Cat's claw oxindole alkaloid isomerization induced by common extraction methods

Detalhes bibliográficos
Autor(a) principal: Kaiser, Samuel
Data de Publicação: 2013
Outros Autores: Verza, Simone Gasparin, Moraes, Renata Cougo, Resende, Pedro Ernesto de, Pavei, Cabral, Gonzales Ortega, George, Barreto, Fabiano
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/108895
Resumo: Cat’s claw oxindole alkaloids are prone to isomerization in aqueous solution. However, studies on their behavior in extraction processes are scarce. This paper addressed the issue by considering five commonly used extraction processes. Unlike dynamic maceration (DM) and ultrasound-assisted extraction, substantial isomerization was induced by static maceration, turbo-extraction and reflux extraction. After heating under reflux in DM, the kinetic order of isomerization was established and equations were fitted successfully using a four-parameter Weibull model (R2 > 0.999). Different isomerization rates and equilibrium constants were verified, revealing a possible matrix effect on alkaloid isomerization.
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spelling Kaiser, SamuelVerza, Simone GasparinMoraes, Renata CougoResende, Pedro Ernesto dePavei, CabralGonzales Ortega, GeorgeBarreto, Fabiano2015-01-13T02:14:45Z20130100-4042http://hdl.handle.net/10183/108895000915520Cat’s claw oxindole alkaloids are prone to isomerization in aqueous solution. However, studies on their behavior in extraction processes are scarce. This paper addressed the issue by considering five commonly used extraction processes. Unlike dynamic maceration (DM) and ultrasound-assisted extraction, substantial isomerization was induced by static maceration, turbo-extraction and reflux extraction. After heating under reflux in DM, the kinetic order of isomerization was established and equations were fitted successfully using a four-parameter Weibull model (R2 > 0.999). Different isomerization rates and equilibrium constants were verified, revealing a possible matrix effect on alkaloid isomerization.application/pdfporQuímica nova. São Paulo: Sociedade Brasileira de Química, 1978-. Vol. 36, n. 6, (2013), p. 808-814Unha de gatoUncaria tomentosaRubiaceaeIsomerizaçãoAlcalóidesCat’s clawIsomerization of oxindole alkaloidsExtraction methodsCat's claw oxindole alkaloid isomerization induced by common extraction methodsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000915520.pdf000915520.pdfTexto completo (inglês)application/pdf1185551http://www.lume.ufrgs.br/bitstream/10183/108895/1/000915520.pdfa36094feca381026bd134ab0507c313cMD51TEXT000915520.pdf.txt000915520.pdf.txtExtracted Texttext/plain39937http://www.lume.ufrgs.br/bitstream/10183/108895/2/000915520.pdf.txt979737a9e1366b1259777584955a9c37MD52THUMBNAIL000915520.pdf.jpg000915520.pdf.jpgGenerated Thumbnailimage/jpeg1880http://www.lume.ufrgs.br/bitstream/10183/108895/3/000915520.pdf.jpgefe1dff52e06e5543ab041042bd18860MD5310183/1088952018-10-23 08:38:06.078oai:www.lume.ufrgs.br:10183/108895Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-23T11:38:06Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Cat's claw oxindole alkaloid isomerization induced by common extraction methods
title Cat's claw oxindole alkaloid isomerization induced by common extraction methods
spellingShingle Cat's claw oxindole alkaloid isomerization induced by common extraction methods
Kaiser, Samuel
Unha de gato
Uncaria tomentosa
Rubiaceae
Isomerização
Alcalóides
Cat’s claw
Isomerization of oxindole alkaloids
Extraction methods
title_short Cat's claw oxindole alkaloid isomerization induced by common extraction methods
title_full Cat's claw oxindole alkaloid isomerization induced by common extraction methods
title_fullStr Cat's claw oxindole alkaloid isomerization induced by common extraction methods
title_full_unstemmed Cat's claw oxindole alkaloid isomerization induced by common extraction methods
title_sort Cat's claw oxindole alkaloid isomerization induced by common extraction methods
author Kaiser, Samuel
author_facet Kaiser, Samuel
Verza, Simone Gasparin
Moraes, Renata Cougo
Resende, Pedro Ernesto de
Pavei, Cabral
Gonzales Ortega, George
Barreto, Fabiano
author_role author
author2 Verza, Simone Gasparin
Moraes, Renata Cougo
Resende, Pedro Ernesto de
Pavei, Cabral
Gonzales Ortega, George
Barreto, Fabiano
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kaiser, Samuel
Verza, Simone Gasparin
Moraes, Renata Cougo
Resende, Pedro Ernesto de
Pavei, Cabral
Gonzales Ortega, George
Barreto, Fabiano
dc.subject.por.fl_str_mv Unha de gato
Uncaria tomentosa
Rubiaceae
Isomerização
Alcalóides
topic Unha de gato
Uncaria tomentosa
Rubiaceae
Isomerização
Alcalóides
Cat’s claw
Isomerization of oxindole alkaloids
Extraction methods
dc.subject.eng.fl_str_mv Cat’s claw
Isomerization of oxindole alkaloids
Extraction methods
description Cat’s claw oxindole alkaloids are prone to isomerization in aqueous solution. However, studies on their behavior in extraction processes are scarce. This paper addressed the issue by considering five commonly used extraction processes. Unlike dynamic maceration (DM) and ultrasound-assisted extraction, substantial isomerization was induced by static maceration, turbo-extraction and reflux extraction. After heating under reflux in DM, the kinetic order of isomerization was established and equations were fitted successfully using a four-parameter Weibull model (R2 > 0.999). Different isomerization rates and equilibrium constants were verified, revealing a possible matrix effect on alkaloid isomerization.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-01-13T02:14:45Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/108895
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.nrb.pt_BR.fl_str_mv 000915520
identifier_str_mv 0100-4042
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url http://hdl.handle.net/10183/108895
dc.language.iso.fl_str_mv por
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo: Sociedade Brasileira de Química, 1978-. Vol. 36, n. 6, (2013), p. 808-814
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