Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/253608 |
Resumo: | Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical structures and their antibacterial activities. In addition, the low cost, ease of maintenance, and optimization-controlled fermentation conditions favor reproducibility in commercial scale. Given their importance, it is necessary to intensify the search for new molecules from endophytic microorganisms, and to increasingly invest in this very promising font. |
id |
UFRGS-2_a45b732c24e9c10bc0b6601e54623ab9 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/253608 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Silva, Dayse Pereira DiasCardoso, Macley SilvaMacedo, Alexandre José2023-01-12T04:56:33Z20222079-6382http://hdl.handle.net/10183/253608001157849Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical structures and their antibacterial activities. In addition, the low cost, ease of maintenance, and optimization-controlled fermentation conditions favor reproducibility in commercial scale. Given their importance, it is necessary to intensify the search for new molecules from endophytic microorganisms, and to increasingly invest in this very promising font.application/pdfengAntibiotics. Basel. Vol. 11, no. 11 (2022), 1509, 45 p.AntibacterianosBacterias gram-negativasInfecções bacterianasAntibacterial activityEndophytic fungiMetabolitesGram-negative bacteriaEndophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteriaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001157849.pdf.txt001157849.pdf.txtExtracted Texttext/plain301972http://www.lume.ufrgs.br/bitstream/10183/253608/2/001157849.pdf.txtb58367b22cedf66dad12d3485444da33MD52ORIGINAL001157849.pdfTexto completo (inglês)application/pdf53041969http://www.lume.ufrgs.br/bitstream/10183/253608/1/001157849.pdfd2c8da4cb606c94e079d169f504eb8e5MD5110183/2536082023-01-13 06:03:50.821193oai:www.lume.ufrgs.br:10183/253608Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2023-01-13T08:03:50Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria |
title |
Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria |
spellingShingle |
Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria Silva, Dayse Pereira Dias Antibacterianos Bacterias gram-negativas Infecções bacterianas Antibacterial activity Endophytic fungi Metabolites Gram-negative bacteria |
title_short |
Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria |
title_full |
Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria |
title_fullStr |
Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria |
title_full_unstemmed |
Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria |
title_sort |
Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria |
author |
Silva, Dayse Pereira Dias |
author_facet |
Silva, Dayse Pereira Dias Cardoso, Macley Silva Macedo, Alexandre José |
author_role |
author |
author2 |
Cardoso, Macley Silva Macedo, Alexandre José |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Silva, Dayse Pereira Dias Cardoso, Macley Silva Macedo, Alexandre José |
dc.subject.por.fl_str_mv |
Antibacterianos Bacterias gram-negativas Infecções bacterianas |
topic |
Antibacterianos Bacterias gram-negativas Infecções bacterianas Antibacterial activity Endophytic fungi Metabolites Gram-negative bacteria |
dc.subject.eng.fl_str_mv |
Antibacterial activity Endophytic fungi Metabolites Gram-negative bacteria |
description |
Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical structures and their antibacterial activities. In addition, the low cost, ease of maintenance, and optimization-controlled fermentation conditions favor reproducibility in commercial scale. Given their importance, it is necessary to intensify the search for new molecules from endophytic microorganisms, and to increasingly invest in this very promising font. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-01-12T04:56:33Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/253608 |
dc.identifier.issn.pt_BR.fl_str_mv |
2079-6382 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001157849 |
identifier_str_mv |
2079-6382 001157849 |
url |
http://hdl.handle.net/10183/253608 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Antibiotics. Basel. Vol. 11, no. 11 (2022), 1509, 45 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/253608/2/001157849.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/253608/1/001157849.pdf |
bitstream.checksum.fl_str_mv |
b58367b22cedf66dad12d3485444da33 d2c8da4cb606c94e079d169f504eb8e5 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
lume@ufrgs.br |
_version_ |
1817725154251243520 |