Major components of metabolic syndrome and adiponectin levels : a cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/111826 |
Resumo: | Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS. Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured. Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001). Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity. |
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Frankenberg, Anize Delfino vonNascimento, Filipe Valvassori doGatelli, Lucas EduardoNedel, Bárbara LimbergerGarcia, Sheila PiccoliOliveira, Carolina Soares Viana deRosa, Pedro SaddiReis, André FernandesCanani, Luis Henrique SantosGerchman, Fernando2015-03-07T01:57:09Z20141758-5996http://hdl.handle.net/10183/111826000953560Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS. Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured. Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001). Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity.application/pdfengDiabetology & metabolic syndrome. São Paulo. Vol. 6 (Feb. 2014), 9p.AdiponectinaSíndrome metabólicaObesidadeAdiponectinMetabolic syndromeObesityMajor components of metabolic syndrome and adiponectin levels : a cross-sectional studyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000953560.pdf000953560.pdfTexto completo (inglês)application/pdf442381http://www.lume.ufrgs.br/bitstream/10183/111826/1/000953560.pdff5c81072b10ae465f492093d916978e5MD51TEXT000953560.pdf.txt000953560.pdf.txtExtracted Texttext/plain44037http://www.lume.ufrgs.br/bitstream/10183/111826/2/000953560.pdf.txt8ac38aef64e22000a61fd0e030460884MD52THUMBNAIL000953560.pdf.jpg000953560.pdf.jpgGenerated Thumbnailimage/jpeg1986http://www.lume.ufrgs.br/bitstream/10183/111826/3/000953560.pdf.jpg3782b5f6269e69865ac907942fb04343MD5310183/1118262023-08-27 03:42:38.338951oai:www.lume.ufrgs.br:10183/111826Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-27T06:42:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Major components of metabolic syndrome and adiponectin levels : a cross-sectional study |
title |
Major components of metabolic syndrome and adiponectin levels : a cross-sectional study |
spellingShingle |
Major components of metabolic syndrome and adiponectin levels : a cross-sectional study Frankenberg, Anize Delfino von Adiponectina Síndrome metabólica Obesidade Adiponectin Metabolic syndrome Obesity |
title_short |
Major components of metabolic syndrome and adiponectin levels : a cross-sectional study |
title_full |
Major components of metabolic syndrome and adiponectin levels : a cross-sectional study |
title_fullStr |
Major components of metabolic syndrome and adiponectin levels : a cross-sectional study |
title_full_unstemmed |
Major components of metabolic syndrome and adiponectin levels : a cross-sectional study |
title_sort |
Major components of metabolic syndrome and adiponectin levels : a cross-sectional study |
author |
Frankenberg, Anize Delfino von |
author_facet |
Frankenberg, Anize Delfino von Nascimento, Filipe Valvassori do Gatelli, Lucas Eduardo Nedel, Bárbara Limberger Garcia, Sheila Piccoli Oliveira, Carolina Soares Viana de Rosa, Pedro Saddi Reis, André Fernandes Canani, Luis Henrique Santos Gerchman, Fernando |
author_role |
author |
author2 |
Nascimento, Filipe Valvassori do Gatelli, Lucas Eduardo Nedel, Bárbara Limberger Garcia, Sheila Piccoli Oliveira, Carolina Soares Viana de Rosa, Pedro Saddi Reis, André Fernandes Canani, Luis Henrique Santos Gerchman, Fernando |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Frankenberg, Anize Delfino von Nascimento, Filipe Valvassori do Gatelli, Lucas Eduardo Nedel, Bárbara Limberger Garcia, Sheila Piccoli Oliveira, Carolina Soares Viana de Rosa, Pedro Saddi Reis, André Fernandes Canani, Luis Henrique Santos Gerchman, Fernando |
dc.subject.por.fl_str_mv |
Adiponectina Síndrome metabólica Obesidade |
topic |
Adiponectina Síndrome metabólica Obesidade Adiponectin Metabolic syndrome Obesity |
dc.subject.eng.fl_str_mv |
Adiponectin Metabolic syndrome Obesity |
description |
Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. The purpose of the study was to investigate the relationship between adiponectin levels and MS. Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clínicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured. Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001). Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-03-07T01:57:09Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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info:eu-repo/semantics/publishedVersion |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/111826 |
dc.identifier.issn.pt_BR.fl_str_mv |
1758-5996 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000953560 |
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http://hdl.handle.net/10183/111826 |
dc.language.iso.fl_str_mv |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Diabetology & metabolic syndrome. São Paulo. Vol. 6 (Feb. 2014), 9p. |
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openAccess |
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