pH effect on stability and kinetics degradation of nitazoxanide in solution

Detalhes bibliográficos
Autor(a) principal: Barbosa, Fábio de Souza
Data de Publicação: 2020
Outros Autores: Pezzi, Leonardo Capra, Sorrentino, Julia Medeiros, Steppe, Martin, Volpato, Nadia Maria, Mendez, Andreas Sebastian Loureiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/216730
Resumo: Stability studies correspond to a set of tests designed to assess changes in the quality of a given drug over time and under the influence of a number of factors. Among these factors, pH plays an important role, due to the catalytic effect that hydronium and hydroxide ions can play in several reactions. In the present study, the degradation kinetics of nitazoxanide was evaluated over a wide pH range, and the main degradation product generated was identified by LC-MS/MS. Nitazoxanide showed first-order degradation kinetics in the pH range of 0.01 to 10.0 showing greater stability between pH 1.0 and 4.0. The degradation rate constant calculated for these pH was 0.0885 x 10-2 min-1 and 0.0689 x 10-2 min-1, respectively. The highest degradation rate constant value was observed at pH 10.0 (0.7418 x 10-2 min-1) followed by pH 0.01 (0.5882 x 10-2 min-1). A major degradation product (DP-1) was observed in all conditions tested. Through LC-MS/MS analysis, DP-1 was identified as a product of nitazoxanide deacetylation. The effect of pH on the stability of nitazoxanide and the kinetic data obtained contribute to a better understanding of the intrinsic stability characteristics of nitazoxanide.
id UFRGS-2_5abc019129a62e666a73bf276ab25bf0
oai_identifier_str oai:www.lume.ufrgs.br:10183/216730
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Barbosa, Fábio de SouzaPezzi, Leonardo CapraSorrentino, Julia MedeirosSteppe, MartinVolpato, Nadia MariaMendez, Andreas Sebastian Loureiro2020-12-19T04:19:25Z20202527-2616http://hdl.handle.net/10183/216730001119864Stability studies correspond to a set of tests designed to assess changes in the quality of a given drug over time and under the influence of a number of factors. Among these factors, pH plays an important role, due to the catalytic effect that hydronium and hydroxide ions can play in several reactions. In the present study, the degradation kinetics of nitazoxanide was evaluated over a wide pH range, and the main degradation product generated was identified by LC-MS/MS. Nitazoxanide showed first-order degradation kinetics in the pH range of 0.01 to 10.0 showing greater stability between pH 1.0 and 4.0. The degradation rate constant calculated for these pH was 0.0885 x 10-2 min-1 and 0.0689 x 10-2 min-1, respectively. The highest degradation rate constant value was observed at pH 10.0 (0.7418 x 10-2 min-1) followed by pH 0.01 (0.5882 x 10-2 min-1). A major degradation product (DP-1) was observed in all conditions tested. Through LC-MS/MS analysis, DP-1 was identified as a product of nitazoxanide deacetylation. The effect of pH on the stability of nitazoxanide and the kinetic data obtained contribute to a better understanding of the intrinsic stability characteristics of nitazoxanide.application/pdfengDrug analytical research. Porto Alegre (RS). Vol. 4, n. 1 (2020), p. 12-17FarmáciaEstabilidade de medicamentosNitazoxanideSabilityKineticDegradation productspH effect on stability and kinetics degradation of nitazoxanide in solutioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001119864.pdf.txt001119864.pdf.txtExtracted Texttext/plain20563http://www.lume.ufrgs.br/bitstream/10183/216730/2/001119864.pdf.txtdf22e7852d5996fded19ea8180ce8727MD52ORIGINAL001119864.pdfTexto completo (inglês)application/pdf290741http://www.lume.ufrgs.br/bitstream/10183/216730/1/001119864.pdfc28c6c575038e16f6a84e2cf4e958673MD5110183/2167302020-12-20 05:07:11.401263oai:www.lume.ufrgs.br:10183/216730Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-12-20T07:07:11Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv pH effect on stability and kinetics degradation of nitazoxanide in solution
title pH effect on stability and kinetics degradation of nitazoxanide in solution
spellingShingle pH effect on stability and kinetics degradation of nitazoxanide in solution
Barbosa, Fábio de Souza
Farmácia
Estabilidade de medicamentos
Nitazoxanide
Sability
Kinetic
Degradation products
title_short pH effect on stability and kinetics degradation of nitazoxanide in solution
title_full pH effect on stability and kinetics degradation of nitazoxanide in solution
title_fullStr pH effect on stability and kinetics degradation of nitazoxanide in solution
title_full_unstemmed pH effect on stability and kinetics degradation of nitazoxanide in solution
title_sort pH effect on stability and kinetics degradation of nitazoxanide in solution
author Barbosa, Fábio de Souza
author_facet Barbosa, Fábio de Souza
Pezzi, Leonardo Capra
Sorrentino, Julia Medeiros
Steppe, Martin
Volpato, Nadia Maria
Mendez, Andreas Sebastian Loureiro
author_role author
author2 Pezzi, Leonardo Capra
Sorrentino, Julia Medeiros
Steppe, Martin
Volpato, Nadia Maria
Mendez, Andreas Sebastian Loureiro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Fábio de Souza
Pezzi, Leonardo Capra
Sorrentino, Julia Medeiros
Steppe, Martin
Volpato, Nadia Maria
Mendez, Andreas Sebastian Loureiro
dc.subject.por.fl_str_mv Farmácia
Estabilidade de medicamentos
topic Farmácia
Estabilidade de medicamentos
Nitazoxanide
Sability
Kinetic
Degradation products
dc.subject.eng.fl_str_mv Nitazoxanide
Sability
Kinetic
Degradation products
description Stability studies correspond to a set of tests designed to assess changes in the quality of a given drug over time and under the influence of a number of factors. Among these factors, pH plays an important role, due to the catalytic effect that hydronium and hydroxide ions can play in several reactions. In the present study, the degradation kinetics of nitazoxanide was evaluated over a wide pH range, and the main degradation product generated was identified by LC-MS/MS. Nitazoxanide showed first-order degradation kinetics in the pH range of 0.01 to 10.0 showing greater stability between pH 1.0 and 4.0. The degradation rate constant calculated for these pH was 0.0885 x 10-2 min-1 and 0.0689 x 10-2 min-1, respectively. The highest degradation rate constant value was observed at pH 10.0 (0.7418 x 10-2 min-1) followed by pH 0.01 (0.5882 x 10-2 min-1). A major degradation product (DP-1) was observed in all conditions tested. Through LC-MS/MS analysis, DP-1 was identified as a product of nitazoxanide deacetylation. The effect of pH on the stability of nitazoxanide and the kinetic data obtained contribute to a better understanding of the intrinsic stability characteristics of nitazoxanide.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-12-19T04:19:25Z
dc.date.issued.fl_str_mv 2020
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/other
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/216730
dc.identifier.issn.pt_BR.fl_str_mv 2527-2616
dc.identifier.nrb.pt_BR.fl_str_mv 001119864
identifier_str_mv 2527-2616
001119864
url http://hdl.handle.net/10183/216730
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Drug analytical research. Porto Alegre (RS). Vol. 4, n. 1 (2020), p. 12-17
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/216730/2/001119864.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/216730/1/001119864.pdf
bitstream.checksum.fl_str_mv df22e7852d5996fded19ea8180ce8727
c28c6c575038e16f6a84e2cf4e958673
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1801225004943147008