ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure

Detalhes bibliográficos
Autor(a) principal: Paskulin, Diego D'Ávila
Data de Publicação: 2013
Outros Autores: Cunha Filho, João Sabino Lahorgue da, Paskulin, Lívia D'Avila, Souza, Carlos Augusto Bastos de, Prolla, Patrícia Ashton
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/194128
Resumo: Estrogen receptor alpha has a central role in human fertility by regulating estrogen action in all human reproductive tissues. Leukemia inhibitory factor (LIF) expression, a cytokine critical for blastocyst implantation, is mediated by estrogen signaling, so we hypothesized that ESR1 gene polymorphisms might be candidate risk markers for endometriosis-related infertility and in vitro fertilization (IVF) failure. We included 98 infertile women with endometriosis, 115 infertile women with at least one IVF failure and also 134 fertile women as controls. TaqMan SNP assays were used for genotyping LIF (rs929271), MDM2 (rs2279744), MDM4 (rs1563828), USP7 (rs1529916), and ESR1 (rs9340799 and rs2234693) polymorphisms.TheSNP ESR1 rs9340799 was associated with endometriosis-related infertility ( < 0.001) and also with IVF failure ( = 0.018). After controlling for age, infertile women with ESR1 rs9340799 GG genotype presented 4-fold increased risk of endometriosis (OR 4.67, 95% CI 1.84–11.83, = 0.001) and 3- fold increased risk of IVF failure (OR 3.33, 95% CI 1.38–8.03, = 0.007). Our results demonstrate an association between ESR1 rs9340799 polymorphism and infertile women with endometriosis and also with women who were submitted to IVF procedures and had no blastocyst implantation.
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spelling Paskulin, Diego D'ÁvilaCunha Filho, João Sabino Lahorgue daPaskulin, Lívia D'AvilaSouza, Carlos Augusto Bastos deProlla, Patrícia Ashton2019-05-11T02:37:27Z20130278-0240http://hdl.handle.net/10183/194128000977514Estrogen receptor alpha has a central role in human fertility by regulating estrogen action in all human reproductive tissues. Leukemia inhibitory factor (LIF) expression, a cytokine critical for blastocyst implantation, is mediated by estrogen signaling, so we hypothesized that ESR1 gene polymorphisms might be candidate risk markers for endometriosis-related infertility and in vitro fertilization (IVF) failure. We included 98 infertile women with endometriosis, 115 infertile women with at least one IVF failure and also 134 fertile women as controls. TaqMan SNP assays were used for genotyping LIF (rs929271), MDM2 (rs2279744), MDM4 (rs1563828), USP7 (rs1529916), and ESR1 (rs9340799 and rs2234693) polymorphisms.TheSNP ESR1 rs9340799 was associated with endometriosis-related infertility ( < 0.001) and also with IVF failure ( = 0.018). After controlling for age, infertile women with ESR1 rs9340799 GG genotype presented 4-fold increased risk of endometriosis (OR 4.67, 95% CI 1.84–11.83, = 0.001) and 3- fold increased risk of IVF failure (OR 3.33, 95% CI 1.38–8.03, = 0.007). Our results demonstrate an association between ESR1 rs9340799 polymorphism and infertile women with endometriosis and also with women who were submitted to IVF procedures and had no blastocyst implantation.application/pdfengDisease markers. Chichester. Vol. 35, no. 6 (2013), p. 907-913EndometrioseReceptores estrogenicosFertilização in vitroESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failureEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000977514.pdf.txt000977514.pdf.txtExtracted Texttext/plain32475http://www.lume.ufrgs.br/bitstream/10183/194128/2/000977514.pdf.txt1f3e3b30da72992662d18cb0727f74ddMD52ORIGINAL000977514.pdfTexto completo (inglês)application/pdf507037http://www.lume.ufrgs.br/bitstream/10183/194128/1/000977514.pdf696d832c7c8b2b7ba25bffc601b18e68MD5110183/1941282019-05-12 02:36:09.150458oai:www.lume.ufrgs.br:10183/194128Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-05-12T05:36:09Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure
title ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure
spellingShingle ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure
Paskulin, Diego D'Ávila
Endometriose
Receptores estrogenicos
Fertilização in vitro
title_short ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure
title_full ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure
title_fullStr ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure
title_full_unstemmed ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure
title_sort ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure
author Paskulin, Diego D'Ávila
author_facet Paskulin, Diego D'Ávila
Cunha Filho, João Sabino Lahorgue da
Paskulin, Lívia D'Avila
Souza, Carlos Augusto Bastos de
Prolla, Patrícia Ashton
author_role author
author2 Cunha Filho, João Sabino Lahorgue da
Paskulin, Lívia D'Avila
Souza, Carlos Augusto Bastos de
Prolla, Patrícia Ashton
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Paskulin, Diego D'Ávila
Cunha Filho, João Sabino Lahorgue da
Paskulin, Lívia D'Avila
Souza, Carlos Augusto Bastos de
Prolla, Patrícia Ashton
dc.subject.por.fl_str_mv Endometriose
Receptores estrogenicos
Fertilização in vitro
topic Endometriose
Receptores estrogenicos
Fertilização in vitro
description Estrogen receptor alpha has a central role in human fertility by regulating estrogen action in all human reproductive tissues. Leukemia inhibitory factor (LIF) expression, a cytokine critical for blastocyst implantation, is mediated by estrogen signaling, so we hypothesized that ESR1 gene polymorphisms might be candidate risk markers for endometriosis-related infertility and in vitro fertilization (IVF) failure. We included 98 infertile women with endometriosis, 115 infertile women with at least one IVF failure and also 134 fertile women as controls. TaqMan SNP assays were used for genotyping LIF (rs929271), MDM2 (rs2279744), MDM4 (rs1563828), USP7 (rs1529916), and ESR1 (rs9340799 and rs2234693) polymorphisms.TheSNP ESR1 rs9340799 was associated with endometriosis-related infertility ( < 0.001) and also with IVF failure ( = 0.018). After controlling for age, infertile women with ESR1 rs9340799 GG genotype presented 4-fold increased risk of endometriosis (OR 4.67, 95% CI 1.84–11.83, = 0.001) and 3- fold increased risk of IVF failure (OR 3.33, 95% CI 1.38–8.03, = 0.007). Our results demonstrate an association between ESR1 rs9340799 polymorphism and infertile women with endometriosis and also with women who were submitted to IVF procedures and had no blastocyst implantation.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2019-05-11T02:37:27Z
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dc.relation.ispartof.pt_BR.fl_str_mv Disease markers. Chichester. Vol. 35, no. 6 (2013), p. 907-913
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