Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/267272 |
Resumo: | Objectives: Movement behaviors and abdominal obesity are associated with higher inflammatory biomarkers. However, the role of waist circumference as a mediating factor is still unknown. Thus, our aims were to (1) test the associations between 24-hour movement behavior variables (physical activity, sedentary behavior, and sleep), abdominal obesity, and pro- and anti-inflammatory biomarkers; and (2) investigate whether abdominal obesity had a mediating effect between the investigated associations. Methods: This multicenter cross-sectional study included 3591 adolescents (aged 12-17 y) from 4 Brazilian cities. Waist circumference (in centimeters; at half the distance between the iliac crest and at the lower costal margin), 24-hour movement behaviors (validated questionnaire), high-sensitive C-reactive protein, and adiponectin (serum plasma) were evaluated. We used multiple mediation regression models (95% confidence interval) to determine if waist circumference mediated the association between 24-hour movement behaviors and pro- and anti-inflammatory biomarkers. Results: The results revealed that screen time and moderate to vigorous physical activity were not associated with pro- or anti-inflammatory biomarkers. However, sleep duration (in hours per day) was negatively associated with pro- (C-reactive protein, β = -0.08; 95% confidence interval, -0.38 to -0.02) and anti- (adiponectin, β = -0.31; 95% confidence interval, -2.13 to -0.12) inflammatory biomarkers. Our results also showed that waist circumference mediated the association between sleep duration and high-sensitive C-reactive protein (2.7%), and adiponectin (2.8%). Conclusion: Sleep duration was inversely associated with pro- and anti-inflammatory biomarkers, and these relations were mediated by abdominal obesity. Therefore, adolescents having healthy sleep can have implications for reducing waist circumference and inflammatory indicators. |
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Moraes, Augusto César Ferreira deOliveira, Vanessa Cassia MedeirosBurford, KatieSchaan, Beatriz D'AgordBloch, Katia VergettiCarvalho, Kenia Mara Baiocchi deCureau, Felipe VogtFerreira, Marcus Vinicius Nascimento2023-11-18T03:26:37Z20221543-5474http://hdl.handle.net/10183/267272001186544Objectives: Movement behaviors and abdominal obesity are associated with higher inflammatory biomarkers. However, the role of waist circumference as a mediating factor is still unknown. Thus, our aims were to (1) test the associations between 24-hour movement behavior variables (physical activity, sedentary behavior, and sleep), abdominal obesity, and pro- and anti-inflammatory biomarkers; and (2) investigate whether abdominal obesity had a mediating effect between the investigated associations. Methods: This multicenter cross-sectional study included 3591 adolescents (aged 12-17 y) from 4 Brazilian cities. Waist circumference (in centimeters; at half the distance between the iliac crest and at the lower costal margin), 24-hour movement behaviors (validated questionnaire), high-sensitive C-reactive protein, and adiponectin (serum plasma) were evaluated. We used multiple mediation regression models (95% confidence interval) to determine if waist circumference mediated the association between 24-hour movement behaviors and pro- and anti-inflammatory biomarkers. Results: The results revealed that screen time and moderate to vigorous physical activity were not associated with pro- or anti-inflammatory biomarkers. However, sleep duration (in hours per day) was negatively associated with pro- (C-reactive protein, β = -0.08; 95% confidence interval, -0.38 to -0.02) and anti- (adiponectin, β = -0.31; 95% confidence interval, -2.13 to -0.12) inflammatory biomarkers. Our results also showed that waist circumference mediated the association between sleep duration and high-sensitive C-reactive protein (2.7%), and adiponectin (2.8%). Conclusion: Sleep duration was inversely associated with pro- and anti-inflammatory biomarkers, and these relations were mediated by abdominal obesity. Therefore, adolescents having healthy sleep can have implications for reducing waist circumference and inflammatory indicators.application/pdfengJournal of Physical Activity and Health. Champaign, IL. Vol. 20, no. 10 (2023), p. 926-933AdiponectinaBiomarcadoresÍndice de massa corporalProteina C-reativaEstudos transversaisExercício físicoObesidade abdominalCircunferência da cinturaInflammatoryLife stylesWaist circumferenceAssociation between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescentsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001186544.pdf.txt001186544.pdf.txtExtracted Texttext/plain39053http://www.lume.ufrgs.br/bitstream/10183/267272/2/001186544.pdf.txt2fcc6b97820af20896f2521bf52f8dd0MD52ORIGINAL001186544.pdfTexto completo (inglês)application/pdf574014http://www.lume.ufrgs.br/bitstream/10183/267272/1/001186544.pdfcaec2c55d74877b842ef9268c0db54acMD5110183/2672722023-11-29 04:26:40.614924oai:www.lume.ufrgs.br:10183/267272Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-29T06:26:40Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents |
