Staging and neuroprogression in bipolar disorder : a systematic review of the literature

Detalhes bibliográficos
Autor(a) principal: Gama, Clarissa Severino
Data de Publicação: 2013
Outros Autores: Kunz, Maurício, Magalhães, Pedro Vieira da Silva, Kapczinski, Flávio Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/111609
Resumo: Introduction: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term “neuroprogression” has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. Method: A search in the PubMed database was performed with the following terms: “staging”, “neuroprogression”, “serum”, “plasma”, “blood”, “neuroimaging”, “PET scan”, “fMRI”, “neurotrophins”, “inflammatory markers” and “oxidative stress markers”, which were individually crossed with “cognition”, “functionality”, “response to treatments” and “bipolar disorder”. The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. Results: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. Conclusion: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies.
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spelling Gama, Clarissa SeverinoKunz, MaurícioMagalhães, Pedro Vieira da SilvaKapczinski, Flávio Pereira2015-03-04T01:57:57Z20131516-4446http://hdl.handle.net/10183/111609000945730Introduction: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term “neuroprogression” has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. Method: A search in the PubMed database was performed with the following terms: “staging”, “neuroprogression”, “serum”, “plasma”, “blood”, “neuroimaging”, “PET scan”, “fMRI”, “neurotrophins”, “inflammatory markers” and “oxidative stress markers”, which were individually crossed with “cognition”, “functionality”, “response to treatments” and “bipolar disorder”. The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. Results: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. Conclusion: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies.application/pdfengRevista brasileira de psiquiatria (1999). São Paulo. Vol. 35, n. 1 (mar. 2013), p. 70-74Transtorno bipolarProgressão da doençaNeuroimagemBipolar disorderClinical responseNeuroimagingNeuroprogressionSerum BiomarkersStagingStaging and neuroprogression in bipolar disorder : a systematic review of the literatureinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000945730.pdf000945730.pdfTexto completo (inglês)application/pdf350325http://www.lume.ufrgs.br/bitstream/10183/111609/1/000945730.pdf5af19e476c3ac17a73b45457e929c26bMD51TEXT000945730.pdf.txt000945730.pdf.txtExtracted Texttext/plain28529http://www.lume.ufrgs.br/bitstream/10183/111609/2/000945730.pdf.txt10c623f682a119e3553e8bf3a61842ffMD52THUMBNAIL000945730.pdf.jpg000945730.pdf.jpgGenerated Thumbnailimage/jpeg1883http://www.lume.ufrgs.br/bitstream/10183/111609/3/000945730.pdf.jpg05e008c7a760d633273b07fd497866f8MD5310183/1116092023-06-16 03:31:39.417137oai:www.lume.ufrgs.br:10183/111609Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-16T06:31:39Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Staging and neuroprogression in bipolar disorder : a systematic review of the literature
title Staging and neuroprogression in bipolar disorder : a systematic review of the literature
spellingShingle Staging and neuroprogression in bipolar disorder : a systematic review of the literature
Gama, Clarissa Severino
Transtorno bipolar
Progressão da doença
Neuroimagem
Bipolar disorder
Clinical response
Neuroimaging
Neuroprogression
Serum Biomarkers
Staging
title_short Staging and neuroprogression in bipolar disorder : a systematic review of the literature
title_full Staging and neuroprogression in bipolar disorder : a systematic review of the literature
title_fullStr Staging and neuroprogression in bipolar disorder : a systematic review of the literature
title_full_unstemmed Staging and neuroprogression in bipolar disorder : a systematic review of the literature
title_sort Staging and neuroprogression in bipolar disorder : a systematic review of the literature
author Gama, Clarissa Severino
author_facet Gama, Clarissa Severino
Kunz, Maurício
Magalhães, Pedro Vieira da Silva
Kapczinski, Flávio Pereira
author_role author
author2 Kunz, Maurício
Magalhães, Pedro Vieira da Silva
Kapczinski, Flávio Pereira
author2_role author
author
author
dc.contributor.author.fl_str_mv Gama, Clarissa Severino
Kunz, Maurício
Magalhães, Pedro Vieira da Silva
Kapczinski, Flávio Pereira
dc.subject.por.fl_str_mv Transtorno bipolar
Progressão da doença
Neuroimagem
topic Transtorno bipolar
Progressão da doença
Neuroimagem
Bipolar disorder
Clinical response
Neuroimaging
Neuroprogression
Serum Biomarkers
Staging
dc.subject.eng.fl_str_mv Bipolar disorder
Clinical response
Neuroimaging
Neuroprogression
Serum Biomarkers
Staging
description Introduction: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term “neuroprogression” has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. Method: A search in the PubMed database was performed with the following terms: “staging”, “neuroprogression”, “serum”, “plasma”, “blood”, “neuroimaging”, “PET scan”, “fMRI”, “neurotrophins”, “inflammatory markers” and “oxidative stress markers”, which were individually crossed with “cognition”, “functionality”, “response to treatments” and “bipolar disorder”. The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. Results: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. Conclusion: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies.
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dc.relation.ispartof.pt_BR.fl_str_mv Revista brasileira de psiquiatria (1999). São Paulo. Vol. 35, n. 1 (mar. 2013), p. 70-74
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