Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia

Detalhes bibliográficos
Autor(a) principal: Seligman, Renato
Data de Publicação: 2008
Outros Autores: Papassotiriou, Jana, Morgenthaler, Nils G., Meisner, Michael, Teixeira, Paulo Jose Zimermann
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/21550
Resumo: Background The present study sought to investigate the correlation of copeptin with the severity of septic status in patients with ventilator-associated pneumonia (VAP), and to analyze the usefulness of copeptin as a predictor of mortality in VAP. Methods The prospective observational cohort study was conducted in a teaching hospital. The subjects were 71 patients consecutively admitted to the intensive care unit from October 2003 to August 2005 who developed VAP. Copeptin levels were determined on day 0 and day 4 of VAP. Patients were followed for 28 days after the diagnosis, when they were considered survivors. Patients who died before day 28 were classified as nonsurvivors. There were no interventions. Results Copeptin levels increased from sepsis to severe sepsis and septic shock both on day 0 and day 4 (P = 0.001 and P = 0.009, respectively). Variables included in the univariable logistic regression analysis for mortality were age, gender, Acute Physiology and Chronic Health Evaluation II score and ln copeptin on day 0 and day 4. Mortality was directly related to ln copeptin levels on day 0 and day 4, with odds ratios of 2.32 (95% confidence interval, 1.25 to 4.29) and 2.31 (95% confidence interval, 1.25 to 4.25), respectively. In a multivariable logistic regression model for mortality, only ln copeptin on day 0 with odds ratio 1.97 (95% confidence interval, 1.06 to 3.69) and ln copeptin on day 4 with odds ratio 2.39 (95% confidence interval, 1.24 to 4.62) remained significant. Conclusion Our data demonstrate that copeptin levels increase progressively with the severity of sepsis and are independent predictors of mortality in VAP.
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spelling Seligman, RenatoPapassotiriou, JanaMorgenthaler, Nils G.Meisner, MichaelTeixeira, Paulo Jose Zimermann2010-05-05T04:15:50Z20081364-8535http://hdl.handle.net/10183/21550000655073Background The present study sought to investigate the correlation of copeptin with the severity of septic status in patients with ventilator-associated pneumonia (VAP), and to analyze the usefulness of copeptin as a predictor of mortality in VAP. Methods The prospective observational cohort study was conducted in a teaching hospital. The subjects were 71 patients consecutively admitted to the intensive care unit from October 2003 to August 2005 who developed VAP. Copeptin levels were determined on day 0 and day 4 of VAP. Patients were followed for 28 days after the diagnosis, when they were considered survivors. Patients who died before day 28 were classified as nonsurvivors. There were no interventions. Results Copeptin levels increased from sepsis to severe sepsis and septic shock both on day 0 and day 4 (P = 0.001 and P = 0.009, respectively). Variables included in the univariable logistic regression analysis for mortality were age, gender, Acute Physiology and Chronic Health Evaluation II score and ln copeptin on day 0 and day 4. Mortality was directly related to ln copeptin levels on day 0 and day 4, with odds ratios of 2.32 (95% confidence interval, 1.25 to 4.29) and 2.31 (95% confidence interval, 1.25 to 4.25), respectively. In a multivariable logistic regression model for mortality, only ln copeptin on day 0 with odds ratio 1.97 (95% confidence interval, 1.06 to 3.69) and ln copeptin on day 4 with odds ratio 2.39 (95% confidence interval, 1.24 to 4.62) remained significant. Conclusion Our data demonstrate that copeptin levels increase progressively with the severity of sepsis and are independent predictors of mortality in VAP.application/pdfengCritical Care. London : Current Science, 2008. Vol. 12, n.1 (Feb. 2008), R11Pneumonia associada à ventilação mecânicaCopeptin, a novel prognostic biomarker in ventilator-associated pneumoniaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000655073.pdf000655073.pdfTexto completoapplication/pdf337390http://www.lume.ufrgs.br/bitstream/10183/21550/1/000655073.pdf2f07056ea0a3a294147e15824032fa2eMD51TEXT000655073.pdf.txt000655073.pdf.txtExtracted Texttext/plain33573http://www.lume.ufrgs.br/bitstream/10183/21550/2/000655073.pdf.txt59a3dd37b0b69a8578c94c305e8ed3a1MD52THUMBNAIL000655073.pdf.jpg000655073.pdf.jpgGenerated Thumbnailimage/jpeg2144http://www.lume.ufrgs.br/bitstream/10183/21550/3/000655073.pdf.jpgdafdcf329ac8ab728841c02394257d75MD5310183/215502018-10-17 09:40:20.167oai:www.lume.ufrgs.br:10183/21550Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-17T12:40:20Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
title Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
spellingShingle Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
Seligman, Renato
Pneumonia associada à ventilação mecânica
title_short Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
title_full Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
title_fullStr Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
title_full_unstemmed Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
title_sort Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia
author Seligman, Renato
author_facet Seligman, Renato
Papassotiriou, Jana
Morgenthaler, Nils G.
Meisner, Michael
Teixeira, Paulo Jose Zimermann
author_role author
author2 Papassotiriou, Jana
Morgenthaler, Nils G.
Meisner, Michael
Teixeira, Paulo Jose Zimermann
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Seligman, Renato
Papassotiriou, Jana
Morgenthaler, Nils G.
Meisner, Michael
Teixeira, Paulo Jose Zimermann
dc.subject.por.fl_str_mv Pneumonia associada à ventilação mecânica
topic Pneumonia associada à ventilação mecânica
description Background The present study sought to investigate the correlation of copeptin with the severity of septic status in patients with ventilator-associated pneumonia (VAP), and to analyze the usefulness of copeptin as a predictor of mortality in VAP. Methods The prospective observational cohort study was conducted in a teaching hospital. The subjects were 71 patients consecutively admitted to the intensive care unit from October 2003 to August 2005 who developed VAP. Copeptin levels were determined on day 0 and day 4 of VAP. Patients were followed for 28 days after the diagnosis, when they were considered survivors. Patients who died before day 28 were classified as nonsurvivors. There were no interventions. Results Copeptin levels increased from sepsis to severe sepsis and septic shock both on day 0 and day 4 (P = 0.001 and P = 0.009, respectively). Variables included in the univariable logistic regression analysis for mortality were age, gender, Acute Physiology and Chronic Health Evaluation II score and ln copeptin on day 0 and day 4. Mortality was directly related to ln copeptin levels on day 0 and day 4, with odds ratios of 2.32 (95% confidence interval, 1.25 to 4.29) and 2.31 (95% confidence interval, 1.25 to 4.25), respectively. In a multivariable logistic regression model for mortality, only ln copeptin on day 0 with odds ratio 1.97 (95% confidence interval, 1.06 to 3.69) and ln copeptin on day 4 with odds ratio 2.39 (95% confidence interval, 1.24 to 4.62) remained significant. Conclusion Our data demonstrate that copeptin levels increase progressively with the severity of sepsis and are independent predictors of mortality in VAP.
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dc.relation.ispartof.pt_BR.fl_str_mv Critical Care. London : Current Science, 2008. Vol. 12, n.1 (Feb. 2008), R11
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