Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status

Detalhes bibliográficos
Autor(a) principal: Santos, Bernardo Gindri dos
Data de Publicação: 2021
Outros Autores: Klein, Caroline Peres, Crestani, Mariana Scortegagna, Maurmann, Rafael Moura, Hözer, Régis Mateus, Rodrigues, Karoline dos Santos, August, Pauline Maciel, Matté, Cristiane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/238324
Resumo: Research has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy.
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spelling Santos, Bernardo Gindri dosKlein, Caroline PeresCrestani, Mariana ScortegagnaMaurmann, Rafael MouraHözer, Régis MateusRodrigues, Karoline dos SantosAugust, Pauline MacielMatté, Cristiane2022-05-07T04:51:06Z20211660-4601http://hdl.handle.net/10183/238324001140294Research has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy.application/pdfengInternational journal of environmental research and public health. Basel. Vol. 18, no. 9 (May 2021), 4805, 20 p.Suplementos nutricionaisOxirreduçãoGravidezFlavonoidesFlavonoidsPregnancyDOHaDBrainRedox statusAntioxidantNaringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox statusEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001140294.pdf.txt001140294.pdf.txtExtracted Texttext/plain76496http://www.lume.ufrgs.br/bitstream/10183/238324/2/001140294.pdf.txt164a5b8434ecc6581754b1d18d7924f1MD52ORIGINAL001140294.pdfTexto completo (inglês)application/pdf1917524http://www.lume.ufrgs.br/bitstream/10183/238324/1/001140294.pdf8d39af9c938bf9fb0cfc47e1c98b81f4MD5110183/2383242022-05-08 04:48:07.449388oai:www.lume.ufrgs.br:10183/238324Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-05-08T07:48:07Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
title Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
spellingShingle Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
Santos, Bernardo Gindri dos
Suplementos nutricionais
Oxirredução
Gravidez
Flavonoides
Flavonoids
Pregnancy
DOHaD
Brain
Redox status
Antioxidant
title_short Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
title_full Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
title_fullStr Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
title_full_unstemmed Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
title_sort Naringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox status
author Santos, Bernardo Gindri dos
author_facet Santos, Bernardo Gindri dos
Klein, Caroline Peres
Crestani, Mariana Scortegagna
Maurmann, Rafael Moura
Hözer, Régis Mateus
Rodrigues, Karoline dos Santos
August, Pauline Maciel
Matté, Cristiane
author_role author
author2 Klein, Caroline Peres
Crestani, Mariana Scortegagna
Maurmann, Rafael Moura
Hözer, Régis Mateus
Rodrigues, Karoline dos Santos
August, Pauline Maciel
Matté, Cristiane
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Bernardo Gindri dos
Klein, Caroline Peres
Crestani, Mariana Scortegagna
Maurmann, Rafael Moura
Hözer, Régis Mateus
Rodrigues, Karoline dos Santos
August, Pauline Maciel
Matté, Cristiane
dc.subject.por.fl_str_mv Suplementos nutricionais
Oxirredução
Gravidez
Flavonoides
topic Suplementos nutricionais
Oxirredução
Gravidez
Flavonoides
Flavonoids
Pregnancy
DOHaD
Brain
Redox status
Antioxidant
dc.subject.eng.fl_str_mv Flavonoids
Pregnancy
DOHaD
Brain
Redox status
Antioxidant
description Research has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-05-07T04:51:06Z
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv International journal of environmental research and public health. Basel. Vol. 18, no. 9 (May 2021), 4805, 20 p.
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