Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/177561 |
Resumo: | Studies have suggested that total energy intake and diet composition affect lifespan and ageing. A high-fat diet induces oxidative stress and affects the development of diseases. In contrast, antioxidants are capable of reducing its harmful effects. Yerba mate beverages are an important source of antioxidants, but there is scarce knowledge about their effects on suppressing fat accumulation. Here, we investigated the compounds present in yerba mate extracts and assessed their effects on Drosophila melanogaster given a high cholesterol diet. LS-ESI-MS analysis showed the presence of matesaponins, phenolic compounds and methylxanthines in all of the examined extracts. In Drosophila, under extract treatment conditions, the mean lifespan was significantly extended from 38 to 43 days, there was an increase in the ability to support induced stress and decrease in lipid peroxidation products. Moreover, yerba mate extracts recovered the glutathione S-transferases (GST) activity and reduced the cholesterol level. Taken together, our results support that extracts can extend lifespan by reducing the detrimental effect of a high-fat diet in D. melanogaster, and this outcome can be associated with the compound content in the extracts. This study improves the understanding of natural interventions that reduce stress-induced oxidative damage, which is fundamental in promoting healthy ageing. |
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Oliveira, Ana Zilda Ceolin Colpo Simões deLima, Maria Eduarda deRosa, Hemerson Silva daLeal, Ana Paula Grilo SuneColares, Chaiane C.Zago, Ana CarolinaSalgueiro, Andréia Caroline FernandesMendez, Andreas Sebastian LoureiroFolmer, VanderleiBertelli, Pablo RicardoMinetto, LucianeSilva, Sidnei Moura e2018-05-05T03:16:10Z20180100-879Xhttp://hdl.handle.net/10183/177561001058364Studies have suggested that total energy intake and diet composition affect lifespan and ageing. A high-fat diet induces oxidative stress and affects the development of diseases. In contrast, antioxidants are capable of reducing its harmful effects. Yerba mate beverages are an important source of antioxidants, but there is scarce knowledge about their effects on suppressing fat accumulation. Here, we investigated the compounds present in yerba mate extracts and assessed their effects on Drosophila melanogaster given a high cholesterol diet. LS-ESI-MS analysis showed the presence of matesaponins, phenolic compounds and methylxanthines in all of the examined extracts. In Drosophila, under extract treatment conditions, the mean lifespan was significantly extended from 38 to 43 days, there was an increase in the ability to support induced stress and decrease in lipid peroxidation products. Moreover, yerba mate extracts recovered the glutathione S-transferases (GST) activity and reduced the cholesterol level. Taken together, our results support that extracts can extend lifespan by reducing the detrimental effect of a high-fat diet in D. melanogaster, and this outcome can be associated with the compound content in the extracts. This study improves the understanding of natural interventions that reduce stress-induced oxidative damage, which is fundamental in promoting healthy ageing.application/pdfengBrazilian journal of medical and biological research. Vol. 51, no. 2 (2018), artigo e6784, 10 p.Ilex paraguariensisEstresse oxidativoDoenças crônicasYerba mateMatesaponinLC-MSAntioxidants compoundsChronic diseasesOxidative stressIlex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat dietinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001058364.pdf001058364.pdfTexto completo (inglês)application/pdf1770511http://www.lume.ufrgs.br/bitstream/10183/177561/1/001058364.pdf2f510abc1e70cf89f45037b9186f858cMD51TEXT001058364.pdf.txt001058364.pdf.txtExtracted Texttext/plain44610http://www.lume.ufrgs.br/bitstream/10183/177561/2/001058364.pdf.txta35745179f6e47ebaa4adb215ee77321MD5210183/1775612018-05-06 02:26:37.045402oai:www.lume.ufrgs.br:10183/177561Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-05-06T05:26:37Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet |
title |
Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet |
spellingShingle |
Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet Oliveira, Ana Zilda Ceolin Colpo Simões de Ilex paraguariensis Estresse oxidativo Doenças crônicas Yerba mate Matesaponin LC-MS Antioxidants compounds Chronic diseases Oxidative stress |
title_short |
Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet |
title_full |
Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet |
title_fullStr |
Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet |
title_full_unstemmed |
Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet |
title_sort |
Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet |
author |
Oliveira, Ana Zilda Ceolin Colpo Simões de |
author_facet |
Oliveira, Ana Zilda Ceolin Colpo Simões de Lima, Maria Eduarda de Rosa, Hemerson Silva da Leal, Ana Paula Grilo Sune Colares, Chaiane C. Zago, Ana Carolina Salgueiro, Andréia Caroline Fernandes Mendez, Andreas Sebastian Loureiro Folmer, Vanderlei Bertelli, Pablo Ricardo Minetto, Luciane Silva, Sidnei Moura e |
author_role |
author |
author2 |
Lima, Maria Eduarda de Rosa, Hemerson Silva da Leal, Ana Paula Grilo Sune Colares, Chaiane C. Zago, Ana Carolina Salgueiro, Andréia Caroline Fernandes Mendez, Andreas Sebastian Loureiro Folmer, Vanderlei Bertelli, Pablo Ricardo Minetto, Luciane Silva, Sidnei Moura e |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Ana Zilda Ceolin Colpo Simões de Lima, Maria Eduarda de Rosa, Hemerson Silva da Leal, Ana Paula Grilo Sune Colares, Chaiane C. Zago, Ana Carolina Salgueiro, Andréia Caroline Fernandes Mendez, Andreas Sebastian Loureiro Folmer, Vanderlei Bertelli, Pablo Ricardo Minetto, Luciane Silva, Sidnei Moura e |
dc.subject.por.fl_str_mv |
Ilex paraguariensis Estresse oxidativo Doenças crônicas |
topic |
Ilex paraguariensis Estresse oxidativo Doenças crônicas Yerba mate Matesaponin LC-MS Antioxidants compounds Chronic diseases Oxidative stress |
dc.subject.eng.fl_str_mv |
Yerba mate Matesaponin LC-MS Antioxidants compounds Chronic diseases Oxidative stress |
description |
Studies have suggested that total energy intake and diet composition affect lifespan and ageing. A high-fat diet induces oxidative stress and affects the development of diseases. In contrast, antioxidants are capable of reducing its harmful effects. Yerba mate beverages are an important source of antioxidants, but there is scarce knowledge about their effects on suppressing fat accumulation. Here, we investigated the compounds present in yerba mate extracts and assessed their effects on Drosophila melanogaster given a high cholesterol diet. LS-ESI-MS analysis showed the presence of matesaponins, phenolic compounds and methylxanthines in all of the examined extracts. In Drosophila, under extract treatment conditions, the mean lifespan was significantly extended from 38 to 43 days, there was an increase in the ability to support induced stress and decrease in lipid peroxidation products. Moreover, yerba mate extracts recovered the glutathione S-transferases (GST) activity and reduced the cholesterol level. Taken together, our results support that extracts can extend lifespan by reducing the detrimental effect of a high-fat diet in D. melanogaster, and this outcome can be associated with the compound content in the extracts. This study improves the understanding of natural interventions that reduce stress-induced oxidative damage, which is fundamental in promoting healthy ageing. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-05-05T03:16:10Z |
dc.date.issued.fl_str_mv |
2018 |
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publishedVersion |
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http://hdl.handle.net/10183/177561 |
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0100-879X |
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001058364 |
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http://hdl.handle.net/10183/177561 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research. Vol. 51, no. 2 (2018), artigo e6784, 10 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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