Purinergic signaling in the modulation of redox biology
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/233752 |
Resumo: | Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled receptors. The activation of these receptors triggers the production of reactive oxygen and nitrogen species and alters antioxidant defenses, modulating the redox biology of cells. The activation of P2 receptors is controlled by ecto-enzymes named ectonucleotidases, E-NTPDase1/CD39 and ecto-5’-nucleotidase/CD73) being the most relevant. The first enzyme hydrolyzes adenosine triphosphate (ATP) and adenosine diphosphate (ADP) into adenosine monophosphate (AMP), and the second catalyzes the hydrolysis of AMP to adenosine. The activity of these enzymes is diminished by oxidative stress. Adenosine actives P1 G-coupled receptors that, in general, promote the maintenance of redox hemostasis by decreasing reactive oxygen species (ROS) production and increase antioxidant enzymes. Intracellular purine metabolism can also contribute to ROS generation via xanthine oxidase activity, which converts hypoxanthine into xanthine, and finally, uric acid. In this review, we describe the mechanisms of redox biology modulated by purinergic signaling and how this signaling may be affected by disturbances in the redox homeostasis of cells. |
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Savio, Luiz Eduardo BaggioAguiar, Raíssa Leite TenorioAlves, Vinícius SantosSilva, Robson CoutinhoWyse, Angela Terezinha de Souza2022-01-05T04:29:55Z20212213-2317http://hdl.handle.net/10183/233752001135026Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled receptors. The activation of these receptors triggers the production of reactive oxygen and nitrogen species and alters antioxidant defenses, modulating the redox biology of cells. The activation of P2 receptors is controlled by ecto-enzymes named ectonucleotidases, E-NTPDase1/CD39 and ecto-5’-nucleotidase/CD73) being the most relevant. The first enzyme hydrolyzes adenosine triphosphate (ATP) and adenosine diphosphate (ADP) into adenosine monophosphate (AMP), and the second catalyzes the hydrolysis of AMP to adenosine. The activity of these enzymes is diminished by oxidative stress. Adenosine actives P1 G-coupled receptors that, in general, promote the maintenance of redox hemostasis by decreasing reactive oxygen species (ROS) production and increase antioxidant enzymes. Intracellular purine metabolism can also contribute to ROS generation via xanthine oxidase activity, which converts hypoxanthine into xanthine, and finally, uric acid. In this review, we describe the mechanisms of redox biology modulated by purinergic signaling and how this signaling may be affected by disturbances in the redox homeostasis of cells.application/pdfengRedox biology. [Amsterdam]. Vol. 47 (Nov. 2021), 102137, 12 p.PurinérgicosReceptores purinérgicosEstresse oxidativoAdenosinaOxidative stressROSATPP2 receptorsEctonucleotidasesAdenosinePurinergic signaling in the modulation of redox biologyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001135026.pdf.txt001135026.pdf.txtExtracted Texttext/plain96877http://www.lume.ufrgs.br/bitstream/10183/233752/2/001135026.pdf.txtfd287b56d637f145b46f83b5f02666cdMD52ORIGINAL001135026.pdfTexto completo (inglês)application/pdf2836507http://www.lume.ufrgs.br/bitstream/10183/233752/1/001135026.pdff52fd9af0c99584eea96cb71cd8db84bMD5110183/2337522022-02-22 05:06:27.507973oai:www.lume.ufrgs.br:10183/233752Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-02-22T08:06:27Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Purinergic signaling in the modulation of redox biology |
title |
Purinergic signaling in the modulation of redox biology |
spellingShingle |
Purinergic signaling in the modulation of redox biology Savio, Luiz Eduardo Baggio Purinérgicos Receptores purinérgicos Estresse oxidativo Adenosina Oxidative stress ROS ATP P2 receptors Ectonucleotidases Adenosine |
title_short |
Purinergic signaling in the modulation of redox biology |
title_full |
Purinergic signaling in the modulation of redox biology |
title_fullStr |
Purinergic signaling in the modulation of redox biology |
title_full_unstemmed |
Purinergic signaling in the modulation of redox biology |
title_sort |
Purinergic signaling in the modulation of redox biology |
author |
Savio, Luiz Eduardo Baggio |
author_facet |
Savio, Luiz Eduardo Baggio Aguiar, Raíssa Leite Tenorio Alves, Vinícius Santos Silva, Robson Coutinho Wyse, Angela Terezinha de Souza |
author_role |
author |
author2 |
Aguiar, Raíssa Leite Tenorio Alves, Vinícius Santos Silva, Robson Coutinho Wyse, Angela Terezinha de Souza |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Savio, Luiz Eduardo Baggio Aguiar, Raíssa Leite Tenorio Alves, Vinícius Santos Silva, Robson Coutinho Wyse, Angela Terezinha de Souza |
dc.subject.por.fl_str_mv |
Purinérgicos Receptores purinérgicos Estresse oxidativo Adenosina |
topic |
Purinérgicos Receptores purinérgicos Estresse oxidativo Adenosina Oxidative stress ROS ATP P2 receptors Ectonucleotidases Adenosine |
dc.subject.eng.fl_str_mv |
Oxidative stress ROS ATP P2 receptors Ectonucleotidases Adenosine |
description |
Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors): P2X ion channels and P2Y G protein-coupled receptors. The activation of these receptors triggers the production of reactive oxygen and nitrogen species and alters antioxidant defenses, modulating the redox biology of cells. The activation of P2 receptors is controlled by ecto-enzymes named ectonucleotidases, E-NTPDase1/CD39 and ecto-5’-nucleotidase/CD73) being the most relevant. The first enzyme hydrolyzes adenosine triphosphate (ATP) and adenosine diphosphate (ADP) into adenosine monophosphate (AMP), and the second catalyzes the hydrolysis of AMP to adenosine. The activity of these enzymes is diminished by oxidative stress. Adenosine actives P1 G-coupled receptors that, in general, promote the maintenance of redox hemostasis by decreasing reactive oxygen species (ROS) production and increase antioxidant enzymes. Intracellular purine metabolism can also contribute to ROS generation via xanthine oxidase activity, which converts hypoxanthine into xanthine, and finally, uric acid. In this review, we describe the mechanisms of redox biology modulated by purinergic signaling and how this signaling may be affected by disturbances in the redox homeostasis of cells. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-01-05T04:29:55Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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001135026 |
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http://hdl.handle.net/10183/233752 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Redox biology. [Amsterdam]. Vol. 47 (Nov. 2021), 102137, 12 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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