Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/250496 |
Resumo: | Background: We assessed the clinimetric properties of ataxia rating scales and functional tests, and made recommendations regarding their use. Methods: A systematic literature search was conducted to identify the instruments used to rate ataxia symptoms. The identified rating scales and functional ability tests were reviewed and ranked by the panel as "recommended," "suggested," or "listed" for the assessment of patients with discrete cerebellar disorders, using previously established criteria. Results: We reviewed 14 instruments (9 rating scales and 5 functional tests). "Recommended" rating scales for the assessment of symptoms severity were: for Friedreich's ataxia, the Friedreich's Ataxia Rating Scale, the International Cooperative Ataxia Rating Scale (ICARS), and the Scale for the Assessment and Rating of Ataxia (SARA); for spinocerebellar ataxias, ICARS and SARA; for ataxia telangiectasia: ICARS and SARA; for brain tumors, SARA; for congenital disorder of glycosylation-phosphomannomutase-2 deficiency, ICARS; for cerebellar symptoms in multiple sclerosis, ICARS; for cerebellar symptoms in multiple system atrophy: Unified Multiple System Atrophy Rating Scale and ICARS; and for fragile X-associated tremor ataxia syndrome, ICARS. "Recommended" functional tests were: for Friedreich's ataxia, Ataxia Functional Composite Score and Composite Cerebellar Functional Severity Score; and for spinocerebellar ataxias, Ataxia Functional Composite Score, Composite Cerebellar Functional Severity Score, and SCA Functional Index. Conclusions: We identified some "recommended" scales and functional tests for the assessment of patients with major hereditary ataxias and other cerebellar disorders. The main limitations of these instruments include the limited assessment of patients in the more severe end of the spectrum and children. Further research in these populations is warranted. |
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Perez-Lloret, SantiagoWarrenburg, Bart van deRossi, MalcoRodríguez-Blázquez, CarmenZesiewicz, TheresaSaute, Jonas Alex MoralesDürr, AlexandraNishizawa, MasatoyoMartinez-Martin, PabloStebbins, Glenn T.Schrag, AnetteSkorvanek , MatejMDS Rating Scales Review Committee2022-10-27T04:52:43Z20210885-3185http://hdl.handle.net/10183/250496001151973Background: We assessed the clinimetric properties of ataxia rating scales and functional tests, and made recommendations regarding their use. Methods: A systematic literature search was conducted to identify the instruments used to rate ataxia symptoms. The identified rating scales and functional ability tests were reviewed and ranked by the panel as "recommended," "suggested," or "listed" for the assessment of patients with discrete cerebellar disorders, using previously established criteria. Results: We reviewed 14 instruments (9 rating scales and 5 functional tests). "Recommended" rating scales for the assessment of symptoms severity were: for Friedreich's ataxia, the Friedreich's Ataxia Rating Scale, the International Cooperative Ataxia Rating Scale (ICARS), and the Scale for the Assessment and Rating of Ataxia (SARA); for spinocerebellar ataxias, ICARS and SARA; for ataxia telangiectasia: ICARS and SARA; for brain tumors, SARA; for congenital disorder of glycosylation-phosphomannomutase-2 deficiency, ICARS; for cerebellar symptoms in multiple sclerosis, ICARS; for cerebellar symptoms in multiple system atrophy: Unified Multiple System Atrophy Rating Scale and ICARS; and for fragile X-associated tremor ataxia syndrome, ICARS. "Recommended" functional tests were: for Friedreich's ataxia, Ataxia Functional Composite Score and Composite Cerebellar Functional Severity Score; and for spinocerebellar ataxias, Ataxia Functional Composite Score, Composite Cerebellar Functional Severity Score, and SCA Functional Index. Conclusions: We identified some "recommended" scales and functional tests for the assessment of patients with major hereditary ataxias and other cerebellar disorders. The main limitations of these instruments include the limited assessment of patients in the more severe end of the spectrum and children. Further research in these populations is warranted.application/pdfengMovement disorders. New York. Vol. 36, no. 2 (Feb. 2021), p. 283-297Ataxia de FriedreichDoenças cerebelaresAtaxias espinocerebelaresFriedreich's ataxiaAtaxiCerebellar disordersClinical trialsRating scalesSpinocerebellar ataxiaAssessment of ataxia rating scales and cerebellar functional tests : critique and recommendationsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001151973.pdf.txt001151973.pdf.txtExtracted Texttext/plain79050http://www.lume.ufrgs.br/bitstream/10183/250496/2/001151973.pdf.txt221f2afc7872ed65e8d15af0b1f652baMD52ORIGINAL001151973.pdfTexto completo (inglês)application/pdf319985http://www.lume.ufrgs.br/bitstream/10183/250496/1/001151973.pdf1fa4ad8e72a8f20842d1402855042adaMD5110183/2504962022-10-28 04:47:48.74401oai:www.lume.ufrgs.br:10183/250496Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-10-28T07:47:48Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations |
