Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/240347 |
Resumo: | Background: Bipolar disorder is associated with an increased burden of general medical conditions that might be related to a more severe illness course. Methods: This is a cross-sectional study that evaluated clinical correlates of general medical comorbidities in outpatients with bipolar disorder (BD) involving 203 adult patients with a DSM-IV diagnosis of BD, consecutively recruited from the Bipolar Research Program (PROTAHBI) in Porto Alegre, Brazil. Clinical, demographic and anthropometrical variables were systematically assessed, and general medical comorbidity was measured using the Cumulative Illness Rating Scale (CIRS). Results: The prevalence of one or more medical comorbidities was 90.1%. The most common were those from endocrine/metabolic/breast, neurologic and vascular categories. A high burden of general medical comorbidities (defined as CIRS total score ≥ 4) was related to increasing age and body mass index and longer duration of illness after controlling for confounding factors. Limitations: The cross-sectional design limits our ability to make causal conclusions. Also, our sample consisted of patients with longer illness duration from a tertiary clinic and may not generalize to the whole spectrum of bipolar disorder. Conclusions: BD was associated with a high burden of general medical conditions related to age, obesity and longer duration of illness. Medical comorbidities must be incorporated as a core feature in the development of effective treatment strategies for bipolar disorder. |
id |
UFRGS-2_a3db017b1e1ab623022d2da8311a25ab |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/240347 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Gomes, Fabiano AlvesMagalhães, Pedro Vieira da SilvaMagee, TaylorBrietzke, Elisa MacedoKunz, MaurícioKapczinski, Flávio Pereira2022-06-15T04:46:02Z20202666-9153http://hdl.handle.net/10183/240347001141148Background: Bipolar disorder is associated with an increased burden of general medical conditions that might be related to a more severe illness course. Methods: This is a cross-sectional study that evaluated clinical correlates of general medical comorbidities in outpatients with bipolar disorder (BD) involving 203 adult patients with a DSM-IV diagnosis of BD, consecutively recruited from the Bipolar Research Program (PROTAHBI) in Porto Alegre, Brazil. Clinical, demographic and anthropometrical variables were systematically assessed, and general medical comorbidity was measured using the Cumulative Illness Rating Scale (CIRS). Results: The prevalence of one or more medical comorbidities was 90.1%. The most common were those from endocrine/metabolic/breast, neurologic and vascular categories. A high burden of general medical comorbidities (defined as CIRS total score ≥ 4) was related to increasing age and body mass index and longer duration of illness after controlling for confounding factors. Limitations: The cross-sectional design limits our ability to make causal conclusions. Also, our sample consisted of patients with longer illness duration from a tertiary clinic and may not generalize to the whole spectrum of bipolar disorder. Conclusions: BD was associated with a high burden of general medical conditions related to age, obesity and longer duration of illness. Medical comorbidities must be incorporated as a core feature in the development of effective treatment strategies for bipolar disorder.application/pdfengJournal of affective disorders reports. [Amsterdam]. Vol. 1 (2020), 100001, 4 p.Transtorno bipolarComorbidadeBipolar disorderGeneral medical comorbidityCirsClinical correlates of high burden of general medical comorbidities in patients with bipolar disorderEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001141148.pdf.txt001141148.pdf.txtExtracted Texttext/plain21823http://www.lume.ufrgs.br/bitstream/10183/240347/2/001141148.pdf.txt916aa0ef4d8c3d3a74c457ef88f79b41MD52ORIGINAL001141148.pdfTexto completo (inglês)application/pdf400785http://www.lume.ufrgs.br/bitstream/10183/240347/1/001141148.pdfe931664a0847e822ae0046f38c544d52MD5110183/2403472022-06-16 04:43:28.257685oai:www.lume.ufrgs.br:10183/240347Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-06-16T07:43:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
title |
Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
spellingShingle |
Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder Gomes, Fabiano Alves Transtorno bipolar Comorbidade Bipolar disorder General medical comorbidity Cirs |
title_short |
Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
title_full |
Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
title_fullStr |
Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
title_full_unstemmed |
Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
title_sort |
Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
author |
Gomes, Fabiano Alves |
author_facet |
Gomes, Fabiano Alves Magalhães, Pedro Vieira da Silva Magee, Taylor Brietzke, Elisa Macedo Kunz, Maurício Kapczinski, Flávio Pereira |
author_role |
author |
author2 |
Magalhães, Pedro Vieira da Silva Magee, Taylor Brietzke, Elisa Macedo Kunz, Maurício Kapczinski, Flávio Pereira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Fabiano Alves Magalhães, Pedro Vieira da Silva Magee, Taylor Brietzke, Elisa Macedo Kunz, Maurício Kapczinski, Flávio Pereira |
dc.subject.por.fl_str_mv |
Transtorno bipolar Comorbidade |
topic |
Transtorno bipolar Comorbidade Bipolar disorder General medical comorbidity Cirs |
dc.subject.eng.fl_str_mv |
Bipolar disorder General medical comorbidity Cirs |
description |
Background: Bipolar disorder is associated with an increased burden of general medical conditions that might be related to a more severe illness course. Methods: This is a cross-sectional study that evaluated clinical correlates of general medical comorbidities in outpatients with bipolar disorder (BD) involving 203 adult patients with a DSM-IV diagnosis of BD, consecutively recruited from the Bipolar Research Program (PROTAHBI) in Porto Alegre, Brazil. Clinical, demographic and anthropometrical variables were systematically assessed, and general medical comorbidity was measured using the Cumulative Illness Rating Scale (CIRS). Results: The prevalence of one or more medical comorbidities was 90.1%. The most common were those from endocrine/metabolic/breast, neurologic and vascular categories. A high burden of general medical comorbidities (defined as CIRS total score ≥ 4) was related to increasing age and body mass index and longer duration of illness after controlling for confounding factors. Limitations: The cross-sectional design limits our ability to make causal conclusions. Also, our sample consisted of patients with longer illness duration from a tertiary clinic and may not generalize to the whole spectrum of bipolar disorder. Conclusions: BD was associated with a high burden of general medical conditions related to age, obesity and longer duration of illness. Medical comorbidities must be incorporated as a core feature in the development of effective treatment strategies for bipolar disorder. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2022-06-15T04:46:02Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/240347 |
dc.identifier.issn.pt_BR.fl_str_mv |
2666-9153 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001141148 |
identifier_str_mv |
2666-9153 001141148 |
url |
http://hdl.handle.net/10183/240347 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of affective disorders reports. [Amsterdam]. Vol. 1 (2020), 100001, 4 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/240347/2/001141148.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/240347/1/001141148.pdf |
bitstream.checksum.fl_str_mv |
916aa0ef4d8c3d3a74c457ef88f79b41 e931664a0847e822ae0046f38c544d52 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801225058785427456 |