Diazepam and fluoxetine decrease the stress response in zebrafish

Detalhes bibliográficos
Autor(a) principal: Abreu, Murilo Sander de
Data de Publicação: 2014
Outros Autores: Koakoski, Gessi, Ferreira, Daiane, Oliveira, Thiago Acosta, Rosa, João Gabriel Santos, Gusso, Darlan, Giacomini, Ana Cristina Vendrametto Varrone, Piato, Angelo Luis Stapassoli, Barcellos, Leonardo Jose Gil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/224419
Resumo: The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.
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spelling Abreu, Murilo Sander deKoakoski, GessiFerreira, DaianeOliveira, Thiago AcostaRosa, João Gabriel SantosGusso, DarlanGiacomini, Ana Cristina Vendrametto VarronePiato, Angelo Luis StapassoliBarcellos, Leonardo Jose Gil2021-07-23T04:41:27Z20141932-6203http://hdl.handle.net/10183/224419000933259The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.application/pdfengPLoS ONE. San Francisco. Vol. 9, no. 7 (July 2014), e103232, 5 f.DiazepamFluoxetinaPeixe-zebraEstresseDiazepam and fluoxetine decrease the stress response in zebrafishEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000933259.pdf.txt000933259.pdf.txtExtracted Texttext/plain24712http://www.lume.ufrgs.br/bitstream/10183/224419/2/000933259.pdf.txtc750d197cfdee25faa4563cff59af218MD52ORIGINAL000933259.pdfTexto completo (inglês)application/pdf408368http://www.lume.ufrgs.br/bitstream/10183/224419/1/000933259.pdf5d6f4e3f6bf7b7e490ce40918ff3a54aMD5110183/2244192023-01-18 06:02:03.491463oai:www.lume.ufrgs.br:10183/224419Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-01-18T08:02:03Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Diazepam and fluoxetine decrease the stress response in zebrafish
title Diazepam and fluoxetine decrease the stress response in zebrafish
spellingShingle Diazepam and fluoxetine decrease the stress response in zebrafish
Abreu, Murilo Sander de
Diazepam
Fluoxetina
Peixe-zebra
Estresse
title_short Diazepam and fluoxetine decrease the stress response in zebrafish
title_full Diazepam and fluoxetine decrease the stress response in zebrafish
title_fullStr Diazepam and fluoxetine decrease the stress response in zebrafish
title_full_unstemmed Diazepam and fluoxetine decrease the stress response in zebrafish
title_sort Diazepam and fluoxetine decrease the stress response in zebrafish
author Abreu, Murilo Sander de
author_facet Abreu, Murilo Sander de
Koakoski, Gessi
Ferreira, Daiane
Oliveira, Thiago Acosta
Rosa, João Gabriel Santos
Gusso, Darlan
Giacomini, Ana Cristina Vendrametto Varrone
Piato, Angelo Luis Stapassoli
Barcellos, Leonardo Jose Gil
author_role author
author2 Koakoski, Gessi
Ferreira, Daiane
Oliveira, Thiago Acosta
Rosa, João Gabriel Santos
Gusso, Darlan
Giacomini, Ana Cristina Vendrametto Varrone
Piato, Angelo Luis Stapassoli
Barcellos, Leonardo Jose Gil
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Abreu, Murilo Sander de
Koakoski, Gessi
Ferreira, Daiane
Oliveira, Thiago Acosta
Rosa, João Gabriel Santos
Gusso, Darlan
Giacomini, Ana Cristina Vendrametto Varrone
Piato, Angelo Luis Stapassoli
Barcellos, Leonardo Jose Gil
dc.subject.por.fl_str_mv Diazepam
Fluoxetina
Peixe-zebra
Estresse
topic Diazepam
Fluoxetina
Peixe-zebra
Estresse
description The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermediate concentrations of diazepam suppressed the stress response as measured by cortisol levels, whereas fluoxetine inhibited cortisol increase at concentrations similar to those found in the environment. These data suggest that the presence of psychoactive drugs in aquatic ecosystems could cause neuroendocrine dysfunction in fish.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2021-07-23T04:41:27Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/224419
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.nrb.pt_BR.fl_str_mv 000933259
identifier_str_mv 1932-6203
000933259
url http://hdl.handle.net/10183/224419
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv PLoS ONE. San Francisco. Vol. 9, no. 7 (July 2014), e103232, 5 f.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/224419/2/000933259.pdf.txt
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