High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)

Detalhes bibliográficos
Autor(a) principal: Garcia, Angelina
Data de Publicação: 2015
Outros Autores: Dermarchi, Dario A., Rodrigues, Luciana Tovo, Pauro, Maia, Callegari-Jacques, Sidia Maria, Salzano, Francisco Mauro, Hutz, Mara Helena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/129410
Resumo: The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.
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spelling Garcia, AngelinaDermarchi, Dario A.Rodrigues, Luciana TovoPauro, MaiaCallegari-Jacques, Sidia MariaSalzano, Francisco MauroHutz, Mara Helena2015-11-10T02:41:04Z20151415-4757http://hdl.handle.net/10183/129410000974458The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.application/pdfengGenetics and molecular biology. Ribeirão Preto, SP. Vol. 38, no. 3, (2015), p. 324-331Marcadores genéticosAncestralidadeArgentinaAIMsCórdobaSan LuisMigrationPopulation structureHigh interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000974458.pdf000974458.pdfTexto completo (inglês)application/pdf997175http://www.lume.ufrgs.br/bitstream/10183/129410/1/000974458.pdfbc158e77df7a32e86804d48972ebe792MD51TEXT000974458.pdf.txt000974458.pdf.txtExtracted Texttext/plain36826http://www.lume.ufrgs.br/bitstream/10183/129410/2/000974458.pdf.txta2f8e0a7f40262385997db56ed0a813aMD52THUMBNAIL000974458.pdf.jpg000974458.pdf.jpgGenerated Thumbnailimage/jpeg1819http://www.lume.ufrgs.br/bitstream/10183/129410/3/000974458.pdf.jpg028476303c5b6327e62b6c84738c5fb8MD5310183/1294102019-09-29 03:45:35.003178oai:www.lume.ufrgs.br:10183/129410Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-09-29T06:45:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
spellingShingle High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
Garcia, Angelina
Marcadores genéticos
Ancestralidade
Argentina
AIMs
Córdoba
San Luis
Migration
Population structure
title_short High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title_full High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title_fullStr High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title_full_unstemmed High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
title_sort High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)
author Garcia, Angelina
author_facet Garcia, Angelina
Dermarchi, Dario A.
Rodrigues, Luciana Tovo
Pauro, Maia
Callegari-Jacques, Sidia Maria
Salzano, Francisco Mauro
Hutz, Mara Helena
author_role author
author2 Dermarchi, Dario A.
Rodrigues, Luciana Tovo
Pauro, Maia
Callegari-Jacques, Sidia Maria
Salzano, Francisco Mauro
Hutz, Mara Helena
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Garcia, Angelina
Dermarchi, Dario A.
Rodrigues, Luciana Tovo
Pauro, Maia
Callegari-Jacques, Sidia Maria
Salzano, Francisco Mauro
Hutz, Mara Helena
dc.subject.por.fl_str_mv Marcadores genéticos
Ancestralidade
Argentina
topic Marcadores genéticos
Ancestralidade
Argentina
AIMs
Córdoba
San Luis
Migration
Population structure
dc.subject.eng.fl_str_mv AIMs
Córdoba
San Luis
Migration
Population structure
description The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-11-10T02:41:04Z
dc.date.issued.fl_str_mv 2015
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dc.relation.ispartof.pt_BR.fl_str_mv Genetics and molecular biology. Ribeirão Preto, SP. Vol. 38, no. 3, (2015), p. 324-331
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