Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria

Detalhes bibliográficos
Autor(a) principal: Silva, Dayse Pereira Dias
Data de Publicação: 2022
Outros Autores: Cardoso, Macley Silva, Macedo, Alexandre José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/253608
Resumo: Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical structures and their antibacterial activities. In addition, the low cost, ease of maintenance, and optimization-controlled fermentation conditions favor reproducibility in commercial scale. Given their importance, it is necessary to intensify the search for new molecules from endophytic microorganisms, and to increasingly invest in this very promising font.
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spelling Silva, Dayse Pereira DiasCardoso, Macley SilvaMacedo, Alexandre José2023-01-12T04:56:33Z20222079-6382http://hdl.handle.net/10183/253608001157849Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical structures and their antibacterial activities. In addition, the low cost, ease of maintenance, and optimization-controlled fermentation conditions favor reproducibility in commercial scale. Given their importance, it is necessary to intensify the search for new molecules from endophytic microorganisms, and to increasingly invest in this very promising font.application/pdfengAntibiotics. Basel. Vol. 11, no. 11 (2022), 1509, 45 p.AntibacterianosBacterias gram-negativasInfecções bacterianasAntibacterial activityEndophytic fungiMetabolitesGram-negative bacteriaEndophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteriaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001157849.pdf.txt001157849.pdf.txtExtracted Texttext/plain301972http://www.lume.ufrgs.br/bitstream/10183/253608/2/001157849.pdf.txtb58367b22cedf66dad12d3485444da33MD52ORIGINAL001157849.pdfTexto completo (inglês)application/pdf53041969http://www.lume.ufrgs.br/bitstream/10183/253608/1/001157849.pdfd2c8da4cb606c94e079d169f504eb8e5MD5110183/2536082023-01-13 06:03:50.821193oai:www.lume.ufrgs.br:10183/253608Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2023-01-13T08:03:50Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
title Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
spellingShingle Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
Silva, Dayse Pereira Dias
Antibacterianos
Bacterias gram-negativas
Infecções bacterianas
Antibacterial activity
Endophytic fungi
Metabolites
Gram-negative bacteria
title_short Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
title_full Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
title_fullStr Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
title_full_unstemmed Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
title_sort Endophytic fungi as a source of antibacterial compounds : a focus on gram-negative bacteria
author Silva, Dayse Pereira Dias
author_facet Silva, Dayse Pereira Dias
Cardoso, Macley Silva
Macedo, Alexandre José
author_role author
author2 Cardoso, Macley Silva
Macedo, Alexandre José
author2_role author
author
dc.contributor.author.fl_str_mv Silva, Dayse Pereira Dias
Cardoso, Macley Silva
Macedo, Alexandre José
dc.subject.por.fl_str_mv Antibacterianos
Bacterias gram-negativas
Infecções bacterianas
topic Antibacterianos
Bacterias gram-negativas
Infecções bacterianas
Antibacterial activity
Endophytic fungi
Metabolites
Gram-negative bacteria
dc.subject.eng.fl_str_mv Antibacterial activity
Endophytic fungi
Metabolites
Gram-negative bacteria
description Bacterial resistance has become one of the main motives in the worldwide race for undescribed antibacterial agents. The difficulties in the treatment of bacterial infections are a public health issue that increasingly highlights the need for antimicrobial agents. Endophytic microorganisms are a promising alternative in the search for drugs, due to the vast number of metabolites produced with unique characteristics and bioactive potential. This review highlights the importance of endophytic microorganisms as a source of secondary metabolites in the search for active molecules against bacteria of medical importance, with a special focus on gram-negative species. This fact is supported by the findings raised in this review, which brings an arsenal of 166 molecules with characterized chemical structures and their antibacterial activities. In addition, the low cost, ease of maintenance, and optimization-controlled fermentation conditions favor reproducibility in commercial scale. Given their importance, it is necessary to intensify the search for new molecules from endophytic microorganisms, and to increasingly invest in this very promising font.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-12T04:56:33Z
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dc.relation.ispartof.pt_BR.fl_str_mv Antibiotics. Basel. Vol. 11, no. 11 (2022), 1509, 45 p.
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