FRMD3 gene : its role in diabetic kidney disease : a narrative review

Detalhes bibliográficos
Autor(a) principal: Buffon, Marjoriê Piuco
Data de Publicação: 2015
Outros Autores: Sortica, Denise Alves, Gerchman, Fernando, Crispim, Daisy, Canani, Luis Henrique Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/196750
Resumo: Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.
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spelling Buffon, Marjoriê PiucoSortica, Denise AlvesGerchman, FernandoCrispim, DaisyCanani, Luis Henrique Santos2019-07-10T02:34:44Z20151758-5996http://hdl.handle.net/10183/196750000984292Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.application/pdfengDiabetology and Metabolic Syndrome. São Paulo. Vol. 7, n. 118 (2015), 10 p.Diabetes mellitusNefropatiasGenéticaFRMD3 gene : its role in diabetic kidney disease : a narrative reviewEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000984292.pdf.txt000984292.pdf.txtExtracted Texttext/plain39917http://www.lume.ufrgs.br/bitstream/10183/196750/2/000984292.pdf.txtc77cd0746d19d118d4a70b407e006486MD52ORIGINAL000984292.pdfTexto completo (inglês)application/pdf3124788http://www.lume.ufrgs.br/bitstream/10183/196750/1/000984292.pdf01aa20ab2d03cd62a3eca7d3ad89daa5MD5110183/1967502019-07-11 02:35:22.606574oai:www.lume.ufrgs.br:10183/196750Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-07-11T05:35:22Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv FRMD3 gene : its role in diabetic kidney disease : a narrative review
title FRMD3 gene : its role in diabetic kidney disease : a narrative review
spellingShingle FRMD3 gene : its role in diabetic kidney disease : a narrative review
Buffon, Marjoriê Piuco
Diabetes mellitus
Nefropatias
Genética
title_short FRMD3 gene : its role in diabetic kidney disease : a narrative review
title_full FRMD3 gene : its role in diabetic kidney disease : a narrative review
title_fullStr FRMD3 gene : its role in diabetic kidney disease : a narrative review
title_full_unstemmed FRMD3 gene : its role in diabetic kidney disease : a narrative review
title_sort FRMD3 gene : its role in diabetic kidney disease : a narrative review
author Buffon, Marjoriê Piuco
author_facet Buffon, Marjoriê Piuco
Sortica, Denise Alves
Gerchman, Fernando
Crispim, Daisy
Canani, Luis Henrique Santos
author_role author
author2 Sortica, Denise Alves
Gerchman, Fernando
Crispim, Daisy
Canani, Luis Henrique Santos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Buffon, Marjoriê Piuco
Sortica, Denise Alves
Gerchman, Fernando
Crispim, Daisy
Canani, Luis Henrique Santos
dc.subject.por.fl_str_mv Diabetes mellitus
Nefropatias
Genética
topic Diabetes mellitus
Nefropatias
Genética
description Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-07-10T02:34:44Z
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Diabetology and Metabolic Syndrome. São Paulo. Vol. 7, n. 118 (2015), 10 p.
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