Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/245621 |
Resumo: | Background: Rheumatoid arthritis (RA) is an autoimmune, inflammatory and chronic disease that may lead to loss of muscle mass, muscle strength and decreased functionality. Our objectives are to assess the quadriceps muscle morphology by ultrasound (MU) and verify its associations with clinical features, muscle strength and physical function in RA patients. Methods: In this cross-sectional study, RA women ( 18 years) were included. Morphological parameters in quadriceps muscle consisted of the muscle thickness and pennation angle of rectus femoris (RF), vastus intermedius (VI) and vastus lateralis (VL). RA activity was measured by a 28-joint disease activity score (DAS28), muscle strength by handgrip and chair stand tests, and physical function by health assessment questionnaire (HAQ), timed-up-and-go (TUG) test and short physical performance battery (SPPB). Results: Fifty-five patients were included (age: 56.73 9.46 years; DAS28: 3.08 1.29). Muscle thickness in RF, VI and VL were negatively associated with age (RF, p < 0.001; VI, p = 0.013; VL, p = 0.002) and disease duration (RF, p < 0.001; VI, p = 0.005; VL, p = 0.001), and were positively associated with handgrip strength (RF, p = 0.015; VI, p = 0.022; VL, p = 0.013). In addition, decreased muscle thickness in VI (p = 0.035) and a smaller pennation angle in RF (p = 0.030) were associated with higher DAS-28 scores. Conclusion: Quadriceps muscle morphology by ultrasound appears to be affected by age, disease duration, disease activity and muscle strength in patients with RA. MU can be a useful method to evaluate the impact of the disease on skeletal muscle. |
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Santos, Leonardo Peterson dosEspírito Santo, Rafaela Cavalheiro doPena, ÉmersonDória, Lucas DenardiHax, VanessaBrenol, Claiton ViegasMonticielo, Odirlei AndréChakr, Rafael Mendonça da SilvaXavier, Ricardo Machado2022-07-28T04:45:42Z20212075-4418http://hdl.handle.net/10183/245621001146368Background: Rheumatoid arthritis (RA) is an autoimmune, inflammatory and chronic disease that may lead to loss of muscle mass, muscle strength and decreased functionality. Our objectives are to assess the quadriceps muscle morphology by ultrasound (MU) and verify its associations with clinical features, muscle strength and physical function in RA patients. Methods: In this cross-sectional study, RA women ( 18 years) were included. Morphological parameters in quadriceps muscle consisted of the muscle thickness and pennation angle of rectus femoris (RF), vastus intermedius (VI) and vastus lateralis (VL). RA activity was measured by a 28-joint disease activity score (DAS28), muscle strength by handgrip and chair stand tests, and physical function by health assessment questionnaire (HAQ), timed-up-and-go (TUG) test and short physical performance battery (SPPB). Results: Fifty-five patients were included (age: 56.73 9.46 years; DAS28: 3.08 1.29). Muscle thickness in RF, VI and VL were negatively associated with age (RF, p < 0.001; VI, p = 0.013; VL, p = 0.002) and disease duration (RF, p < 0.001; VI, p = 0.005; VL, p = 0.001), and were positively associated with handgrip strength (RF, p = 0.015; VI, p = 0.022; VL, p = 0.013). In addition, decreased muscle thickness in VI (p = 0.035) and a smaller pennation angle in RF (p = 0.030) were associated with higher DAS-28 scores. Conclusion: Quadriceps muscle morphology by ultrasound appears to be affected by age, disease duration, disease activity and muscle strength in patients with RA. MU can be a useful method to evaluate the impact of the disease on skeletal muscle.application/pdfengDiagnostics. Basel. Vol. 11 (2021), 2014, 15 p.Artrite reumatóideMúsculosSarcopeniaAntropometriaForça muscularMulheresRheumatoid arthritisMuscle massUltrasoundMuscle strengthFunctionalitySarcopeniaMorphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001146368.pdf.txt001146368.pdf.txtExtracted Texttext/plain51045http://www.lume.ufrgs.br/bitstream/10183/245621/2/001146368.pdf.txt624e4cc11021eae62d6882e872e67aa3MD52ORIGINAL001146368.pdfTexto completo (inglês)application/pdf2574604http://www.lume.ufrgs.br/bitstream/10183/245621/1/001146368.pdfac82b4a534db745fc0c37a262e71e3d1MD5110183/2456212022-07-29 04:51:12.363406oai:www.lume.ufrgs.br:10183/245621Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-07-29T07:51:12Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study |
