Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/264184 |
Resumo: | Aim: to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus ondemand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods: An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized”. Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen “as needed,” at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results: The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion: Both regimens were effective in controlling postoperative pain after periodontal surgery. |
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Piardi, Carla CioatoVaz, Cristiane GalliFerreira, Maria Beatriz CardosoPilger, DiogoFernandes, Marilene IssaWeidlich, Patrícia2023-08-31T03:32:20Z20231677-3217http://hdl.handle.net/10183/264184001172506Aim: to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus ondemand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods: An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized”. Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen “as needed,” at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results: The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion: Both regimens were effective in controlling postoperative pain after periodontal surgery.application/pdfengBrazilian journal of oral sciences. Piracicaba (SP). Vol. 22 (2023), e238329, 14 p.AnalgésicosDor pós-operatóriaDoenças periodontaisAcetaminofenPain postoperativeRandomized controlled trials as topicPeriodontal diseasesAcetaminophenFixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trialinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001172506.pdf.txt001172506.pdf.txtExtracted Texttext/plain39192http://www.lume.ufrgs.br/bitstream/10183/264184/2/001172506.pdf.txtf95285b49ebd55a8d2b47285d9e0142aMD52ORIGINAL001172506.pdfTexto completo (inglês)application/pdf271938http://www.lume.ufrgs.br/bitstream/10183/264184/1/001172506.pdf9562d22f2de0dcab9aebf4042f886d22MD5110183/2641842023-09-01 03:31:34.425333oai:www.lume.ufrgs.br:10183/264184Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-01T06:31:34Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial |
title |
Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial |
spellingShingle |
Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial Piardi, Carla Cioato Analgésicos Dor pós-operatória Doenças periodontais Acetaminofen Pain postoperative Randomized controlled trials as topic Periodontal diseases Acetaminophen |
title_short |
Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial |
title_full |
Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial |
title_fullStr |
Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial |
title_full_unstemmed |
Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial |
title_sort |
Fixed and on-demand regimens of acetaminophen in periodontal surgery : randomized clinical trial |
author |
Piardi, Carla Cioato |
author_facet |
Piardi, Carla Cioato Vaz, Cristiane Galli Ferreira, Maria Beatriz Cardoso Pilger, Diogo Fernandes, Marilene Issa Weidlich, Patrícia |
author_role |
author |
author2 |
Vaz, Cristiane Galli Ferreira, Maria Beatriz Cardoso Pilger, Diogo Fernandes, Marilene Issa Weidlich, Patrícia |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Piardi, Carla Cioato Vaz, Cristiane Galli Ferreira, Maria Beatriz Cardoso Pilger, Diogo Fernandes, Marilene Issa Weidlich, Patrícia |
dc.subject.por.fl_str_mv |
Analgésicos Dor pós-operatória Doenças periodontais Acetaminofen |
topic |
Analgésicos Dor pós-operatória Doenças periodontais Acetaminofen Pain postoperative Randomized controlled trials as topic Periodontal diseases Acetaminophen |
dc.subject.eng.fl_str_mv |
Pain postoperative Randomized controlled trials as topic Periodontal diseases Acetaminophen |
description |
Aim: to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus ondemand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods: An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized”. Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen “as needed,” at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results: The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion: Both regimens were effective in controlling postoperative pain after periodontal surgery. |
publishDate |
2023 |
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2023-08-31T03:32:20Z |
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2023 |
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Brazilian journal of oral sciences. Piracicaba (SP). Vol. 22 (2023), e238329, 14 p. |
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