A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder

Detalhes bibliográficos
Autor(a) principal: Roman, Tatiana
Data de Publicação: 2009
Outros Autores: Rohde, Luis Augusto Paim, Hutz, Mara Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/109891
Resumo: Attention-deficit/hyperactivity disorder (ADHD) has a moderate to high genetic component, probably due to many genes with small effects. Several susceptibility genes have been suggested on the basis of hypotheses that catecholaminergic pathways in the brain are responsible for ADHD. However, many negative association findings have been reported, indicating a limited success for investigations using this approach. The results from genome-wide association studies have suggested that genes related to general brain functions rather than specific aspects of the disorder may contribute to its development. Plausible biological hypotheses linked to neurotransmission and neurodevelopment in general and common to different psychiatric conditions need to be considered when defining candidate genes for ADHD association studies.
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spelling Roman, TatianaRohde, Luis Augusto PaimHutz, Mara Helena2015-02-10T02:17:27Z20091756-994Xhttp://hdl.handle.net/10183/109891000730570Attention-deficit/hyperactivity disorder (ADHD) has a moderate to high genetic component, probably due to many genes with small effects. Several susceptibility genes have been suggested on the basis of hypotheses that catecholaminergic pathways in the brain are responsible for ADHD. However, many negative association findings have been reported, indicating a limited success for investigations using this approach. The results from genome-wide association studies have suggested that genes related to general brain functions rather than specific aspects of the disorder may contribute to its development. Plausible biological hypotheses linked to neurotransmission and neurodevelopment in general and common to different psychiatric conditions need to be considered when defining candidate genes for ADHD association studies.application/pdfengGenome medicine. United Kingdom. Vol. 1 (Nov. 2009), p. 107.1-107.3Transtorno do déficit de atenção com hiperatividadeInibidores da angiogêneseTransmissão sinápticaA role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorderEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000730570.pdf000730570.pdfTexto completo (inglês)application/pdf211142http://www.lume.ufrgs.br/bitstream/10183/109891/1/000730570.pdf0c75902038296f3846baa1f82d9c0c2fMD51TEXT000730570.pdf.txt000730570.pdf.txtExtracted Texttext/plain16555http://www.lume.ufrgs.br/bitstream/10183/109891/2/000730570.pdf.txt5b7ca2c3e6c3924702d5bec8663268e5MD52THUMBNAIL000730570.pdf.jpg000730570.pdf.jpgGenerated Thumbnailimage/jpeg2197http://www.lume.ufrgs.br/bitstream/10183/109891/3/000730570.pdf.jpg58c0b80b26fa19f7f67be8b08a6bce21MD5310183/1098912023-09-29 03:37:08.847962oai:www.lume.ufrgs.br:10183/109891Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-29T06:37:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
title A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
spellingShingle A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
Roman, Tatiana
Transtorno do déficit de atenção com hiperatividade
Inibidores da angiogênese
Transmissão sináptica
title_short A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
title_full A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
title_fullStr A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
title_full_unstemmed A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
title_sort A role for neurotransmission and neurodevelopment in attention-deficit/hyperactivity disorder
author Roman, Tatiana
author_facet Roman, Tatiana
Rohde, Luis Augusto Paim
Hutz, Mara Helena
author_role author
author2 Rohde, Luis Augusto Paim
Hutz, Mara Helena
author2_role author
author
dc.contributor.author.fl_str_mv Roman, Tatiana
Rohde, Luis Augusto Paim
Hutz, Mara Helena
dc.subject.por.fl_str_mv Transtorno do déficit de atenção com hiperatividade
Inibidores da angiogênese
Transmissão sináptica
topic Transtorno do déficit de atenção com hiperatividade
Inibidores da angiogênese
Transmissão sináptica
description Attention-deficit/hyperactivity disorder (ADHD) has a moderate to high genetic component, probably due to many genes with small effects. Several susceptibility genes have been suggested on the basis of hypotheses that catecholaminergic pathways in the brain are responsible for ADHD. However, many negative association findings have been reported, indicating a limited success for investigations using this approach. The results from genome-wide association studies have suggested that genes related to general brain functions rather than specific aspects of the disorder may contribute to its development. Plausible biological hypotheses linked to neurotransmission and neurodevelopment in general and common to different psychiatric conditions need to be considered when defining candidate genes for ADHD association studies.
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/109891
dc.identifier.issn.pt_BR.fl_str_mv 1756-994X
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dc.relation.ispartof.pt_BR.fl_str_mv Genome medicine. United Kingdom. Vol. 1 (Nov. 2009), p. 107.1-107.3
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