title |
Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study |
spellingShingle |
Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study Santos, Leonardo Peterson dos Artrite reumatóide Músculos Sarcopenia Antropometria Força muscular Mulheres Rheumatoid arthritis Muscle mass Ultrasound Muscle strength Functionality Sarcopenia |
title_short |
Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study |
title_full |
Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study |
title_fullStr |
Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study |
title_full_unstemmed |
Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study |
title_sort |
Morphological parameters in quadriceps muscle were associated with clinical features and muscle strength of women with rheumatoid arthritis : a cross-sectional study |
author |
Santos, Leonardo Peterson dos |
author_facet |
Santos, Leonardo Peterson dos Espírito Santo, Rafaela Cavalheiro do Pena, Émerson Dória, Lucas Denardi Hax, Vanessa Brenol, Claiton Viegas Monticielo, Odirlei André Chakr, Rafael Mendonça da Silva Xavier, Ricardo Machado |
author_role |
author |
author2 |
Espírito Santo, Rafaela Cavalheiro do Pena, Émerson Dória, Lucas Denardi Hax, Vanessa Brenol, Claiton Viegas Monticielo, Odirlei André Chakr, Rafael Mendonça da Silva Xavier, Ricardo Machado |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Leonardo Peterson dos Espírito Santo, Rafaela Cavalheiro do Pena, Émerson Dória, Lucas Denardi Hax, Vanessa Brenol, Claiton Viegas Monticielo, Odirlei André Chakr, Rafael Mendonça da Silva Xavier, Ricardo Machado |
dc.subject.por.fl_str_mv |
Artrite reumatóide Músculos Sarcopenia Antropometria Força muscular Mulheres |
topic |
Artrite reumatóide Músculos Sarcopenia Antropometria Força muscular Mulheres Rheumatoid arthritis Muscle mass Ultrasound Muscle strength Functionality Sarcopenia |
dc.subject.eng.fl_str_mv |
Rheumatoid arthritis Muscle mass Ultrasound Muscle strength Functionality Sarcopenia |
description |
Background: Rheumatoid arthritis (RA) is an autoimmune, inflammatory and chronic disease that may lead to loss of muscle mass, muscle strength and decreased functionality. Our objectives are to assess the quadriceps muscle morphology by ultrasound (MU) and verify its associations with clinical features, muscle strength and physical function in RA patients. Methods: In this cross-sectional study, RA women ( 18 years) were included. Morphological parameters in quadriceps muscle consisted of the muscle thickness and pennation angle of rectus femoris (RF), vastus intermedius (VI) and vastus lateralis (VL). RA activity was measured by a 28-joint disease activity score (DAS28), muscle strength by handgrip and chair stand tests, and physical function by health assessment questionnaire (HAQ), timed-up-and-go (TUG) test and short physical performance battery (SPPB). Results: Fifty-five patients were included (age: 56.73 9.46 years; DAS28: 3.08 1.29). Muscle thickness in RF, VI and VL were negatively associated with age (RF, p < 0.001; VI, p = 0.013; VL, p = 0.002) and disease duration (RF, p < 0.001; VI, p = 0.005; VL, p = 0.001), and were positively associated with handgrip strength (RF, p = 0.015; VI, p = 0.022; VL, p = 0.013). In addition, decreased muscle thickness in VI (p = 0.035) and a smaller pennation angle in RF (p = 0.030) were associated with higher DAS-28 scores. Conclusion: Quadriceps muscle morphology by ultrasound appears to be affected by age, disease duration, disease activity and muscle strength in patients with RA. MU can be a useful method to evaluate the impact of the disease on skeletal muscle. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-07-28T04:45:42Z |
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Estrangeiro info:eu-repo/semantics/article |
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dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/245621 |
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2075-4418 |
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001146368 |
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2075-4418 001146368 |
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http://hdl.handle.net/10183/245621 |
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eng |
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Diagnostics. Basel. Vol. 11 (2021), 2014, 15 p. |
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