Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/200396 |
Resumo: | Purpose: To evaluate the concentration of transforming growth factor beta 1 (TGFB1) levels in a rat pleural effusion obtained by inoculation of intrapleural bacteria or turpentine through thoracentesis. Methods: Thirty-Nine Wistar rats were divided into three groups: Staphylococcus aureus (SA, n = 17); Streptococcus pneumoniae (SP, n = 12); and turpentine (control, n = 10). Pleural fluid was collected through ultrasound-guided thoracentesis 12 h, 24 h, and 36 h after instillation of bacteria or turpentine. Levels of TGFB1 were measured in pleural fluid. Results: At 12 h, mean TGFB1concentrations were 5.3450 pg/mL in the SA group, 5.3449 pg/mL in the SP group, and 5.3450 pg/mL in controls. At 24 h, they were 4.6700 pg/mL in the SA group, 4.6700 pg/mL in the SP group, and 4.6700 pg/mL in controls. At 36 h, they were 4.6699 pg/mL in the SA group and in control. No difference was observed among the groups in mean TGFB1concentration (p = 0.12); however, a significant intragroup reduction in mean TGFB1 was observed between 12 and 24 h (p < 0.01). Conclusion: The transforming growth factor beta 1 concentrations were not useful as a diagnostic tool or an early marker of infected pleural effusion. |
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Silva, Samanta Sarmento daPeterson, Guilherme EckertAmantea, Sergio LuisMiorelli, PatríciaUlbrich, Jane MariaRoesch, Eliane WurdigSanches, Paulo Roberto StefaniFraga, José Carlos Soares de2019-10-10T03:49:59Z20180102-8650http://hdl.handle.net/10183/200396001102639Purpose: To evaluate the concentration of transforming growth factor beta 1 (TGFB1) levels in a rat pleural effusion obtained by inoculation of intrapleural bacteria or turpentine through thoracentesis. Methods: Thirty-Nine Wistar rats were divided into three groups: Staphylococcus aureus (SA, n = 17); Streptococcus pneumoniae (SP, n = 12); and turpentine (control, n = 10). Pleural fluid was collected through ultrasound-guided thoracentesis 12 h, 24 h, and 36 h after instillation of bacteria or turpentine. Levels of TGFB1 were measured in pleural fluid. Results: At 12 h, mean TGFB1concentrations were 5.3450 pg/mL in the SA group, 5.3449 pg/mL in the SP group, and 5.3450 pg/mL in controls. At 24 h, they were 4.6700 pg/mL in the SA group, 4.6700 pg/mL in the SP group, and 4.6700 pg/mL in controls. At 36 h, they were 4.6699 pg/mL in the SA group and in control. No difference was observed among the groups in mean TGFB1concentration (p = 0.12); however, a significant intragroup reduction in mean TGFB1 was observed between 12 and 24 h (p < 0.01). Conclusion: The transforming growth factor beta 1 concentrations were not useful as a diagnostic tool or an early marker of infected pleural effusion.application/pdfengActa cirúrgica brasileira. Vol. 33, n. 2 (fev. 2018), p. 156-162Empiema pleuralCitocinasFator de crescimento transformador beta1Empyema, pleuralCytokinesTransforming growth factor beta 1RatsTransforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyemainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001102639.pdf.txt001102639.pdf.txtExtracted Texttext/plain21692http://www.lume.ufrgs.br/bitstream/10183/200396/2/001102639.pdf.txt482ce31849d744c8907825b1bfcc6c5fMD52ORIGINAL001102639.pdfTexto completo (inglês)application/pdf490159http://www.lume.ufrgs.br/bitstream/10183/200396/1/001102639.pdf7131e070d90b93f158179a31e4b356b7MD5110183/2003962022-11-18 05:55:48.805249oai:www.lume.ufrgs.br:10183/200396Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-11-18T07:55:48Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema |
title |
Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema |
spellingShingle |
Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema Silva, Samanta Sarmento da Empiema pleural Citocinas Fator de crescimento transformador beta1 Empyema, pleural Cytokines Transforming growth factor beta 1 Rats |
title_short |
Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema |
title_full |
Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema |
title_fullStr |
Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema |
title_full_unstemmed |
Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema |
title_sort |
Transforming growth factor beta1 (TGF-ß1) levels in a rat model of induced pleural empyema |
author |
Silva, Samanta Sarmento da |
author_facet |
Silva, Samanta Sarmento da Peterson, Guilherme Eckert Amantea, Sergio Luis Miorelli, Patrícia Ulbrich, Jane Maria Roesch, Eliane Wurdig Sanches, Paulo Roberto Stefani Fraga, José Carlos Soares de |
author_role |
author |
author2 |
Peterson, Guilherme Eckert Amantea, Sergio Luis Miorelli, Patrícia Ulbrich, Jane Maria Roesch, Eliane Wurdig Sanches, Paulo Roberto Stefani Fraga, José Carlos Soares de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Samanta Sarmento da Peterson, Guilherme Eckert Amantea, Sergio Luis Miorelli, Patrícia Ulbrich, Jane Maria Roesch, Eliane Wurdig Sanches, Paulo Roberto Stefani Fraga, José Carlos Soares de |
dc.subject.por.fl_str_mv |
Empiema pleural Citocinas Fator de crescimento transformador beta1 |
topic |
Empiema pleural Citocinas Fator de crescimento transformador beta1 Empyema, pleural Cytokines Transforming growth factor beta 1 Rats |
dc.subject.eng.fl_str_mv |
Empyema, pleural Cytokines Transforming growth factor beta 1 Rats |
description |
Purpose: To evaluate the concentration of transforming growth factor beta 1 (TGFB1) levels in a rat pleural effusion obtained by inoculation of intrapleural bacteria or turpentine through thoracentesis. Methods: Thirty-Nine Wistar rats were divided into three groups: Staphylococcus aureus (SA, n = 17); Streptococcus pneumoniae (SP, n = 12); and turpentine (control, n = 10). Pleural fluid was collected through ultrasound-guided thoracentesis 12 h, 24 h, and 36 h after instillation of bacteria or turpentine. Levels of TGFB1 were measured in pleural fluid. Results: At 12 h, mean TGFB1concentrations were 5.3450 pg/mL in the SA group, 5.3449 pg/mL in the SP group, and 5.3450 pg/mL in controls. At 24 h, they were 4.6700 pg/mL in the SA group, 4.6700 pg/mL in the SP group, and 4.6700 pg/mL in controls. At 36 h, they were 4.6699 pg/mL in the SA group and in control. No difference was observed among the groups in mean TGFB1concentration (p = 0.12); however, a significant intragroup reduction in mean TGFB1 was observed between 12 and 24 h (p < 0.01). Conclusion: The transforming growth factor beta 1 concentrations were not useful as a diagnostic tool or an early marker of infected pleural effusion. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-10-10T03:49:59Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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info:eu-repo/semantics/publishedVersion |
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publishedVersion |
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http://hdl.handle.net/10183/200396 |
dc.identifier.issn.pt_BR.fl_str_mv |
0102-8650 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001102639 |
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0102-8650 001102639 |
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http://hdl.handle.net/10183/200396 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Acta cirúrgica brasileira. Vol. 33, n. 2 (fev. 2018), p. 156-162 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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