Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/181629 |
Resumo: | Background: Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and pathological neurodevelopment This study investigated the relationship between SED, different domains of psychopathology, serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS) and brain-derived neurotrophic factor (BDNF). We hypothesized that a composite of socioeconomic risk would be associated with psychopathology and altered levels of peripheral biomarkers. In addition, we hypothesized that SED would moderate the associations between mental health problems, IL6, TBARS and BDNF. Methods and Findings: Using a cross-sectional design, we measured the serum levels of IL6, TBARS and BDNF in 495 children aged 6 to 12. We also investigated socio-demographic characteristics and mental health problems using the Child Behaviour Checklist (CBCL) DSM-oriented scales. SED was evaluated using a cumulative risk model. Generalized linear models were used to assess associations between SED, biomarkers levels and psychopathology. SED was significantly associated with serum levels of IL6 (RR = 1.026, 95% CI 1.004; 1.049, p = 0.020) and TBARS (RR = 1.077, 95% CI 1.028; 1.127, p = 0.002). The association between SED and BDNF was not statistically significant (RR = 1.031, 95% CI 0.997; 1.066, p = 0.077) SED was also significantly associated with all CBCL DSM-oriented scales (all p < 0.05), whereas serum biomarkers (i.e. IL6, TBARS, BDNF) were associated with specific subscales. Moreover, the associations between serum biomarkers and domains of psychopathology were moderated by SED, with stronger correlations between mental health problems, IL6, TBARS, and BDNF being observed in children with high SED. Conclusions In children, SED is highly associated with mental health problems. Our findings suggest that this association may be moderated via effects on multiple interacting neurobiological systems. |
id |
UFRGS-2_b2f0dafa4a35b828275f39c8c92a1ef4 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/181629 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Mansur, Rodrigo BarbachanKauer-Sant'Anna, MárciaRohde, Luis Augusto PaimBrietzke, Elisa Macedo2018-09-05T02:28:57Z20161932-6203http://hdl.handle.net/10183/181629001074013Background: Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and pathological neurodevelopment This study investigated the relationship between SED, different domains of psychopathology, serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS) and brain-derived neurotrophic factor (BDNF). We hypothesized that a composite of socioeconomic risk would be associated with psychopathology and altered levels of peripheral biomarkers. In addition, we hypothesized that SED would moderate the associations between mental health problems, IL6, TBARS and BDNF. Methods and Findings: Using a cross-sectional design, we measured the serum levels of IL6, TBARS and BDNF in 495 children aged 6 to 12. We also investigated socio-demographic characteristics and mental health problems using the Child Behaviour Checklist (CBCL) DSM-oriented scales. SED was evaluated using a cumulative risk model. Generalized linear models were used to assess associations between SED, biomarkers levels and psychopathology. SED was significantly associated with serum levels of IL6 (RR = 1.026, 95% CI 1.004; 1.049, p = 0.020) and TBARS (RR = 1.077, 95% CI 1.028; 1.127, p = 0.002). The association between SED and BDNF was not statistically significant (RR = 1.031, 95% CI 0.997; 1.066, p = 0.077) SED was also significantly associated with all CBCL DSM-oriented scales (all p < 0.05), whereas serum biomarkers (i.e. IL6, TBARS, BDNF) were associated with specific subscales. Moreover, the associations between serum biomarkers and domains of psychopathology were moderated by SED, with stronger correlations between mental health problems, IL6, TBARS, and BDNF being observed in children with high SED. Conclusions In children, SED is highly associated with mental health problems. Our findings suggest that this association may be moderated via effects on multiple interacting neurobiological systems.application/pdfengPLoS ONE. San Francisco. Vol. 11, no. 8 (Aug. 2016), e0160455, 14 p.Transtornos mentaisFator neurotrófico derivado do encéfaloSaúde mentalEstresse psicológicoBiomarcadoresSubstâncias reativas com ácido tiobarbitúricoInterleucina-6Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathologyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001074013.pdfTexto completo (inglês)application/pdf292839http://www.lume.ufrgs.br/bitstream/10183/181629/1/001074013.pdf7bd27ddad4ba7b520de91a01791aea9aMD51TEXT001074013.pdf.txt001074013.pdf.txtExtracted Texttext/plain55569http://www.lume.ufrgs.br/bitstream/10183/181629/2/001074013.pdf.txtc853cd6198ae0f798573eba6ff53cd6aMD52THUMBNAIL001074013.pdf.jpg001074013.pdf.jpgGenerated Thumbnailimage/jpeg2151http://www.lume.ufrgs.br/bitstream/10183/181629/3/001074013.pdf.jpgd3ef8625b7707441948bb27e89e21841MD5310183/1816292018-10-05 07:46:48.456oai:www.lume.ufrgs.br:10183/181629Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-05T10:46:48Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology |
