Bombesin receptor regulation of emotional memory
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/194176 |
Resumo: | Mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide (GRP) act by activating NMB receptors (NMBR, BB1) and GRP receptors (GRPR, BB2), respectively. These two bombesin receptors are members of the G-protein-coupled receptor (GPCR) superfamily. In the brain, NMBR and GRPR are highly expressed in the brain areas involved in memory processing and emotional responses, such as the hippocampus and the amygdaloid nuclei. An increasing number of pharmacological and genetic studies in rodents indicate that NMBRs and GRPRs in brain regions including the dorsal hippocampus, the nucleus tractus solitarius, the basolateral amygdala, and cortical areas, regulate memory formation and expression, particularly for memories related to emotionally arousing tasks. GRPR signaling interacts with multiple protein kinase pathways as well as with other neurotransmitter, hormone, and growth factor systems in influencing memory formation. Together with evidence from human studies, the findings from rodent experiments suggest that bombesin receptors may be therapeutic targets in brain disorders involving memory dysfunction and anxiety. |
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Kent, PamelaSchroder, NadjaSchwartsmann, GilbertoRoesler, RafaelMerali, Zul2019-05-11T02:38:09Z20122191-0200http://hdl.handle.net/10183/194176000979873Mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide (GRP) act by activating NMB receptors (NMBR, BB1) and GRP receptors (GRPR, BB2), respectively. These two bombesin receptors are members of the G-protein-coupled receptor (GPCR) superfamily. In the brain, NMBR and GRPR are highly expressed in the brain areas involved in memory processing and emotional responses, such as the hippocampus and the amygdaloid nuclei. An increasing number of pharmacological and genetic studies in rodents indicate that NMBRs and GRPRs in brain regions including the dorsal hippocampus, the nucleus tractus solitarius, the basolateral amygdala, and cortical areas, regulate memory formation and expression, particularly for memories related to emotionally arousing tasks. GRPR signaling interacts with multiple protein kinase pathways as well as with other neurotransmitter, hormone, and growth factor systems in influencing memory formation. Together with evidence from human studies, the findings from rodent experiments suggest that bombesin receptors may be therapeutic targets in brain disorders involving memory dysfunction and anxiety.application/pdfengReviews in the neurosciences. Düsseldorf. Vol. 23, no. 5-6 (Nov. 2012), p. 571-586Receptores da bombesinaPeptídeo liberador de gastrinaMemóriaBB1 receptorNeuromedin B receptorMemory modulationGastrin releasing peptide receptorBB2 receptorBombesin receptor regulation of emotional memoryEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000979873.pdf.txt000979873.pdf.txtExtracted Texttext/plain81702http://www.lume.ufrgs.br/bitstream/10183/194176/2/000979873.pdf.txtf83cddbcebb7800d28f1250b4508bb40MD52ORIGINAL000979873.pdfTexto completo (inglês)application/pdf741434http://www.lume.ufrgs.br/bitstream/10183/194176/1/000979873.pdffcf19861441b4de4028708e2744443e0MD5110183/1941762019-05-12 02:36:12.694095oai:www.lume.ufrgs.br:10183/194176Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-05-12T05:36:12Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Bombesin receptor regulation of emotional memory |
title |
Bombesin receptor regulation of emotional memory |
spellingShingle |
Bombesin receptor regulation of emotional memory Kent, Pamela Receptores da bombesina Peptídeo liberador de gastrina Memória BB1 receptor Neuromedin B receptor Memory modulation Gastrin releasing peptide receptor BB2 receptor |
title_short |
Bombesin receptor regulation of emotional memory |
title_full |
Bombesin receptor regulation of emotional memory |
title_fullStr |
Bombesin receptor regulation of emotional memory |
title_full_unstemmed |
Bombesin receptor regulation of emotional memory |
title_sort |
Bombesin receptor regulation of emotional memory |
author |
Kent, Pamela |
author_facet |
Kent, Pamela Schroder, Nadja Schwartsmann, Gilberto Roesler, Rafael Merali, Zul |
author_role |
author |
author2 |
Schroder, Nadja Schwartsmann, Gilberto Roesler, Rafael Merali, Zul |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Kent, Pamela Schroder, Nadja Schwartsmann, Gilberto Roesler, Rafael Merali, Zul |
dc.subject.por.fl_str_mv |
Receptores da bombesina Peptídeo liberador de gastrina Memória |
topic |
Receptores da bombesina Peptídeo liberador de gastrina Memória BB1 receptor Neuromedin B receptor Memory modulation Gastrin releasing peptide receptor BB2 receptor |
dc.subject.eng.fl_str_mv |
BB1 receptor Neuromedin B receptor Memory modulation Gastrin releasing peptide receptor BB2 receptor |
description |
Mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide (GRP) act by activating NMB receptors (NMBR, BB1) and GRP receptors (GRPR, BB2), respectively. These two bombesin receptors are members of the G-protein-coupled receptor (GPCR) superfamily. In the brain, NMBR and GRPR are highly expressed in the brain areas involved in memory processing and emotional responses, such as the hippocampus and the amygdaloid nuclei. An increasing number of pharmacological and genetic studies in rodents indicate that NMBRs and GRPRs in brain regions including the dorsal hippocampus, the nucleus tractus solitarius, the basolateral amygdala, and cortical areas, regulate memory formation and expression, particularly for memories related to emotionally arousing tasks. GRPR signaling interacts with multiple protein kinase pathways as well as with other neurotransmitter, hormone, and growth factor systems in influencing memory formation. Together with evidence from human studies, the findings from rodent experiments suggest that bombesin receptors may be therapeutic targets in brain disorders involving memory dysfunction and anxiety. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2019-05-11T02:38:09Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/194176 |
dc.identifier.issn.pt_BR.fl_str_mv |
2191-0200 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000979873 |
identifier_str_mv |
2191-0200 000979873 |
url |
http://hdl.handle.net/10183/194176 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Reviews in the neurosciences. Düsseldorf. Vol. 23, no. 5-6 (Nov. 2012), p. 571-586 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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