Effects of childhood trauma on BDNF and TBARS during crack-cocaine withdrawal

• Autor(a) principal: Sordi, Anne Orgler
• Data de Publicação: 2020
• Outros Autores: Diemen, Lisia von, Schuch, Silvia Bassani, Ornell, Felipe, Kapczinski, Flávio Pereira, Pfaffenseller, Bianca, Gubert, Carolina de Moura, Aguiar, Bianca Wollenhaupt de, Salum Junior, Giovanni Abrahão, Pechansky, Flavio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/215188
• topic: Estresse oxidativo; Cocaína; Trauma psicológico; Experiências adversas da infância; Transtornos relacionados ao uso de substâncias; Fator neurotrófico derivado do encéfalo; Childhood trauma; Cocaine; Drug abuse; BDNF; Oxidative stress

Objective: To evaluate the association between childhood trauma (CT) and serum levels of brainderived neurotrophic factor (BDNF) and thiobarbituric acid-reactive substances (TBARS) during crackcocaine withdrawal. Method: Thirty-three male crack-cocaine users were recruited at admission to a public addiction treatment unit. Serum BDNF and TBARS levels were evaluated at intake and discharge. Information about drug use was assessed by the Addiction Severity Index-6th Version (ASI-6); CT was reported throughout the Childhood Trauma Questionnaire (CTQ). CTQ scores were calculated based on a latent analysis model that divided the sample into low-, medium-, and high-level trauma groups. Results: There was a significant increase in BDNF levels from admission to discharge, which did not differ across CT subgroups. For TBARS levels, we found a significant time vs. trauma interaction (F2,28 = 6.357, p = 0.005,Zp 2 = 0.312). In participants with low trauma level, TBARS decreased, while in those with a high trauma level, TBARS increased during early withdrawal. Conclusion: TBARS levels showed opposite patterns of change in crack-cocaine withdrawal according to baseline CT. These results suggest that CT could be associated with more severe neurological impairment during withdrawal.