Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/238324 |
Resumo: | Research has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy. |
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Santos, Bernardo Gindri dosKlein, Caroline PeresCrestani, Mariana ScortegagnaMaurmann, Rafael MouraHözer, Régis MateusRodrigues, Karoline dos SantosAugust, Pauline MacielMatté, Cristiane2022-05-07T04:51:06Z20211660-4601http://hdl.handle.net/10183/238324001140294Research has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy.application/pdfengInternational journal of environmental research and public health. Basel. Vol. 18, no. 9 (May 2021), 4805, 20 p.Suplementos nutricionaisOxirreduçãoGravidezFlavonoidesFlavonoidsPregnancyDOHaDBrainRedox statusAntioxidantNaringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox statusEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001140294.pdf.txt001140294.pdf.txtExtracted Texttext/plain76496http://www.lume.ufrgs.br/bitstream/10183/238324/2/001140294.pdf.txt164a5b8434ecc6581754b1d18d7924f1MD52ORIGINAL001140294.pdfTexto completo (inglês)application/pdf1917524http://www.lume.ufrgs.br/bitstream/10183/238324/1/001140294.pdf8d39af9c938bf9fb0cfc47e1c98b81f4MD5110183/2383242022-05-08 04:48:07.449388oai:www.lume.ufrgs.br:10183/238324Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-05-08T07:48:07Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status |
title |
Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status |
spellingShingle |
Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status Santos, Bernardo Gindri dos Suplementos nutricionais Oxirredução Gravidez Flavonoides Flavonoids Pregnancy DOHaD Brain Redox status Antioxidant |
title_short |
Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status |
title_full |
Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status |
title_fullStr |
Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status |
title_full_unstemmed |
Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status |
title_sort |
Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status |
author |
Santos, Bernardo Gindri dos |
author_facet |
Santos, Bernardo Gindri dos Klein, Caroline Peres Crestani, Mariana Scortegagna Maurmann, Rafael Moura Hözer, Régis Mateus Rodrigues, Karoline dos Santos August, Pauline Maciel Matté, Cristiane |
author_role |
author |
author2 |
Klein, Caroline Peres Crestani, Mariana Scortegagna Maurmann, Rafael Moura Hözer, Régis Mateus Rodrigues, Karoline dos Santos August, Pauline Maciel Matté, Cristiane |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Bernardo Gindri dos Klein, Caroline Peres Crestani, Mariana Scortegagna Maurmann, Rafael Moura Hözer, Régis Mateus Rodrigues, Karoline dos Santos August, Pauline Maciel Matté, Cristiane |
dc.subject.por.fl_str_mv |
Suplementos nutricionais Oxirredução Gravidez Flavonoides |
topic |
Suplementos nutricionais Oxirredução Gravidez Flavonoides Flavonoids Pregnancy DOHaD Brain Redox status Antioxidant |
dc.subject.eng.fl_str_mv |
Flavonoids Pregnancy DOHaD Brain Redox status Antioxidant |
description |
Research has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-05-07T04:51:06Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/238324 |
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1660-4601 |
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001140294 |
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1660-4601 001140294 |
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http://hdl.handle.net/10183/238324 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International journal of environmental research and public health. Basel. Vol. 18, no. 9 (May 2021), 4805, 20 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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