The effect of the carotenoid bixin and annatto seeds on hematological markers and nephrotoxicity in rats subjected to chronic treatment with cisplatin

• Autor(a) principal: Souza, Lucéia Fátima
• Data de Publicação: 2016
• Outros Autores: Pagno, Carlos Henrique, Medeiros, Niara da Silva, Barbosa, Sílvia, Santos, Paula Cilene Pereira dos, Rios, Alessandro de Oliveira, Elena, Matilde Achaval, Jong, Erna Vogt de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/275778
• topic: Bixina; Urucum; Cisplatin; Bixin; Annatto; Cell differentiation; Nephrotoxicity; Antioxidant

This study assessed the protective effect of the carotenoid bixin and annatto seeds against possible nephrotoxicity induced with a single peritoneal administration of pharmacological cisplatin in male Wistar rats. After 48 h, the blood cell differential count showed a significant reduction in neutrophil counts in rats that received a diet rich in bixin when compared to the group that received only cisplatin. The use of cisplatin led to an increase in kidney weight. The carotenoid bixin attenuated renal injury, characterized by increased polymorphonuclear infiltration. No protective effect was observed with respect to Annatto. These results demonstrate the role of toxic cisplatin and suggest that bixin affords a protective effect against cisplatin-induced nephrotoxicity in adult Wistar rats.