Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)

Detalhes bibliográficos
Autor(a) principal: Kianoush, Sina
Data de Publicação: 2017
Outros Autores: Yakoob, Mohammad Yawar, Al-Rifai, Mahmoud, DeFilippis, Andrew Paul, Bittencourt, Márcio Sommer, Duncan, Bruce Bartholow, Benseñor, Isabela Judith Martins, Bhatnagar, Aruni, Lotufo, Paulo Andrade, Blaha, Michael Joseph
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/188927
Resumo: Background-—There is a need to identify sensitive biomarkers of early tobacco-related cardiovascular disease. We examined the association of smoking status, burden, time since quitting, and intensity, with markers of inflammation and subclinical atherosclerosis. Methods and Results-—We studied 14 103 participants without clinical cardiovascular disease in ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). We evaluated baseline cross-sectional associations between smoking parameters and inflammation (highsensitivity C-reactive protein [hsCRP]) and measures of subclinical atherosclerosis (carotid intima–media thickness, ankle-brachial index, and coronary artery calcium [CAC]). The cohort included 1844 current smokers, 4121 former smokers, and 8138 never smokers. Mean age was 51.7 8.9 years; 44.8% were male. After multivariable adjustment, compared with never smokers, current smokers had significantly higher levels of hsCRP (b=0.24, 0.19–0.29 mg/L; P<0.001) and carotid intima–media thickness (b=0.03, 0.02–0.04 mm; P<0.001) and odds of ankle-brachial index ≤1.0 (odds ratio: 2.52; 95% confidence interval, 2.06–3.08; P<0.001) and CAC >0 (odds ratio: 1.83; 95% confidence interval, 1.46–2.30; P<0.001). Among former and current smokers, pack-years of smoking (burden) were significantly associated with hsCRP (P<0.001 and P=0.006, respectively) and CAC (P<0.001 and P=0.002, respectively). Among former smokers, hsCRP and carotid intima–media thickness levels and odds of ankle-brachial index ≤1.0 and CAC >0 were lower with increasing time since quitting (P<0.01). Among current smokers, number of cigarettes per day (intensity) was positively associated with hsCRP (P<0.001) and CAC >0 (P=0.03) after adjusting for duration of smoking. Conclusions-—Strong associations were observed between smoking status, burden, and intensity with inflammation (hsCRP) and subclinical atherosclerosis (carotid intima–media thickness, ankle-brachial index, CAC). These markers of early cardiovascular disease injury may be used for the further study and regulation of traditional and novel tobacco products.
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spelling Kianoush, SinaYakoob, Mohammad YawarAl-Rifai, MahmoudDeFilippis, Andrew PaulBittencourt, Márcio SommerDuncan, Bruce BartholowBenseñor, Isabela Judith MartinsBhatnagar, AruniLotufo, Paulo AndradeBlaha, Michael Joseph2019-02-20T02:37:09Z20172047-9980http://hdl.handle.net/10183/188927001085186Background-—There is a need to identify sensitive biomarkers of early tobacco-related cardiovascular disease. We examined the association of smoking status, burden, time since quitting, and intensity, with markers of inflammation and subclinical atherosclerosis. Methods and Results-—We studied 14 103 participants without clinical cardiovascular disease in ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). We evaluated baseline cross-sectional associations between smoking parameters and inflammation (highsensitivity C-reactive protein [hsCRP]) and measures of subclinical atherosclerosis (carotid intima–media thickness, ankle-brachial index, and coronary artery calcium [CAC]). The cohort included 1844 current smokers, 4121 former smokers, and 8138 never smokers. Mean age was 51.7 8.9 years; 44.8% were male. After multivariable adjustment, compared with never smokers, current smokers had significantly higher levels of hsCRP (b=0.24, 0.19–0.29 mg/L; P<0.001) and carotid intima–media thickness (b=0.03, 0.02–0.04 mm; P<0.001) and odds of ankle-brachial index ≤1.0 (odds ratio: 2.52; 95% confidence interval, 2.06–3.08; P<0.001) and CAC >0 (odds ratio: 1.83; 95% confidence interval, 1.46–2.30; P<0.001). Among former and current smokers, pack-years of smoking (burden) were significantly associated with hsCRP (P<0.001 and P=0.006, respectively) and CAC (P<0.001 and P=0.002, respectively). Among former smokers, hsCRP and carotid intima–media thickness levels and odds of ankle-brachial index ≤1.0 and CAC >0 were lower with increasing time since quitting (P<0.01). Among current smokers, number of cigarettes per day (intensity) was positively associated with hsCRP (P<0.001) and CAC >0 (P=0.03) after adjusting for duration of smoking. Conclusions-—Strong associations were observed between smoking status, burden, and intensity with inflammation (hsCRP) and subclinical atherosclerosis (carotid intima–media thickness, ankle-brachial index, CAC). These markers of early cardiovascular disease injury may be used for the further study and regulation of traditional and novel tobacco products.application/pdfengJournal