Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/206429 |
Resumo: | Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance – abnormalities of glucose metabolism typically found in subjects with obesity – are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2. In addition, the impact of dietary lipids in the circulating levels of adiponectin will be addressed. According to the literature, circulating adiponectin levels seem to decrease as the number of MS components increases. Lower adiponectin concentrations are associated with higher intra-abdominal fat content. Therefore, adiponectin could link intra-abdominal fat with insulin resistance and development of MS. Therapeutic strategies that target the MS and its components, such as lifestyle modification through physical activity and weight loss, have been shown to increase adiponectin concentrations. Possible roles of diets containing either low or high amounts of fat, or different types of fat, have been analyzed in several studies, with heterogeneous results. Supplementation with n-3 PUFA modestly increases adiponectin levels, whereas conjugated linoleic acid supplementation appears to reduce concentrations when compared with unsaturated fatty acid supplementation used as an active placebo |
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Frankenberg, Anize Delfino vonReis, André FernandesGerchman, Fernando2020-03-04T04:20:21Z20172359-4292http://hdl.handle.net/10183/206429001110514Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance – abnormalities of glucose metabolism typically found in subjects with obesity – are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2. In addition, the impact of dietary lipids in the circulating levels of adiponectin will be addressed. According to the literature, circulating adiponectin levels seem to decrease as the number of MS components increases. Lower adiponectin concentrations are associated with higher intra-abdominal fat content. Therefore, adiponectin could link intra-abdominal fat with insulin resistance and development of MS. Therapeutic strategies that target the MS and its components, such as lifestyle modification through physical activity and weight loss, have been shown to increase adiponectin concentrations. Possible roles of diets containing either low or high amounts of fat, or different types of fat, have been analyzed in several studies, with heterogeneous results. Supplementation with n-3 PUFA modestly increases adiponectin levels, whereas conjugated linoleic acid supplementation appears to reduce concentrations when compared with unsaturated fatty acid supplementation used as an active placeboapplication/pdfengArchives of endocrinology and metabolism. São Paulo, SP. Vol. 61, n. 6 (2017), p. 614-622Diabetes mellitus tipo 2AdiponectinaSíndrome metabólicaRevisãoAdiponectinMetabolic syndromeType 2 diabetesRelationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature reviewinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001110514.pdf.txt001110514.pdf.txtExtracted Texttext/plain45361http://www.lume.ufrgs.br/bitstream/10183/206429/2/001110514.pdf.txtd7447edaa52c00c7ab0058b847b0a458MD52ORIGINAL001110514.pdfTexto completo (inglês)application/pdf409496http://www.lume.ufrgs.br/bitstream/10183/206429/1/001110514.pdf905f5ec0b9c00f7c4eed7cb5adc694f6MD5110183/2064292020-03-05 04:18:06.293604oai:www.lume.ufrgs.br:10183/206429Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-03-05T07:18:06Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review |
title |
Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review |
spellingShingle |
Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review Frankenberg, Anize Delfino von Diabetes mellitus tipo 2 Adiponectina Síndrome metabólica Revisão Adiponectin Metabolic syndrome Type 2 diabetes |
title_short |
Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review |
title_full |
Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review |
title_fullStr |
Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review |
title_full_unstemmed |
Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review |
title_sort |
Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes : a literature review |
author |
Frankenberg, Anize Delfino von |
author_facet |
Frankenberg, Anize Delfino von Reis, André Fernandes Gerchman, Fernando |
author_role |
author |
author2 |
Reis, André Fernandes Gerchman, Fernando |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Frankenberg, Anize Delfino von Reis, André Fernandes Gerchman, Fernando |
dc.subject.por.fl_str_mv |
Diabetes mellitus tipo 2 Adiponectina Síndrome metabólica Revisão |
topic |
Diabetes mellitus tipo 2 Adiponectina Síndrome metabólica Revisão Adiponectin Metabolic syndrome Type 2 diabetes |
dc.subject.eng.fl_str_mv |
Adiponectin Metabolic syndrome Type 2 diabetes |
description |
Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance – abnormalities of glucose metabolism typically found in subjects with obesity – are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2. In addition, the impact of dietary lipids in the circulating levels of adiponectin will be addressed. According to the literature, circulating adiponectin levels seem to decrease as the number of MS components increases. Lower adiponectin concentrations are associated with higher intra-abdominal fat content. Therefore, adiponectin could link intra-abdominal fat with insulin resistance and development of MS. Therapeutic strategies that target the MS and its components, such as lifestyle modification through physical activity and weight loss, have been shown to increase adiponectin concentrations. Possible roles of diets containing either low or high amounts of fat, or different types of fat, have been analyzed in several studies, with heterogeneous results. Supplementation with n-3 PUFA modestly increases adiponectin levels, whereas conjugated linoleic acid supplementation appears to reduce concentrations when compared with unsaturated fatty acid supplementation used as an active placebo |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
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2020-03-04T04:20:21Z |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Archives of endocrinology and metabolism. São Paulo, SP. Vol. 61, n. 6 (2017), p. 614-622 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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