UV spectrophotometric method for quantitative determination of agomelatine in coated tablets

Detalhes bibliográficos
Autor(a) principal: Barbosa, Fábio de Souza
Data de Publicação: 2017
Outros Autores: Rodrigues, Vanise Coty, Volpato, Nadia Maria, Schapoval, Elfrides Eva Scherman, Steppe, Martin, Garcia, Cassia Virginia, Mendez, Andreas Sebastian Loureiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/177563
Resumo: UV spectrophotometry is an analytical technique used routinely for qualitative and quantitative assay due the low cost and reliability during analysis. In this work, it was validated a quantitative UV method for determination of agomelatine in coated tablets. The parameters specificity, linearity, precision, accuracy and robustness were evaluated according to official guidelines. Methanol was selected as solvent and the maximum wavelength for drug analysis was 230 nm. The purposed assay showed to be specific and the linearity was proved in a range of 0.5 - 2.5 μg/mL. The RSD values obtained during precision assay (inter-day RSD = 1.75%) indicated the method reproducibility, and the accuracy testing showed good results from recovery test. Robustness assay was complementary and showed that the purposed method is adequate for drug quantitation in commercial samples, being a reliable alternative to chromatographic assay.
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spelling Barbosa, Fábio de SouzaRodrigues, Vanise CotyVolpato, Nadia MariaSchapoval, Elfrides Eva SchermanSteppe, MartinGarcia, Cassia VirginiaMendez, Andreas Sebastian Loureiro2018-05-05T03:16:11Z20172527-2616http://hdl.handle.net/10183/177563001058385UV spectrophotometry is an analytical technique used routinely for qualitative and quantitative assay due the low cost and reliability during analysis. In this work, it was validated a quantitative UV method for determination of agomelatine in coated tablets. The parameters specificity, linearity, precision, accuracy and robustness were evaluated according to official guidelines. Methanol was selected as solvent and the maximum wavelength for drug analysis was 230 nm. The purposed assay showed to be specific and the linearity was proved in a range of 0.5 - 2.5 μg/mL. The RSD values obtained during precision assay (inter-day RSD = 1.75%) indicated the method reproducibility, and the accuracy testing showed good results from recovery test. Robustness assay was complementary and showed that the purposed method is adequate for drug quantitation in commercial samples, being a reliable alternative to chromatographic assay.application/pdfengDrug Analytical Research. Porto Alegre, RS. Vol. 1, no. 2 (2017), p. 24-29EspectrofotometriaAntidepressivosAgomelatineUV spectrophotometryValidationQuantitationUV spectrophotometric method for quantitative determination of agomelatine in coated tabletsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001058385.pdf001058385.pdfTexto completo (inglês)application/pdf157647http://www.lume.ufrgs.br/bitstream/10183/177563/1/001058385.pdf5f58deaac359918df9d5a5ab24bfef98MD51TEXT001058385.pdf.txt001058385.pdf.txtExtracted Texttext/plain17919http://www.lume.ufrgs.br/bitstream/10183/177563/2/001058385.pdf.txt564b80bcfcc46ead29c94989f6191443MD5210183/1775632018-05-06 02:26:37.775268oai:www.lume.ufrgs.br:10183/177563Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-05-06T05:26:37Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv UV spectrophotometric method for quantitative determination of agomelatine in coated tablets
title UV spectrophotometric method for quantitative determination of agomelatine in coated tablets
spellingShingle UV spectrophotometric method for quantitative determination of agomelatine in coated tablets
Barbosa, Fábio de Souza
Espectrofotometria
Antidepressivos
Agomelatine
UV spectrophotometry
Validation
Quantitation
title_short UV spectrophotometric method for quantitative determination of agomelatine in coated tablets
title_full UV spectrophotometric method for quantitative determination of agomelatine in coated tablets
title_fullStr UV spectrophotometric method for quantitative determination of agomelatine in coated tablets
title_full_unstemmed UV spectrophotometric method for quantitative determination of agomelatine in coated tablets
title_sort UV spectrophotometric method for quantitative determination of agomelatine in coated tablets
author Barbosa, Fábio de Souza
author_facet Barbosa, Fábio de Souza
Rodrigues, Vanise Coty
Volpato, Nadia Maria
Schapoval, Elfrides Eva Scherman
Steppe, Martin
Garcia, Cassia Virginia
Mendez, Andreas Sebastian Loureiro
author_role author
author2 Rodrigues, Vanise Coty
Volpato, Nadia Maria
Schapoval, Elfrides Eva Scherman
Steppe, Martin
Garcia, Cassia Virginia
Mendez, Andreas Sebastian Loureiro
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Fábio de Souza
Rodrigues, Vanise Coty
Volpato, Nadia Maria
Schapoval, Elfrides Eva Scherman
Steppe, Martin
Garcia, Cassia Virginia
Mendez, Andreas Sebastian Loureiro
dc.subject.por.fl_str_mv Espectrofotometria
Antidepressivos
topic Espectrofotometria
Antidepressivos
Agomelatine
UV spectrophotometry
Validation
Quantitation
dc.subject.eng.fl_str_mv Agomelatine
UV spectrophotometry
Validation
Quantitation
description UV spectrophotometry is an analytical technique used routinely for qualitative and quantitative assay due the low cost and reliability during analysis. In this work, it was validated a quantitative UV method for determination of agomelatine in coated tablets. The parameters specificity, linearity, precision, accuracy and robustness were evaluated according to official guidelines. Methanol was selected as solvent and the maximum wavelength for drug analysis was 230 nm. The purposed assay showed to be specific and the linearity was proved in a range of 0.5 - 2.5 μg/mL. The RSD values obtained during precision assay (inter-day RSD = 1.75%) indicated the method reproducibility, and the accuracy testing showed good results from recovery test. Robustness assay was complementary and showed that the purposed method is adequate for drug quantitation in commercial samples, being a reliable alternative to chromatographic assay.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-05-05T03:16:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/other
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/177563
dc.identifier.issn.pt_BR.fl_str_mv 2527-2616
dc.identifier.nrb.pt_BR.fl_str_mv 001058385
identifier_str_mv 2527-2616
001058385
url http://hdl.handle.net/10183/177563
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Drug Analytical Research. Porto Alegre, RS. Vol. 1, no. 2 (2017), p. 24-29
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
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instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
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institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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