title |
Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations |
spellingShingle |
Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations Perez-Lloret, Santiago Ataxia de Friedreich Doenças cerebelares Ataxias espinocerebelares Friedreich's ataxia Ataxi Cerebellar disorders Clinical trials Rating scales Spinocerebellar ataxia |
title_short |
Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations |
title_full |
Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations |
title_fullStr |
Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations |
title_full_unstemmed |
Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations |
title_sort |
Assessment of ataxia rating scales and cerebellar functional tests : critique and recommendations |
author |
Perez-Lloret, Santiago |
author_facet |
Perez-Lloret, Santiago Warrenburg, Bart van de Rossi, Malco Rodríguez-Blázquez, Carmen Zesiewicz, Theresa Saute, Jonas Alex Morales Dürr, Alexandra Nishizawa, Masatoyo Martinez-Martin, Pablo Stebbins, Glenn T. Schrag, Anette Skorvanek , Matej MDS Rating Scales Review Committee |
author_role |
author |
author2 |
Warrenburg, Bart van de Rossi, Malco Rodríguez-Blázquez, Carmen Zesiewicz, Theresa Saute, Jonas Alex Morales Dürr, Alexandra Nishizawa, Masatoyo Martinez-Martin, Pablo Stebbins, Glenn T. Schrag, Anette Skorvanek , Matej MDS Rating Scales Review Committee |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Perez-Lloret, Santiago Warrenburg, Bart van de Rossi, Malco Rodríguez-Blázquez, Carmen Zesiewicz, Theresa Saute, Jonas Alex Morales Dürr, Alexandra Nishizawa, Masatoyo Martinez-Martin, Pablo Stebbins, Glenn T. Schrag, Anette Skorvanek , Matej MDS Rating Scales Review Committee |
dc.subject.por.fl_str_mv |
Ataxia de Friedreich Doenças cerebelares Ataxias espinocerebelares |
topic |
Ataxia de Friedreich Doenças cerebelares Ataxias espinocerebelares Friedreich's ataxia Ataxi Cerebellar disorders Clinical trials Rating scales Spinocerebellar ataxia |
dc.subject.eng.fl_str_mv |
Friedreich's ataxia Ataxi Cerebellar disorders Clinical trials Rating scales Spinocerebellar ataxia |
description |
Background: We assessed the clinimetric properties of ataxia rating scales and functional tests, and made recommendations regarding their use. Methods: A systematic literature search was conducted to identify the instruments used to rate ataxia symptoms. The identified rating scales and functional ability tests were reviewed and ranked by the panel as "recommended," "suggested," or "listed" for the assessment of patients with discrete cerebellar disorders, using previously established criteria. Results: We reviewed 14 instruments (9 rating scales and 5 functional tests). "Recommended" rating scales for the assessment of symptoms severity were: for Friedreich's ataxia, the Friedreich's Ataxia Rating Scale, the International Cooperative Ataxia Rating Scale (ICARS), and the Scale for the Assessment and Rating of Ataxia (SARA); for spinocerebellar ataxias, ICARS and SARA; for ataxia telangiectasia: ICARS and SARA; for brain tumors, SARA; for congenital disorder of glycosylation-phosphomannomutase-2 deficiency, ICARS; for cerebellar symptoms in multiple sclerosis, ICARS; for cerebellar symptoms in multiple system atrophy: Unified Multiple System Atrophy Rating Scale and ICARS; and for fragile X-associated tremor ataxia syndrome, ICARS. "Recommended" functional tests were: for Friedreich's ataxia, Ataxia Functional Composite Score and Composite Cerebellar Functional Severity Score; and for spinocerebellar ataxias, Ataxia Functional Composite Score, Composite Cerebellar Functional Severity Score, and SCA Functional Index. Conclusions: We identified some "recommended" scales and functional tests for the assessment of patients with major hereditary ataxias and other cerebellar disorders. The main limitations of these instruments include the limited assessment of patients in the more severe end of the spectrum and children. Further research in these populations is warranted. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-10-27T04:52:43Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/250496 |
dc.identifier.issn.pt_BR.fl_str_mv |
0885-3185 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001151973 |
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0885-3185 001151973 |
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http://hdl.handle.net/10183/250496 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Movement disorders. New York. Vol. 36, no. 2 (Feb. 2021), p. 283-297 |
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info:eu-repo/semantics/openAccess |
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