of the American Heart Association. Oxford. vol. 6, no. 6 (Nov. 2017), e005088, 27 f.AteroscleroseInflamaçãoTabagismoAtherosclerosisInflammationSmokingSubclinical atherosclerosis risk factorTobacco productsAssociations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001085186.pdf.txt001085186.pdf.txtExtracted Texttext/plain79014http://www.lume.ufrgs.br/bitstream/10183/188927/2/001085186.pdf.txt54205cc54146493d97300c7a7747035eMD52ORIGINAL001085186.pdfTexto completo (inglês)application/pdf958661http://www.lume.ufrgs.br/bitstream/10183/188927/1/001085186.pdf4012bdf54ae1d95911adff8a2c79c337MD5110183/1889272019-03-01 02:28:15.203596oai:www.lume.ufrgs.br:10183/188927Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-03-01T05:28:15Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)
title Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)
spellingShingle Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)
Kianoush, Sina
Aterosclerose
Inflamação
Tabagismo
Atherosclerosis
Inflammation
Smoking
Subclinical atherosclerosis risk factor
Tobacco products
title_short Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)
title_full Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)
title_fullStr Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)
title_full_unstemmed Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)
title_sort Associations of cigarette smoking with subclinical inflammation and atherosclerosis : ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health)
author Kianoush, Sina
author_facet Kianoush, Sina
Yakoob, Mohammad Yawar
Al-Rifai, Mahmoud
DeFilippis, Andrew Paul
Bittencourt, Márcio Sommer
Duncan, Bruce Bartholow
Benseñor, Isabela Judith Martins
Bhatnagar, Aruni
Lotufo, Paulo Andrade
Blaha, Michael Joseph
author_role author
author2 Yakoob, Mohammad Yawar
Al-Rifai, Mahmoud
DeFilippis, Andrew Paul
Bittencourt, Márcio Sommer
Duncan, Bruce Bartholow
Benseñor, Isabela Judith Martins
Bhatnagar, Aruni
Lotufo, Paulo Andrade
Blaha, Michael Joseph
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kianoush, Sina
Yakoob, Mohammad Yawar
Al-Rifai, Mahmoud
DeFilippis, Andrew Paul
Bittencourt, Márcio Sommer
Duncan, Bruce Bartholow
Benseñor, Isabela Judith Martins
Bhatnagar, Aruni
Lotufo, Paulo Andrade
Blaha, Michael Joseph
dc.subject.por.fl_str_mv Aterosclerose
Inflamação
Tabagismo
topic Aterosclerose
Inflamação
Tabagismo
Atherosclerosis
Inflammation
Smoking
Subclinical atherosclerosis risk factor
Tobacco products
dc.subject.eng.fl_str_mv Atherosclerosis
Inflammation
Smoking
Subclinical atherosclerosis risk factor
Tobacco products
description Background-—There is a need to identify sensitive biomarkers of early tobacco-related cardiovascular disease. We examined the association of smoking status, burden, time since quitting, and intensity, with markers of inflammation and subclinical atherosclerosis. Methods and Results-—We studied 14 103 participants without clinical cardiovascular disease in ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). We evaluated baseline cross-sectional associations between smoking parameters and inflammation (highsensitivity C-reactive protein [hsCRP]) and measures of subclinical atherosclerosis (carotid intima–media thickness, ankle-brachial index, and coronary artery calcium [CAC]). The cohort included 1844 current smokers, 4121 former smokers, and 8138 never smokers. Mean age was 51.7 8.9 years; 44.8% were male. After multivariable adjustment, compared with never smokers, current smokers had significantly higher levels of hsCRP (b=0.24, 0.19–0.29 mg/L; P<0.001) and carotid intima–media thickness (b=0.03, 0.02–0.04 mm; P<0.001) and odds of ankle-brachial index ≤1.0 (odds ratio: 2.52; 95% confidence interval, 2.06–3.08; P<0.001) and CAC >0 (odds ratio: 1.83; 95% confidence interval, 1.46–2.30; P<0.001). Among former and current smokers, pack-years of smoking (burden) were significantly associated with hsCRP (P<0.001 and P=0.006, respectively) and CAC (P<0.001 and P=0.002, respectively). Among former smokers, hsCRP and carotid intima–media thickness levels and odds of ankle-brachial index ≤1.0 and CAC >0 were lower with increasing time since quitting (P<0.01). Among current smokers, number of cigarettes per day (intensity) was positively associated with hsCRP (P<0.001) and CAC >0 (P=0.03) after adjusting for duration of smoking. Conclusions-—Strong associations were observed between smoking status, burden, and intensity with inflammation (hsCRP) and subclinical atherosclerosis (carotid intima–media thickness, ankle-brachial index, CAC). These markers of early cardiovascular disease injury may be used for the further study and regulation of traditional and novel tobacco products.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-02-20T02:37:09Z
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dc.relation.ispartof.pt_BR.fl_str_mv Journal of the American Heart Association. Oxford. vol. 6, no. 6 (Nov. 2017), e005088, 27 f.
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