Blood transfusion-related immunomodulation

Detalhes bibliográficos
Autor(a) principal: Vargas, Luciana do Nascimento
Data de Publicação: 2014
Outros Autores: Garcia, Lais Oliveira, Galvão, Ananda Cristine Santos, Onsten, Tor Gunnar Hugo, Coitinho, Adriana Simon, Sekine, Leo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/158440
Resumo: The phenomenon of transfusion-related immunomodulation (TRIM) has been studied since the observation of a higher kidney allograft survival in patients who had received a higher number of transfusions. Conversely, it has been suggested as one of the possible causes related to the development of infections in patients with multiple blood transfusions and/or after a major surgery, and has been also associated with a decreased function of natural killer cells (NK) and antigen-presenting cells (APCs), reduced cell-mediated immunity, and increased regulatory T cells (Tregs). This review aimed to conceptualize TRIM and discuss some aspects related to its mechanisms and the prevention of immunomodulatory events.
id UFRGS-2_7710c57ed3cbb4481150812cf96442cf
oai_identifier_str oai:www.lume.ufrgs.br:10183/158440
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Vargas, Luciana do NascimentoGarcia, Lais OliveiraGalvão, Ananda Cristine SantosOnsten, Tor Gunnar HugoCoitinho, Adriana SimonSekine, Leo2017-05-24T02:26:26Z20142357-9730http://hdl.handle.net/10183/158440000954948The phenomenon of transfusion-related immunomodulation (TRIM) has been studied since the observation of a higher kidney allograft survival in patients who had received a higher number of transfusions. Conversely, it has been suggested as one of the possible causes related to the development of infections in patients with multiple blood transfusions and/or after a major surgery, and has been also associated with a decreased function of natural killer cells (NK) and antigen-presenting cells (APCs), reduced cell-mediated immunity, and increased regulatory T cells (Tregs). This review aimed to conceptualize TRIM and discuss some aspects related to its mechanisms and the prevention of immunomodulatory events.application/pdfporClinical and biomedical research. Vol. 34, no. 4 (2014), p. 333-341ImunomodulacaoTransfusão de sangueImunossupressãoInfecçõesLeucócitosImmunomodulationBoold transfusionImmunisuppressionInfectionLeukocytesBlood transfusion-related immunomodulationImunomodulação relacionada à transfusão de hemocomponentes info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000954948.pdf000954948.pdfTexto completo (inglês)application/pdf1338397http://www.lume.ufrgs.br/bitstream/10183/158440/1/000954948.pdf4abaac4d857c72473888caa8347ea6b0MD51TEXT000954948.pdf.txt000954948.pdf.txtExtracted Texttext/plain39984http://www.lume.ufrgs.br/bitstream/10183/158440/2/000954948.pdf.txt8519a55fe295b4de60e8931a7278f0c2MD5210183/1584402023-07-01 03:41:24.889846oai:www.lume.ufrgs.br:10183/158440Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-07-01T06:41:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Blood transfusion-related immunomodulation
dc.title.alternative.pt.fl_str_mv Imunomodulação relacionada à transfusão de hemocomponentes
title Blood transfusion-related immunomodulation
spellingShingle Blood transfusion-related immunomodulation
Vargas, Luciana do Nascimento
Imunomodulacao
Transfusão de sangue
Imunossupressão
Infecções
Leucócitos
Immunomodulation
Boold transfusion
Immunisuppression
Infection
Leukocytes
title_short Blood transfusion-related immunomodulation
title_full Blood transfusion-related immunomodulation
title_fullStr Blood transfusion-related immunomodulation
title_full_unstemmed Blood transfusion-related immunomodulation
title_sort Blood transfusion-related immunomodulation
author Vargas, Luciana do Nascimento
author_facet Vargas, Luciana do Nascimento
Garcia, Lais Oliveira
Galvão, Ananda Cristine Santos
Onsten, Tor Gunnar Hugo
Coitinho, Adriana Simon
Sekine, Leo
author_role author
author2 Garcia, Lais Oliveira
Galvão, Ananda Cristine Santos
Onsten, Tor Gunnar Hugo
Coitinho, Adriana Simon
Sekine, Leo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vargas, Luciana do Nascimento
Garcia, Lais Oliveira
Galvão, Ananda Cristine Santos
Onsten, Tor Gunnar Hugo
Coitinho, Adriana Simon
Sekine, Leo
dc.subject.por.fl_str_mv Imunomodulacao
Transfusão de sangue
Imunossupressão
Infecções
Leucócitos
topic Imunomodulacao
Transfusão de sangue
Imunossupressão
Infecções
Leucócitos
Immunomodulation
Boold transfusion
Immunisuppression
Infection
Leukocytes
dc.subject.eng.fl_str_mv Immunomodulation
Boold transfusion
Immunisuppression
Infection
Leukocytes
description The phenomenon of transfusion-related immunomodulation (TRIM) has been studied since the observation of a higher kidney allograft survival in patients who had received a higher number of transfusions. Conversely, it has been suggested as one of the possible causes related to the development of infections in patients with multiple blood transfusions and/or after a major surgery, and has been also associated with a decreased function of natural killer cells (NK) and antigen-presenting cells (APCs), reduced cell-mediated immunity, and increased regulatory T cells (Tregs). This review aimed to conceptualize TRIM and discuss some aspects related to its mechanisms and the prevention of immunomodulatory events.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2017-05-24T02:26:26Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/other
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/158440
dc.identifier.issn.pt_BR.fl_str_mv 2357-9730
dc.identifier.nrb.pt_BR.fl_str_mv 000954948
identifier_str_mv 2357-9730
000954948
url http://hdl.handle.net/10183/158440
dc.language.iso.fl_str_mv por
language por
dc.relation.ispartof.pt_BR.fl_str_mv Clinical and biomedical research. Vol. 34, no. 4 (2014), p. 333-341
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/158440/1/000954948.pdf
http://www.lume.ufrgs.br/bitstream/10183/158440/2/000954948.pdf.txt
bitstream.checksum.fl_str_mv 4abaac4d857c72473888caa8347ea6b0
8519a55fe295b4de60e8931a7278f0c2
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1815447630676754432

Registros relacionados