Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/87951 |
Resumo: | Genetic studies have long suggested the important role of theDRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes theNCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approaches. This study shows that behaviorally relevant SNPs from the NTAD cluster, such as rs1800497 (Taq1A) and rs6277, are ancient polymorphisms that date back to the common ancestor between modern humans and Neanderthals/Denisovans. Conserved synteny and neighborhood indicate the NTAD cluster seems to have been established at least 400 million years ago, when the first Sarcopterygians emerged. The NTAD genes are apparently co-regulated and this could be attributed to adaptive functional properties, including those that emerged when the central nervous system became more complex. Finally, our findings indicate that NTAD genes, which are related to neurogenesis and dopaminergic neurotransmission, should be approached as a unit in behavioral and psychiatric genetic studies. |
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Mota, Nina RothAraújo Júnior, Eli VieiraPaixão Côrtes, Vanessa RodriguesBortolini, Maria CátiraBau, Claiton Henrique Dotto2014-02-28T01:50:33Z20121415-4757http://hdl.handle.net/10183/87951000871430Genetic studies have long suggested the important role of theDRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes theNCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approaches. This study shows that behaviorally relevant SNPs from the NTAD cluster, such as rs1800497 (Taq1A) and rs6277, are ancient polymorphisms that date back to the common ancestor between modern humans and Neanderthals/Denisovans. Conserved synteny and neighborhood indicate the NTAD cluster seems to have been established at least 400 million years ago, when the first Sarcopterygians emerged. The NTAD genes are apparently co-regulated and this could be attributed to adaptive functional properties, including those that emerged when the central nervous system became more complex. Finally, our findings indicate that NTAD genes, which are related to neurogenesis and dopaminergic neurotransmission, should be approached as a unit in behavioral and psychiatric genetic studies.application/pdfengGenetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (2012), p. 912-918NeurotransmissoresDopaminaNeurogênesePsiquiatriaTranstornos mentaisNTAD clusterTaq1A SNPshared syntenyco-regulationpsychiatric geneticsLinking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene clusterinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000871430.pdf000871430.pdfTexto completo (inglês)application/pdf1302785http://www.lume.ufrgs.br/bitstream/10183/87951/1/000871430.pdfaa0020f36ba0c817f87b39929580b2d8MD51TEXT000871430.pdf.txt000871430.pdf.txtExtracted Texttext/plain43661http://www.lume.ufrgs.br/bitstream/10183/87951/2/000871430.pdf.txt9218a1b1f8ed08f6b36383564d736d7bMD52THUMBNAIL000871430.pdf.jpg000871430.pdf.jpgGenerated Thumbnailimage/jpeg1827http://www.lume.ufrgs.br/bitstream/10183/87951/3/000871430.pdf.jpgba5055078375770eafb5a990b2f788d9MD5310183/879512021-07-09 04:36:33.823341oai:www.lume.ufrgs.br:10183/87951Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-07-09T07:36:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster |
title |
Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster |
spellingShingle |
Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster Mota, Nina Roth Neurotransmissores Dopamina Neurogênese Psiquiatria Transtornos mentais NTAD cluster Taq1A SNP shared synteny co-regulation psychiatric genetics |
title_short |
Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster |
title_full |
Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster |
title_fullStr |
Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster |
title_full_unstemmed |
Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster |
title_sort |
Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster |
author |
Mota, Nina Roth |
author_facet |
Mota, Nina Roth Araújo Júnior, Eli Vieira Paixão Côrtes, Vanessa Rodrigues Bortolini, Maria Cátira Bau, Claiton Henrique Dotto |
author_role |
author |
author2 |
Araújo Júnior, Eli Vieira Paixão Côrtes, Vanessa Rodrigues Bortolini, Maria Cátira Bau, Claiton Henrique Dotto |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Mota, Nina Roth Araújo Júnior, Eli Vieira Paixão Côrtes, Vanessa Rodrigues Bortolini, Maria Cátira Bau, Claiton Henrique Dotto |
dc.subject.por.fl_str_mv |
Neurotransmissores Dopamina Neurogênese Psiquiatria Transtornos mentais |
topic |
Neurotransmissores Dopamina Neurogênese Psiquiatria Transtornos mentais NTAD cluster Taq1A SNP shared synteny co-regulation psychiatric genetics |
dc.subject.eng.fl_str_mv |
NTAD cluster Taq1A SNP shared synteny co-regulation psychiatric genetics |
description |
Genetic studies have long suggested the important role of theDRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes theNCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approaches. This study shows that behaviorally relevant SNPs from the NTAD cluster, such as rs1800497 (Taq1A) and rs6277, are ancient polymorphisms that date back to the common ancestor between modern humans and Neanderthals/Denisovans. Conserved synteny and neighborhood indicate the NTAD cluster seems to have been established at least 400 million years ago, when the first Sarcopterygians emerged. The NTAD genes are apparently co-regulated and this could be attributed to adaptive functional properties, including those that emerged when the central nervous system became more complex. Finally, our findings indicate that NTAD genes, which are related to neurogenesis and dopaminergic neurotransmission, should be approached as a unit in behavioral and psychiatric genetic studies. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2014-02-28T01:50:33Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/87951 |
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1415-4757 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000871430 |
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1415-4757 000871430 |
url |
http://hdl.handle.net/10183/87951 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (2012), p. 912-918 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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