antioxidants Antioxidant response elements DPPH Cancer Chronic disease |
dc.subject.eng.fl_str_mv |
Lichens Antioxidants Antioxidant response elements DPPH Cancer Chronic disease |
description |
Chronic diseases such as cancer, diabetes, neurodegenerative and cardiovascular diseases are characterized by an enhanced state of oxidative stress, which may result from the overproduction of reactive species and/or a decrease in antioxidant defenses. The search for new chemical entities with antioxidant profile is still thus an emerging field on ongoing interest. Due to the lack of reviews concerning the antioxidant activity of lichen-derived natural compounds, we performed a review of the antioxidant potential and mechanisms of action of natural compounds isolated from lichens. The search terms “lichens”, “antioxidants” and “antioxidant response elements” were used to retrieve articles in LILACS, PubMed and Web of Science published until February 2014. From a total of 319 articles surveyed, 32 met the established inclusion and exclusion criteria. It was observed that the most common isolated compound studied was usnic acid, cited in 14 out of the 32 articles. The most often described antioxidant assays for the study of in vitro antioxidant activity were mainly DPPH, LPO and SOD. The most suggested mechanisms of action were scavenging of reactive species, enzymatic activation and inhibition of iNOS. Thus, compounds isolated from lichens are possible candidates for the management of oxidative stress, and may be useful in the treatment of chronic diseases. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2017-10-07T05:46:05Z |
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Estrangeiro info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/169292 |
dc.identifier.issn.pt_BR.fl_str_mv |
1420-3049 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001048201 |
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1420-3049 001048201 |
url |
http://hdl.handle.net/10183/169292 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Molecules. Basel, Switzerland. Vol. 19, no. 9 (2014), p. 14496-14527 |
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openAccess |
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