Bombesin receptor regulation of emotional memory

Detalhes bibliográficos
Autor(a) principal: Kent, Pamela
Data de Publicação: 2012
Outros Autores: Schroder, Nadja, Schwartsmann, Gilberto, Roesler, Rafael, Merali, Zul
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/194176
Resumo: Mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide (GRP) act by activating NMB receptors (NMBR, BB1) and GRP receptors (GRPR, BB2), respectively. These two bombesin receptors are members of the G-protein-coupled receptor (GPCR) superfamily. In the brain, NMBR and GRPR are highly expressed in the brain areas involved in memory processing and emotional responses, such as the hippocampus and the amygdaloid nuclei. An increasing number of pharmacological and genetic studies in rodents indicate that NMBRs and GRPRs in brain regions including the dorsal hippocampus, the nucleus tractus solitarius, the basolateral amygdala, and cortical areas, regulate memory formation and expression, particularly for memories related to emotionally arousing tasks. GRPR signaling interacts with multiple protein kinase pathways as well as with other neurotransmitter, hormone, and growth factor systems in influencing memory formation. Together with evidence from human studies, the findings from rodent experiments suggest that bombesin receptors may be therapeutic targets in brain disorders involving memory dysfunction and anxiety.
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spelling Kent, PamelaSchroder, NadjaSchwartsmann, GilbertoRoesler, RafaelMerali, Zul2019-05-11T02:38:09Z20122191-0200http://hdl.handle.net/10183/194176000979873Mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide (GRP) act by activating NMB receptors (NMBR, BB1) and GRP receptors (GRPR, BB2), respectively. These two bombesin receptors are members of the G-protein-coupled receptor (GPCR) superfamily. In the brain, NMBR and GRPR are highly expressed in the brain areas involved in memory processing and emotional responses, such as the hippocampus and the amygdaloid nuclei. An increasing number of pharmacological and genetic studies in rodents indicate that NMBRs and GRPRs in brain regions including the dorsal hippocampus, the nucleus tractus solitarius, the basolateral amygdala, and cortical areas, regulate memory formation and expression, particularly for memories related to emotionally arousing tasks. GRPR signaling interacts with multiple protein kinase pathways as well as with other neurotransmitter, hormone, and growth factor systems in influencing memory formation. Together with evidence from human studies, the findings from rodent experiments suggest that bombesin receptors may be therapeutic targets in brain disorders involving memory dysfunction and anxiety.application/pdfengReviews in the neurosciences. Düsseldorf. Vol. 23, no. 5-6 (Nov. 2012), p. 571-586Receptores da bombesinaPeptídeo liberador de gastrinaMemóriaBB1 receptorNeuromedin B receptorMemory modulationGastrin releasing peptide receptorBB2 receptorBombesin receptor regulation of emotional memoryEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000979873.pdf.txt000979873.pdf.txtExtracted Texttext/plain81702http://www.lume.ufrgs.br/bitstream/10183/194176/2/000979873.pdf.txtf83cddbcebb7800d28f1250b4508bb40MD52ORIGINAL000979873.pdfTexto completo (inglês)application/pdf741434http://www.lume.ufrgs.br/bitstream/10183/194176/1/000979873.pdffcf19861441b4de4028708e2744443e0MD5110183/1941762019-05-12 02:36:12.694095oai:www.lume.ufrgs.br:10183/194176Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-05-12T05:36:12Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Bombesin receptor regulation of emotional memory
title Bombesin receptor regulation of emotional memory
spellingShingle Bombesin receptor regulation of emotional memory
Kent, Pamela
Receptores da bombesina
Peptídeo liberador de gastrina
Memória
BB1 receptor
Neuromedin B receptor
Memory modulation
Gastrin releasing peptide receptor
BB2 receptor
title_short Bombesin receptor regulation of emotional memory
title_full Bombesin receptor regulation of emotional memory
title_fullStr Bombesin receptor regulation of emotional memory
title_full_unstemmed Bombesin receptor regulation of emotional memory
title_sort Bombesin receptor regulation of emotional memory
author Kent, Pamela
author_facet Kent, Pamela
Schroder, Nadja
Schwartsmann, Gilberto
Roesler, Rafael
Merali, Zul
author_role author
author2 Schroder, Nadja
Schwartsmann, Gilberto
Roesler, Rafael
Merali, Zul
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Kent, Pamela
Schroder, Nadja
Schwartsmann, Gilberto
Roesler, Rafael
Merali, Zul
dc.subject.por.fl_str_mv Receptores da bombesina
Peptídeo liberador de gastrina
Memória
topic Receptores da bombesina
Peptídeo liberador de gastrina
Memória
BB1 receptor
Neuromedin B receptor
Memory modulation
Gastrin releasing peptide receptor
BB2 receptor
dc.subject.eng.fl_str_mv BB1 receptor
Neuromedin B receptor
Memory modulation
Gastrin releasing peptide receptor
BB2 receptor
description Mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide (GRP) act by activating NMB receptors (NMBR, BB1) and GRP receptors (GRPR, BB2), respectively. These two bombesin receptors are members of the G-protein-coupled receptor (GPCR) superfamily. In the brain, NMBR and GRPR are highly expressed in the brain areas involved in memory processing and emotional responses, such as the hippocampus and the amygdaloid nuclei. An increasing number of pharmacological and genetic studies in rodents indicate that NMBRs and GRPRs in brain regions including the dorsal hippocampus, the nucleus tractus solitarius, the basolateral amygdala, and cortical areas, regulate memory formation and expression, particularly for memories related to emotionally arousing tasks. GRPR signaling interacts with multiple protein kinase pathways as well as with other neurotransmitter, hormone, and growth factor systems in influencing memory formation. Together with evidence from human studies, the findings from rodent experiments suggest that bombesin receptors may be therapeutic targets in brain disorders involving memory dysfunction and anxiety.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-05-11T02:38:09Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/194176
dc.identifier.issn.pt_BR.fl_str_mv 2191-0200
dc.identifier.nrb.pt_BR.fl_str_mv 000979873
identifier_str_mv 2191-0200
000979873
url http://hdl.handle.net/10183/194176
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Reviews in the neurosciences. Düsseldorf. Vol. 23, no. 5-6 (Nov. 2012), p. 571-586
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