Purinergic signaling in the modulation of redox biology

Detalhes bibliográficos
Autor(a) principal: Savio, Luiz Eduardo Baggio
Data de Publicação: 2021
Outros Autores: Aguiar, Raíssa Leite Tenorio, Alves, Vinícius Santos, Silva, Robson Coutinho, Wyse, Angela Terezinha de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/233752
Resumo: Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled receptors. The activation of these receptors triggers the production of reactive oxygen and nitrogen species and alters antioxidant defenses, modulating the redox biology of cells. The activation of P2 receptors is controlled by ecto-enzymes named ectonucleotidases, E-NTPDase1/CD39 and ecto-5’-nucleotidase/CD73) being the most relevant. The first enzyme hydrolyzes adenosine triphosphate (ATP) and adenosine diphosphate (ADP) into adenosine monophosphate (AMP), and the second catalyzes the hydrolysis of AMP to adenosine. The activity of these enzymes is diminished by oxidative stress. Adenosine actives P1 G-coupled receptors that, in general, promote the maintenance of redox hemostasis by decreasing reactive oxygen species (ROS) production and increase antioxidant enzymes. Intracellular purine metabolism can also contribute to ROS generation via xanthine oxidase activity, which converts hypoxanthine into xanthine, and finally, uric acid. In this review, we describe the mechanisms of redox biology modulated by purinergic signaling and how this signaling may be affected by disturbances in the redox homeostasis of cells.
id UFRGS-2_a4a34282aba45322f99d9ed9df39082f
oai_identifier_str oai:www.lume.ufrgs.br:10183/233752
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Savio, Luiz Eduardo BaggioAguiar, Raíssa Leite TenorioAlves, Vinícius SantosSilva, Robson CoutinhoWyse, Angela Terezinha de Souza2022-01-05T04:29:55Z20212213-2317http://hdl.handle.net/10183/233752001135026Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled receptors. The activation of these receptors triggers the production of reactive oxygen and nitrogen species and alters antioxidant defenses, modulating the redox biology of cells. The activation of P2 receptors is controlled by ecto-enzymes named ectonucleotidases, E-NTPDase1/CD39 and ecto-5’-nucleotidase/CD73) being the most relevant. The first enzyme hydrolyzes adenosine triphosphate (ATP) and adenosine diphosphate (ADP) into adenosine monophosphate (AMP), and the second catalyzes the hydrolysis of AMP to adenosine. The activity of these enzymes is diminished by oxidative stress. Adenosine actives P1 G-coupled receptors that, in general, promote the maintenance of redox hemostasis by decreasing reactive oxygen species (ROS) production and increase antioxidant enzymes. Intracellular purine metabolism can also contribute to ROS generation via xanthine oxidase activity, which converts hypoxanthine into xanthine, and finally, uric acid. In this review, we describe the mechanisms of redox biology modulated by purinergic signaling and how this signaling may be affected by disturbances in the redox homeostasis of cells.application/pdfengRedox biology. [Amsterdam]. Vol. 47 (Nov. 2021), 102137, 12 p.PurinérgicosReceptores purinérgicosEstresse oxidativoAdenosinaOxidative stressROSATPP2 receptorsEctonucleotidasesAdenosinePurinergic signaling in the modulation of redox biologyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001135026.pdf.txt001135026.pdf.txtExtracted Texttext/plain96877http://www.lume.ufrgs.br/bitstream/10183/233752/2/001135026.pdf.txtfd287b56d637f145b46f83b5f02666cdMD52ORIGINAL001135026.pdfTexto completo (inglês)application/pdf2836507http://www.lume.ufrgs.br/bitstream/10183/233752/1/001135026.pdff52fd9af0c99584eea96cb71cd8db84bMD5110183/2337522022-02-22 05:06:27.507973oai:www.lume.ufrgs.br:10183/233752Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-02-22T08:06:27Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Purinergic signaling in the modulation of redox biology
title Purinergic signaling in the modulation of redox biology
spellingShingle Purinergic signaling in the modulation of redox biology
Savio, Luiz Eduardo Baggio
Purinérgicos
Receptores purinérgicos
Estresse oxidativo
Adenosina
Oxidative stress
ROS
ATP
P2 receptors
Ectonucleotidases
Adenosine
title_short Purinergic signaling in the modulation of redox biology
title_full Purinergic signaling in the modulation of redox biology
title_fullStr Purinergic signaling in the modulation of redox biology
title_full_unstemmed Purinergic signaling in the modulation of redox biology
title_sort Purinergic signaling in the modulation of redox biology
author Savio, Luiz Eduardo Baggio
author_facet Savio, Luiz Eduardo Baggio
Aguiar, Raíssa Leite Tenorio
Alves, Vinícius Santos
Silva, Robson Coutinho
Wyse, Angela Terezinha de Souza
author_role author
author2 Aguiar, Raíssa Leite Tenorio
Alves, Vinícius Santos
Silva, Robson Coutinho
Wyse, Angela Terezinha de Souza
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Savio, Luiz Eduardo Baggio
Aguiar, Raíssa Leite Tenorio
Alves, Vinícius Santos
Silva, Robson Coutinho
Wyse, Angela Terezinha de Souza
dc.subject.por.fl_str_mv Purinérgicos
Receptores purinérgicos
Estresse oxidativo
Adenosina
topic Purinérgicos
Receptores purinérgicos
Estresse oxidativo
Adenosina
Oxidative stress
ROS
ATP
P2 receptors
Ectonucleotidases
Adenosine
dc.subject.eng.fl_str_mv Oxidative stress
ROS
ATP
P2 receptors
Ectonucleotidases
Adenosine
description Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled receptors. The activation of these receptors triggers the production of reactive oxygen and nitrogen species and alters antioxidant defenses, modulating the redox biology of cells. The activation of P2 receptors is controlled by ecto-enzymes named ectonucleotidases, E-NTPDase1/CD39 and ecto-5’-nucleotidase/CD73) being the most relevant. The first enzyme hydrolyzes adenosine triphosphate (ATP) and adenosine diphosphate (ADP) into adenosine monophosphate (AMP), and the second catalyzes the hydrolysis of AMP to adenosine. The activity of these enzymes is diminished by oxidative stress. Adenosine actives P1 G-coupled receptors that, in general, promote the maintenance of redox hemostasis by decreasing reactive oxygen species (ROS) production and increase antioxidant enzymes. Intracellular purine metabolism can also contribute to ROS generation via xanthine oxidase activity, which converts hypoxanthine into xanthine, and finally, uric acid. In this review, we describe the mechanisms of redox biology modulated by purinergic signaling and how this signaling may be affected by disturbances in the redox homeostasis of cells.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-01-05T04:29:55Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/233752
dc.identifier.issn.pt_BR.fl_str_mv 2213-2317
dc.identifier.nrb.pt_BR.fl_str_mv 001135026
identifier_str_mv 2213-2317
001135026
url http://hdl.handle.net/10183/233752
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Redox biology. [Amsterdam]. Vol. 47 (Nov. 2021), 102137, 12 p.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/233752/2/001135026.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/233752/1/001135026.pdf
bitstream.checksum.fl_str_mv fd287b56d637f145b46f83b5f02666cd
f52fd9af0c99584eea96cb71cd8db84b
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1815447779681501184