Major components of metabolic syndrome and adiponectin levels : a cross-sectional study

Detalhes bibliográficos
Autor(a) principal: Frankenberg, Anize Delfino von
Data de Publicação: 2014
Outros Autores: Nascimento, Filipe Valvassori do, Gatelli, Lucas Eduardo, Nedel, Bárbara Limberger, Garcia, Sheila Piccoli, Oliveira, Carolina Soares Viana de, Rosa, Pedro Saddi, Reis, André Fernandes, Canani, Luis Henrique Santos, Gerchman, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/111826
Resumo: Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS. Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured. Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001). Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity.
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spelling Frankenberg, Anize Delfino vonNascimento, Filipe Valvassori doGatelli, Lucas EduardoNedel, Bárbara LimbergerGarcia, Sheila PiccoliOliveira, Carolina Soares Viana deRosa, Pedro SaddiReis, André FernandesCanani, Luis Henrique SantosGerchman, Fernando2015-03-07T01:57:09Z20141758-5996http://hdl.handle.net/10183/111826000953560Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS. Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured. Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001). Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity.application/pdfengDiabetology & metabolic syndrome. São Paulo. Vol. 6 (Feb. 2014), 9p.AdiponectinaSíndrome metabólicaObesidadeAdiponectinMetabolic syndromeObesityMajor components of metabolic syndrome and adiponectin levels : a cross-sectional studyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000953560.pdf000953560.pdfTexto completo (inglês)application/pdf442381http://www.lume.ufrgs.br/bitstream/10183/111826/1/000953560.pdff5c81072b10ae465f492093d916978e5MD51TEXT000953560.pdf.txt000953560.pdf.txtExtracted Texttext/plain44037http://www.lume.ufrgs.br/bitstream/10183/111826/2/000953560.pdf.txt8ac38aef64e22000a61fd0e030460884MD52THUMBNAIL000953560.pdf.jpg000953560.pdf.jpgGenerated Thumbnailimage/jpeg1986http://www.lume.ufrgs.br/bitstream/10183/111826/3/000953560.pdf.jpg3782b5f6269e69865ac907942fb04343MD5310183/1118262023-08-27 03:42:38.338951oai:www.lume.ufrgs.br:10183/111826Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-27T06:42:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
title Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
spellingShingle Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
Frankenberg, Anize Delfino von
Adiponectina
Síndrome metabólica
Obesidade
Adiponectin
Metabolic syndrome
Obesity
title_short Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
title_full Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
title_fullStr Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
title_full_unstemmed Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
title_sort Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
author Frankenberg, Anize Delfino von
author_facet Frankenberg, Anize Delfino von
Nascimento, Filipe Valvassori do
Gatelli, Lucas Eduardo
Nedel, Bárbara Limberger
Garcia, Sheila Piccoli
Oliveira, Carolina Soares Viana de
Rosa, Pedro Saddi
Reis, André Fernandes
Canani, Luis Henrique Santos
Gerchman, Fernando
author_role author
author2 Nascimento, Filipe Valvassori do
Gatelli, Lucas Eduardo
Nedel, Bárbara Limberger
Garcia, Sheila Piccoli
Oliveira, Carolina Soares Viana de
Rosa, Pedro Saddi
Reis, André Fernandes
Canani, Luis Henrique Santos
Gerchman, Fernando
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Frankenberg, Anize Delfino von
Nascimento, Filipe Valvassori do
Gatelli, Lucas Eduardo
Nedel, Bárbara Limberger
Garcia, Sheila Piccoli
Oliveira, Carolina Soares Viana de
Rosa, Pedro Saddi
Reis, André Fernandes
Canani, Luis Henrique Santos
Gerchman, Fernando
dc.subject.por.fl_str_mv Adiponectina
Síndrome metabólica
Obesidade
topic Adiponectina
Síndrome metabólica
Obesidade
Adiponectin
Metabolic syndrome
Obesity
dc.subject.eng.fl_str_mv Adiponectin
Metabolic syndrome
Obesity
description Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS. Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured. Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001). Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity.
publishDate 2014
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dc.relation.ispartof.pt_BR.fl_str_mv Diabetology & metabolic syndrome. São Paulo. Vol. 6 (Feb. 2014), 9p.
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