Impaired expression of NER gene network in sporadic solid tumors
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21537 |
Resumo: | Nucleotide repair genes are not generally altered in sporadic solid tumors. However, point mutations are found scattered throughout the genome of cancer cells indicating that the repair pathways are dysfunctional. To address this point, in this work we focus on the expression pathways rather than in the DNA structure of repair genes related to either genome stability or essential metabolic functions. We present here a novel statistical analysis comparing ten gene expression pathways in human normal and cancer cells using serial analysis of gene expression (SAGE) data. We find that in cancer cells nucleotide-excision repair (NER) and apoptosis are the most impaired pathways and have a highly altered diversity of gene expression profile when compared to normal cells. We propose that genome point mutations in sporadic tumors can be explained by a structurally conserved NER with a functional disorder generated from its entanglement with the apoptosis gene network. |
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Castro, Mauro Antônio AlvesMombach, Jose Carlos MerinoAlmeida, Rita Maria Cunha deMoreira, Jose Claudio Fonseca2010-05-05T04:15:44Z20070305-1048http://hdl.handle.net/10183/21537000603211Nucleotide repair genes are not generally altered in sporadic solid tumors. However, point mutations are found scattered throughout the genome of cancer cells indicating that the repair pathways are dysfunctional. To address this point, in this work we focus on the expression pathways rather than in the DNA structure of repair genes related to either genome stability or essential metabolic functions. We present here a novel statistical analysis comparing ten gene expression pathways in human normal and cancer cells using serial analysis of gene expression (SAGE) data. We find that in cancer cells nucleotide-excision repair (NER) and apoptosis are the most impaired pathways and have a highly altered diversity of gene expression profile when compared to normal cells. We propose that genome point mutations in sporadic tumors can be explained by a structurally conserved NER with a functional disorder generated from its entanglement with the apoptosis gene network.application/pdfengNucleic acids research. Oxford. Vol. 35, no. 6 (Mar. 2007), p. 1859-1867TumoresReparação do DNANucleotídeosGenéticaImpaired expression of NER gene network in sporadic solid tumorsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000603211.pdf000603211.pdfTexto completo (inglês)application/pdf205201http://www.lume.ufrgs.br/bitstream/10183/21537/1/000603211.pdf73caf55922710d964f6aae661a78b7c7MD51TEXT000603211.pdf.txt000603211.pdf.txtExtracted Texttext/plain40860http://www.lume.ufrgs.br/bitstream/10183/21537/2/000603211.pdf.txt83d39705f87c2312b113724340b6a613MD52THUMBNAIL000603211.pdf.jpg000603211.pdf.jpgGenerated Thumbnailimage/jpeg2175http://www.lume.ufrgs.br/bitstream/10183/21537/3/000603211.pdf.jpg82f7e91826422c26c2fc74de3e175dc7MD5310183/215372024-03-29 06:17:08.166985oai:www.lume.ufrgs.br:10183/21537Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-03-29T09:17:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Impaired expression of NER gene network in sporadic solid tumors |
title |
Impaired expression of NER gene network in sporadic solid tumors |
spellingShingle |
Impaired expression of NER gene network in sporadic solid tumors Castro, Mauro Antônio Alves Tumores Reparação do DNA Nucleotídeos Genética |
title_short |
Impaired expression of NER gene network in sporadic solid tumors |
title_full |
Impaired expression of NER gene network in sporadic solid tumors |
title_fullStr |
Impaired expression of NER gene network in sporadic solid tumors |
title_full_unstemmed |
Impaired expression of NER gene network in sporadic solid tumors |
title_sort |
Impaired expression of NER gene network in sporadic solid tumors |
author |
Castro, Mauro Antônio Alves |
author_facet |
Castro, Mauro Antônio Alves Mombach, Jose Carlos Merino Almeida, Rita Maria Cunha de Moreira, Jose Claudio Fonseca |
author_role |
author |
author2 |
Mombach, Jose Carlos Merino Almeida, Rita Maria Cunha de Moreira, Jose Claudio Fonseca |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Castro, Mauro Antônio Alves Mombach, Jose Carlos Merino Almeida, Rita Maria Cunha de Moreira, Jose Claudio Fonseca |
dc.subject.por.fl_str_mv |
Tumores Reparação do DNA Nucleotídeos Genética |
topic |
Tumores Reparação do DNA Nucleotídeos Genética |
description |
Nucleotide repair genes are not generally altered in sporadic solid tumors. However, point mutations are found scattered throughout the genome of cancer cells indicating that the repair pathways are dysfunctional. To address this point, in this work we focus on the expression pathways rather than in the DNA structure of repair genes related to either genome stability or essential metabolic functions. We present here a novel statistical analysis comparing ten gene expression pathways in human normal and cancer cells using serial analysis of gene expression (SAGE) data. We find that in cancer cells nucleotide-excision repair (NER) and apoptosis are the most impaired pathways and have a highly altered diversity of gene expression profile when compared to normal cells. We propose that genome point mutations in sporadic tumors can be explained by a structurally conserved NER with a functional disorder generated from its entanglement with the apoptosis gene network. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2010-05-05T04:15:44Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/21537 |
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0305-1048 |
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000603211 |
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0305-1048 000603211 |
url |
http://hdl.handle.net/10183/21537 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Nucleic acids research. Oxford. Vol. 35, no. 6 (Mar. 2007), p. 1859-1867 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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