title |
Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents |
spellingShingle |
Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents Moraes, Augusto César Ferreira de Adiponectina Biomarcadores Índice de massa corporal Proteina C-reativa Estudos transversais Exercício físico Obesidade abdominal Circunferência da cintura Inflammatory Life styles Waist circumference |
title_short |
Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents |
title_full |
Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents |
title_fullStr |
Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents |
title_full_unstemmed |
Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents |
title_sort |
Association between sleep time and pro- and anti-inflammatory biomarkers is mediated by abdominal obesity among adolescents |
author |
Moraes, Augusto César Ferreira de |
author_facet |
Moraes, Augusto César Ferreira de Oliveira, Vanessa Cassia Medeiros Burford, Katie Schaan, Beatriz D'Agord Bloch, Katia Vergetti Carvalho, Kenia Mara Baiocchi de Cureau, Felipe Vogt Ferreira, Marcus Vinicius Nascimento |
author_role |
author |
author2 |
Oliveira, Vanessa Cassia Medeiros Burford, Katie Schaan, Beatriz D'Agord Bloch, Katia Vergetti Carvalho, Kenia Mara Baiocchi de Cureau, Felipe Vogt Ferreira, Marcus Vinicius Nascimento |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Moraes, Augusto César Ferreira de Oliveira, Vanessa Cassia Medeiros Burford, Katie Schaan, Beatriz D'Agord Bloch, Katia Vergetti Carvalho, Kenia Mara Baiocchi de Cureau, Felipe Vogt Ferreira, Marcus Vinicius Nascimento |
dc.subject.por.fl_str_mv |
Adiponectina Biomarcadores Índice de massa corporal Proteina C-reativa Estudos transversais Exercício físico Obesidade abdominal Circunferência da cintura |
topic |
Adiponectina Biomarcadores Índice de massa corporal Proteina C-reativa Estudos transversais Exercício físico Obesidade abdominal Circunferência da cintura Inflammatory Life styles Waist circumference |
dc.subject.eng.fl_str_mv |
Inflammatory Life styles Waist circumference |
description |
Objectives: Movement behaviors and abdominal obesity are associated with higher inflammatory biomarkers. However, the role of waist circumference as a mediating factor is still unknown. Thus, our aims were to (1) test the associations between 24-hour movement behavior variables (physical activity, sedentary behavior, and sleep), abdominal obesity, and pro- and anti-inflammatory biomarkers; and (2) investigate whether abdominal obesity had a mediating effect between the investigated associations. Methods: This multicenter cross-sectional study included 3591 adolescents (aged 12-17 y) from 4 Brazilian cities. Waist circumference (in centimeters; at half the distance between the iliac crest and at the lower costal margin), 24-hour movement behaviors (validated questionnaire), high-sensitive C-reactive protein, and adiponectin (serum plasma) were evaluated. We used multiple mediation regression models (95% confidence interval) to determine if waist circumference mediated the association between 24-hour movement behaviors and pro- and anti-inflammatory biomarkers. Results: The results revealed that screen time and moderate to vigorous physical activity were not associated with pro- or anti-inflammatory biomarkers. However, sleep duration (in hours per day) was negatively associated with pro- (C-reactive protein, β = -0.08; 95% confidence interval, -0.38 to -0.02) and anti- (adiponectin, β = -0.31; 95% confidence interval, -2.13 to -0.12) inflammatory biomarkers. Our results also showed that waist circumference mediated the association between sleep duration and high-sensitive C-reactive protein (2.7%), and adiponectin (2.8%). Conclusion: Sleep duration was inversely associated with pro- and anti-inflammatory biomarkers, and these relations were mediated by abdominal obesity. Therefore, adolescents having healthy sleep can have implications for reducing waist circumference and inflammatory indicators. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-11-18T03:26:37Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/267272 |
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1543-5474 |
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001186544 |
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http://hdl.handle.net/10183/267272 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of Physical Activity and Health. Champaign, IL. Vol. 20, no. 10 (2023), p. 926-933 |
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info:eu-repo/semantics/openAccess |
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