Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/108271 |
Resumo: | Poly(2-(dimethylamino)ethylmethacrylate-b-methymethacrylate) (PDMAEMA-b-PMMA) poly(2- (dimethylamino)ethylmethacrylate-b-vinylcaprolactam-b-(2-(dimethylamino)ethyl methacrylate) (PDMAEMA-b-PVCL-b-PDMAEMA) and poly(vinylcaprolactam-b-(2-(dimethylamino) ethylmethacrylate-b-vinylcaprolactam) (PVCL-b-PDMAEMA-b-PVCL) block copolymers were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization, and the effect of the solution pH on the particle size was investigated. In the case of PDMAEMA-b-PMMA, PDMAEMA was first synthesized using 2-cyanoprop-2-yl dithiobenzoate (CPDB) as a chain transfer agent (CTA), which was subsequently used for the RAFT polymerization of MMA. The triblock copolymers were obtained using PDMAEMA or PVCL as macro-CTAs prepared using dibenzyl trithiocarbonate (DBTTC) as a bifunctional RAFT agent. The structure and formation of the copolymers was confirmed through 1H NMR and SEC analysis. The particle size varied considerably depending on the pH of the aqueous solutions of copolymers indicating that these materials could be potential candidates for biomedical applications. |
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Tebaldi, Marli LuizaLeal, Débora AbrantesMontoro, Sérgio RobertoPetzhold, Cesar Liberato2014-12-13T02:18:59Z20141516-1439http://hdl.handle.net/10183/108271000947390Poly(2-(dimethylamino)ethylmethacrylate-b-methymethacrylate) (PDMAEMA-b-PMMA) poly(2- (dimethylamino)ethylmethacrylate-b-vinylcaprolactam-b-(2-(dimethylamino)ethyl methacrylate) (PDMAEMA-b-PVCL-b-PDMAEMA) and poly(vinylcaprolactam-b-(2-(dimethylamino) ethylmethacrylate-b-vinylcaprolactam) (PVCL-b-PDMAEMA-b-PVCL) block copolymers were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization, and the effect of the solution pH on the particle size was investigated. In the case of PDMAEMA-b-PMMA, PDMAEMA was first synthesized using 2-cyanoprop-2-yl dithiobenzoate (CPDB) as a chain transfer agent (CTA), which was subsequently used for the RAFT polymerization of MMA. The triblock copolymers were obtained using PDMAEMA or PVCL as macro-CTAs prepared using dibenzyl trithiocarbonate (DBTTC) as a bifunctional RAFT agent. The structure and formation of the copolymers was confirmed through 1H NMR and SEC analysis. The particle size varied considerably depending on the pH of the aqueous solutions of copolymers indicating that these materials could be potential candidates for biomedical applications.application/pdfengMaterials research : ibero-american journal of materials. São Carlos. Vol. 17, supl. 1 (2014), p. 191-196Copolímeros em blocoPolimerizaçãopoly(dimethylaminoethyl methacrylate)Reversible additionfragmentation chain transfer (RAFT) polymerizationpoly(methylmethacrylate)poly(vinylcaprolactam)Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systemsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000947390.pdf000947390.pdfTexto completo (inglês)application/pdf1245805http://www.lume.ufrgs.br/bitstream/10183/108271/1/000947390.pdffff1a2da018982ff566dca30ab262f42MD51TEXT000947390.pdf.txt000947390.pdf.txtExtracted Texttext/plain25156http://www.lume.ufrgs.br/bitstream/10183/108271/2/000947390.pdf.txt2700e31c63b0b4f8b2d50e0bad7caa28MD52THUMBNAIL000947390.pdf.jpg000947390.pdf.jpgGenerated Thumbnailimage/jpeg1812http://www.lume.ufrgs.br/bitstream/10183/108271/3/000947390.pdf.jpgd58eb7d471e32493ccf90eb5b259bd05MD5310183/1082712018-10-22 09:02:04.222oai:www.lume.ufrgs.br:10183/108271Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-22T12:02:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems |
title |
Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems |
spellingShingle |
Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems Tebaldi, Marli Luiza Copolímeros em bloco Polimerização poly(dimethylaminoethyl methacrylate) Reversible addition fragmentation chain transfer (RAFT) polymerization poly(methylmethacrylate) poly(vinylcaprolactam) |
title_short |
Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems |
title_full |
Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems |
title_fullStr |
Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems |
title_full_unstemmed |
Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems |
title_sort |
Synthesis of stimuli-sensitive copolymers by RAFT polymerization : potential candidates as drug delivery systems |
author |
Tebaldi, Marli Luiza |
author_facet |
Tebaldi, Marli Luiza Leal, Débora Abrantes Montoro, Sérgio Roberto Petzhold, Cesar Liberato |
author_role |
author |
author2 |
Leal, Débora Abrantes Montoro, Sérgio Roberto Petzhold, Cesar Liberato |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Tebaldi, Marli Luiza Leal, Débora Abrantes Montoro, Sérgio Roberto Petzhold, Cesar Liberato |
dc.subject.por.fl_str_mv |
Copolímeros em bloco Polimerização |
topic |
Copolímeros em bloco Polimerização poly(dimethylaminoethyl methacrylate) Reversible addition fragmentation chain transfer (RAFT) polymerization poly(methylmethacrylate) poly(vinylcaprolactam) |
dc.subject.eng.fl_str_mv |
poly(dimethylaminoethyl methacrylate) Reversible addition fragmentation chain transfer (RAFT) polymerization poly(methylmethacrylate) poly(vinylcaprolactam) |
description |
Poly(2-(dimethylamino)ethylmethacrylate-b-methymethacrylate) (PDMAEMA-b-PMMA) poly(2- (dimethylamino)ethylmethacrylate-b-vinylcaprolactam-b-(2-(dimethylamino)ethyl methacrylate) (PDMAEMA-b-PVCL-b-PDMAEMA) and poly(vinylcaprolactam-b-(2-(dimethylamino) ethylmethacrylate-b-vinylcaprolactam) (PVCL-b-PDMAEMA-b-PVCL) block copolymers were obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization, and the effect of the solution pH on the particle size was investigated. In the case of PDMAEMA-b-PMMA, PDMAEMA was first synthesized using 2-cyanoprop-2-yl dithiobenzoate (CPDB) as a chain transfer agent (CTA), which was subsequently used for the RAFT polymerization of MMA. The triblock copolymers were obtained using PDMAEMA or PVCL as macro-CTAs prepared using dibenzyl trithiocarbonate (DBTTC) as a bifunctional RAFT agent. The structure and formation of the copolymers was confirmed through 1H NMR and SEC analysis. The particle size varied considerably depending on the pH of the aqueous solutions of copolymers indicating that these materials could be potential candidates for biomedical applications. |
publishDate |
2014 |
dc.date.accessioned.fl_str_mv |
2014-12-13T02:18:59Z |
dc.date.issued.fl_str_mv |
2014 |
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http://hdl.handle.net/10183/108271 |
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1516-1439 |
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000947390 |
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http://hdl.handle.net/10183/108271 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Materials research : ibero-american journal of materials. São Carlos. Vol. 17, supl. 1 (2014), p. 191-196 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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