Serum and urinary progranulin in diabetic kidney disease
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/149763 |
Resumo: | Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). There are scarce data regarding progranulin and kidney disease, but there are some data linking diabetic kidney disease (DKD) and increased progranulin levels. We aimed to better describe the relationship between serum and urinary progranulin levels and DKD in T2DM. This is a case-control study including four groups of subjects: 1) Advanced DKD cases: T2DM patients with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2; 2) Albuminuric DKD cases: T2DM patients with urinary albumin excretion (UAE) 30 mg/g creatinine and eGFR 60 mL/min/1.73m2; 3) Diabetic controls: T2DM patients with UAE <30 mg/g creatinine and eGFR 60 mL/min/1.73m2; and 4) Non-diabetic controls: individuals without T2DM. Progranulin was determined by enzymelinked immunosorbent assay. One hundred and fourteen patients were included (23 advanced DKD cases, 25 albuminuric DKD cases, 40 diabetic controls and 26 non-diabetic controls). Serum progranulin was increased in advanced DKD compared to other groups [70.84 (59.04±83.16) vs. albuminuric cases 57.16 (42.24±67.38), diabetic controls 57.28 (42.08±70.47) and non-diabetic controls 44.54 (41.44±53.32) ng/mL; p<0.001]. Urinary progranulin was decreased in advanced DKD cases compared to albuminuric cases [10.62 (6.30±16.08) vs. 20.94 (12.35±30.22); diabetic controls 14.06 (9.88±20.82) and non-diabetic controls 13.51 (7.94±24.36) ng/mL; p = 0.017]. There was a positive correlation between serum progranulin and body mass index (r = 0.27; p = 0.004), waist circumference (r = 0.25; p = 0.007); body fat percentage (r = 0.20; p = 0.042), high-sensitive C reactive protein (r = 0.35; p<0.001) and interleukin-6 (r = 0.37; p<0.001) and a negative correlation with eGFR (r = -0.22; p = 0.023). Urinary progranulin was positively associated with albuminuria (r = 0.25; p = 0.010). In conclusion, progranulin is affected by a decrease in eGFR, being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation. |
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Nicoletto, Bruna BellincantaKrolikowski, Thaiana CirinoCrispim, DaisyCanani, Luis Henrique Santos2016-11-19T02:17:00Z20161932-6203http://hdl.handle.net/10183/149763001007000Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). There are scarce data regarding progranulin and kidney disease, but there are some data linking diabetic kidney disease (DKD) and increased progranulin levels. We aimed to better describe the relationship between serum and urinary progranulin levels and DKD in T2DM. This is a case-control study including four groups of subjects: 1) Advanced DKD cases: T2DM patients with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2; 2) Albuminuric DKD cases: T2DM patients with urinary albumin excretion (UAE) 30 mg/g creatinine and eGFR 60 mL/min/1.73m2; 3) Diabetic controls: T2DM patients with UAE <30 mg/g creatinine and eGFR 60 mL/min/1.73m2; and 4) Non-diabetic controls: individuals without T2DM. Progranulin was determined by enzymelinked immunosorbent assay. One hundred and fourteen patients were included (23 advanced DKD cases, 25 albuminuric DKD cases, 40 diabetic controls and 26 non-diabetic controls). Serum progranulin was increased in advanced DKD compared to other groups [70.84 (59.04±83.16) vs. albuminuric cases 57.16 (42.24±67.38), diabetic controls 57.28 (42.08±70.47) and non-diabetic controls 44.54 (41.44±53.32) ng/mL; p<0.001]. Urinary progranulin was decreased in advanced DKD cases compared to albuminuric cases [10.62 (6.30±16.08) vs. 20.94 (12.35±30.22); diabetic controls 14.06 (9.88±20.82) and non-diabetic controls 13.51 (7.94±24.36) ng/mL; p = 0.017]. There was a positive correlation between serum progranulin and body mass index (r = 0.27; p = 0.004), waist circumference (r = 0.25; p = 0.007); body fat percentage (r = 0.20; p = 0.042), high-sensitive C reactive protein (r = 0.35; p<0.001) and interleukin-6 (r = 0.37; p<0.001) and a negative correlation with eGFR (r = -0.22; p = 0.023). Urinary progranulin was positively associated with albuminuria (r = 0.25; p = 0.010). In conclusion, progranulin is affected by a decrease in eGFR, being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation.application/pdfengPLoS ONE. San Francisco. Vol. 11, no. 10 (Oct. 2016), e0165177, 15 p.Nefropatias diabéticasDiabetes mellitus tipo 2ObesidadeSerum and urinary progranulin in diabetic kidney diseaseEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001007000.pdf001007000.pdfTexto completo (inglês)application/pdf1414804http://www.lume.ufrgs.br/bitstream/10183/149763/1/001007000.pdff7ca70ffa37fdce14e2ed441cf6eafe4MD51TEXT001007000.pdf.txt001007000.pdf.txtExtracted Texttext/plain37769http://www.lume.ufrgs.br/bitstream/10183/149763/2/001007000.pdf.txtca31fade856172a4435f75d8184bf402MD52THUMBNAIL001007000.pdf.jpg001007000.pdf.jpgGenerated Thumbnailimage/jpeg2060http://www.lume.ufrgs.br/bitstream/10183/149763/3/001007000.pdf.jpgb29ba1757e44fa2ad214e3debc1ef40cMD5310183/1497632023-05-20 03:50:35.445475oai:www.lume.ufrgs.br:10183/149763Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-20T06:50:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Serum and urinary progranulin in diabetic kidney disease |
title |
Serum and urinary progranulin in diabetic kidney disease |
spellingShingle |
Serum and urinary progranulin in diabetic kidney disease Nicoletto, Bruna Bellincanta Nefropatias diabéticas Diabetes mellitus tipo 2 Obesidade |
title_short |
Serum and urinary progranulin in diabetic kidney disease |
title_full |
Serum and urinary progranulin in diabetic kidney disease |
title_fullStr |
Serum and urinary progranulin in diabetic kidney disease |
title_full_unstemmed |
Serum and urinary progranulin in diabetic kidney disease |
title_sort |
Serum and urinary progranulin in diabetic kidney disease |
author |
Nicoletto, Bruna Bellincanta |
author_facet |
Nicoletto, Bruna Bellincanta Krolikowski, Thaiana Cirino Crispim, Daisy Canani, Luis Henrique Santos |
author_role |
author |
author2 |
Krolikowski, Thaiana Cirino Crispim, Daisy Canani, Luis Henrique Santos |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Nicoletto, Bruna Bellincanta Krolikowski, Thaiana Cirino Crispim, Daisy Canani, Luis Henrique Santos |
dc.subject.por.fl_str_mv |
Nefropatias diabéticas Diabetes mellitus tipo 2 Obesidade |
topic |
Nefropatias diabéticas Diabetes mellitus tipo 2 Obesidade |
description |
Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). There are scarce data regarding progranulin and kidney disease, but there are some data linking diabetic kidney disease (DKD) and increased progranulin levels. We aimed to better describe the relationship between serum and urinary progranulin levels and DKD in T2DM. This is a case-control study including four groups of subjects: 1) Advanced DKD cases: T2DM patients with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2; 2) Albuminuric DKD cases: T2DM patients with urinary albumin excretion (UAE) 30 mg/g creatinine and eGFR 60 mL/min/1.73m2; 3) Diabetic controls: T2DM patients with UAE <30 mg/g creatinine and eGFR 60 mL/min/1.73m2; and 4) Non-diabetic controls: individuals without T2DM. Progranulin was determined by enzymelinked immunosorbent assay. One hundred and fourteen patients were included (23 advanced DKD cases, 25 albuminuric DKD cases, 40 diabetic controls and 26 non-diabetic controls). Serum progranulin was increased in advanced DKD compared to other groups [70.84 (59.04±83.16) vs. albuminuric cases 57.16 (42.24±67.38), diabetic controls 57.28 (42.08±70.47) and non-diabetic controls 44.54 (41.44±53.32) ng/mL; p<0.001]. Urinary progranulin was decreased in advanced DKD cases compared to albuminuric cases [10.62 (6.30±16.08) vs. 20.94 (12.35±30.22); diabetic controls 14.06 (9.88±20.82) and non-diabetic controls 13.51 (7.94±24.36) ng/mL; p = 0.017]. There was a positive correlation between serum progranulin and body mass index (r = 0.27; p = 0.004), waist circumference (r = 0.25; p = 0.007); body fat percentage (r = 0.20; p = 0.042), high-sensitive C reactive protein (r = 0.35; p<0.001) and interleukin-6 (r = 0.37; p<0.001) and a negative correlation with eGFR (r = -0.22; p = 0.023). Urinary progranulin was positively associated with albuminuria (r = 0.25; p = 0.010). In conclusion, progranulin is affected by a decrease in eGFR, being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation. |
publishDate |
2016 |
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2016 |
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PLoS ONE. San Francisco. Vol. 11, no. 10 (Oct. 2016), e0165177, 15 p. |
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