Staging and neuroprogression in bipolar disorder : a systematic review of the literature
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/111609 |
Resumo: | Introduction: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term “neuroprogression” has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. Method: A search in the PubMed database was performed with the following terms: “staging”, “neuroprogression”, “serum”, “plasma”, “blood”, “neuroimaging”, “PET scan”, “fMRI”, “neurotrophins”, “inflammatory markers” and “oxidative stress markers”, which were individually crossed with “cognition”, “functionality”, “response to treatments” and “bipolar disorder”. The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. Results: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. Conclusion: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies. |
id |
UFRGS-2_5afef7e6016a6aa0d4346868ab533ec3 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/111609 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Gama, Clarissa SeverinoKunz, MaurícioMagalhães, Pedro Vieira da SilvaKapczinski, Flávio Pereira2015-03-04T01:57:57Z20131516-4446http://hdl.handle.net/10183/111609000945730Introduction: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term “neuroprogression” has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. Method: A search in the PubMed database was performed with the following terms: “staging”, “neuroprogression”, “serum”, “plasma”, “blood”, “neuroimaging”, “PET scan”, “fMRI”, “neurotrophins”, “inflammatory markers” and “oxidative stress markers”, which were individually crossed with “cognition”, “functionality”, “response to treatments” and “bipolar disorder”. The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. Results: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. Conclusion: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies.application/pdfengRevista brasileira de psiquiatria (1999). São Paulo. Vol. 35, n. 1 (mar. 2013), p. 70-74Transtorno bipolarProgressão da doençaNeuroimagemBipolar disorderClinical responseNeuroimagingNeuroprogressionSerum BiomarkersStagingStaging and neuroprogression in bipolar disorder : a systematic review of the literatureinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000945730.pdf000945730.pdfTexto completo (inglês)application/pdf350325http://www.lume.ufrgs.br/bitstream/10183/111609/1/000945730.pdf5af19e476c3ac17a73b45457e929c26bMD51TEXT000945730.pdf.txt000945730.pdf.txtExtracted Texttext/plain28529http://www.lume.ufrgs.br/bitstream/10183/111609/2/000945730.pdf.txt10c623f682a119e3553e8bf3a61842ffMD52THUMBNAIL000945730.pdf.jpg000945730.pdf.jpgGenerated Thumbnailimage/jpeg1883http://www.lume.ufrgs.br/bitstream/10183/111609/3/000945730.pdf.jpg05e008c7a760d633273b07fd497866f8MD5310183/1116092023-06-16 03:31:39.417137oai:www.lume.ufrgs.br:10183/111609Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-16T06:31:39Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Staging and neuroprogression in bipolar disorder : a systematic review of the literature |
title |
Staging and neuroprogression in bipolar disorder : a systematic review of the literature |
spellingShingle |
Staging and neuroprogression in bipolar disorder : a systematic review of the literature Gama, Clarissa Severino Transtorno bipolar Progressão da doença Neuroimagem Bipolar disorder Clinical response Neuroimaging Neuroprogression Serum Biomarkers Staging |
title_short |
Staging and neuroprogression in bipolar disorder : a systematic review of the literature |
title_full |
Staging and neuroprogression in bipolar disorder : a systematic review of the literature |
title_fullStr |
Staging and neuroprogression in bipolar disorder : a systematic review of the literature |
title_full_unstemmed |
Staging and neuroprogression in bipolar disorder : a systematic review of the literature |
title_sort |
Staging and neuroprogression in bipolar disorder : a systematic review of the literature |
author |
Gama, Clarissa Severino |
author_facet |
Gama, Clarissa Severino Kunz, Maurício Magalhães, Pedro Vieira da Silva Kapczinski, Flávio Pereira |
author_role |
author |
author2 |
Kunz, Maurício Magalhães, Pedro Vieira da Silva Kapczinski, Flávio Pereira |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gama, Clarissa Severino Kunz, Maurício Magalhães, Pedro Vieira da Silva Kapczinski, Flávio Pereira |
dc.subject.por.fl_str_mv |
Transtorno bipolar Progressão da doença Neuroimagem |
topic |
Transtorno bipolar Progressão da doença Neuroimagem Bipolar disorder Clinical response Neuroimaging Neuroprogression Serum Biomarkers Staging |
dc.subject.eng.fl_str_mv |
Bipolar disorder Clinical response Neuroimaging Neuroprogression Serum Biomarkers Staging |
description |
Introduction: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term “neuroprogression” has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. Method: A search in the PubMed database was performed with the following terms: “staging”, “neuroprogression”, “serum”, “plasma”, “blood”, “neuroimaging”, “PET scan”, “fMRI”, “neurotrophins”, “inflammatory markers” and “oxidative stress markers”, which were individually crossed with “cognition”, “functionality”, “response to treatments” and “bipolar disorder”. The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. Results: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. Conclusion: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2015-03-04T01:57:57Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/111609 |
dc.identifier.issn.pt_BR.fl_str_mv |
1516-4446 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000945730 |
identifier_str_mv |
1516-4446 000945730 |
url |
http://hdl.handle.net/10183/111609 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista brasileira de psiquiatria (1999). São Paulo. Vol. 35, n. 1 (mar. 2013), p. 70-74 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/111609/1/000945730.pdf http://www.lume.ufrgs.br/bitstream/10183/111609/2/000945730.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/111609/3/000945730.pdf.jpg |
bitstream.checksum.fl_str_mv |
5af19e476c3ac17a73b45457e929c26b 10c623f682a119e3553e8bf3a61842ff 05e008c7a760d633273b07fd497866f8 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224866206056448 |