title |
Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology |
spellingShingle |
Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology Mansur, Rodrigo Barbachan Transtornos mentais Fator neurotrófico derivado do encéfalo Saúde mental Estresse psicológico Biomarcadores Substâncias reativas com ácido tiobarbitúrico Interleucina-6 |
title_short |
Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology |
title_full |
Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology |
title_fullStr |
Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology |
title_full_unstemmed |
Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology |
title_sort |
Socioeconomic disadvantage moderates the association between peripheral biomarkers and childhood psychopathology |
author |
Mansur, Rodrigo Barbachan |
author_facet |
Mansur, Rodrigo Barbachan Kauer-Sant'Anna, Márcia Rohde, Luis Augusto Paim Brietzke, Elisa Macedo |
author_role |
author |
author2 |
Kauer-Sant'Anna, Márcia Rohde, Luis Augusto Paim Brietzke, Elisa Macedo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Mansur, Rodrigo Barbachan Kauer-Sant'Anna, Márcia Rohde, Luis Augusto Paim Brietzke, Elisa Macedo |
dc.subject.por.fl_str_mv |
Transtornos mentais Fator neurotrófico derivado do encéfalo Saúde mental Estresse psicológico Biomarcadores Substâncias reativas com ácido tiobarbitúrico Interleucina-6 |
topic |
Transtornos mentais Fator neurotrófico derivado do encéfalo Saúde mental Estresse psicológico Biomarcadores Substâncias reativas com ácido tiobarbitúrico Interleucina-6 |
description |
Background: Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and pathological neurodevelopment This study investigated the relationship between SED, different domains of psychopathology, serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS) and brain-derived neurotrophic factor (BDNF). We hypothesized that a composite of socioeconomic risk would be associated with psychopathology and altered levels of peripheral biomarkers. In addition, we hypothesized that SED would moderate the associations between mental health problems, IL6, TBARS and BDNF. Methods and Findings: Using a cross-sectional design, we measured the serum levels of IL6, TBARS and BDNF in 495 children aged 6 to 12. We also investigated socio-demographic characteristics and mental health problems using the Child Behaviour Checklist (CBCL) DSM-oriented scales. SED was evaluated using a cumulative risk model. Generalized linear models were used to assess associations between SED, biomarkers levels and psychopathology. SED was significantly associated with serum levels of IL6 (RR = 1.026, 95% CI 1.004; 1.049, p = 0.020) and TBARS (RR = 1.077, 95% CI 1.028; 1.127, p = 0.002). The association between SED and BDNF was not statistically significant (RR = 1.031, 95% CI 0.997; 1.066, p = 0.077) SED was also significantly associated with all CBCL DSM-oriented scales (all p < 0.05), whereas serum biomarkers (i.e. IL6, TBARS, BDNF) were associated with specific subscales. Moreover, the associations between serum biomarkers and domains of psychopathology were moderated by SED, with stronger correlations between mental health problems, IL6, TBARS, and BDNF being observed in children with high SED. Conclusions In children, SED is highly associated with mental health problems. Our findings suggest that this association may be moderated via effects on multiple interacting neurobiological systems. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2018-09-05T02:28:57Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/181629 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001074013 |
identifier_str_mv |
1932-6203 001074013 |
url |
http://hdl.handle.net/10183/181629 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS ONE. San Francisco. Vol. 11, no. 8 (Aug. 2016), e0160455, 14 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/181629/1/001074013.pdf http://www.lume.ufrgs.br/bitstream/10183/181629/2/001074013.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/181629/3/001074013.pdf.jpg |
bitstream.checksum.fl_str_mv |
7bd27ddad4ba7b520de91a01791aea9a c853cd6198ae0f798573eba6ff53cd6a d3ef8625b7707441948bb27e89e21841 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224949750300672 |