Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial

Detalhes bibliográficos
Autor(a) principal: Piardi, Carla Cioato
Data de Publicação: 2023
Outros Autores: Vaz, Cristiane Galli, Ferreira, Maria Beatriz Cardoso, Pilger, Diogo, Fernandes , Marilene Issa, Weidlich , Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian journal of oral sciences (Online)
Texto Completo: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668329
Resumo: Aim: to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus ondemand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods: An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized”. Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen “as needed,” at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results: The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion: Both regimens were effective in controlling postoperative pain after periodontal surgery.
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spelling Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trialPain, postoperativeRandomized controlled trials as topicPeriodontal diseasesAcetaminophenAim: to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus ondemand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods: An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized”. Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen “as needed,” at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results: The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion: Both regimens were effective in controlling postoperative pain after periodontal surgery.Universidade Estadual de Campinas2023-05-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/866832910.20396/bjos.v22i00.8668329Brazilian Journal of Oral Sciences; v. 22 (2023): Continuous Publication; e238329Brazilian Journal of Oral Sciences; Vol. 22 (2023): Continuous Publication; e2383291677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668329/31934Brazil; ContemporaryCopyright (c) 2022 Carla Cioato Piardi, Cristiane Galli Vaz, Maria Beatriz Cardoso Ferreira, Diogo Pilger, Marilene Issa Fernandes , Patrícia Weidlich https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPiardi, Carla CioatoVaz, Cristiane GalliFerreira, Maria Beatriz CardosoPilger, DiogoFernandes , Marilene IssaWeidlich , Patrícia2023-05-17T12:16:06Zoai:ojs.periodicos.sbu.unicamp.br:article/8668329Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2023-05-17T12:16:06Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false
dc.title.none.fl_str_mv Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial
title Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial
spellingShingle Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial
Piardi, Carla Cioato
Pain, postoperative
Randomized controlled trials as topic
Periodontal diseases
Acetaminophen
title_short Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial
title_full Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial
title_fullStr Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial
title_full_unstemmed Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial
title_sort Fixed and on-demand regimens of acetaminophen in periodontal surgery: randomized clinical trial
author Piardi, Carla Cioato
author_facet Piardi, Carla Cioato
Vaz, Cristiane Galli
Ferreira, Maria Beatriz Cardoso
Pilger, Diogo
Fernandes , Marilene Issa
Weidlich , Patrícia
author_role author
author2 Vaz, Cristiane Galli
Ferreira, Maria Beatriz Cardoso
Pilger, Diogo
Fernandes , Marilene Issa
Weidlich , Patrícia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Piardi, Carla Cioato
Vaz, Cristiane Galli
Ferreira, Maria Beatriz Cardoso
Pilger, Diogo
Fernandes , Marilene Issa
Weidlich , Patrícia
dc.subject.por.fl_str_mv Pain, postoperative
Randomized controlled trials as topic
Periodontal diseases
Acetaminophen
topic Pain, postoperative
Randomized controlled trials as topic
Periodontal diseases
Acetaminophen
description Aim: to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus ondemand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods: An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized”. Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen “as needed,” at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results: The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion: Both regimens were effective in controlling postoperative pain after periodontal surgery.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668329
10.20396/bjos.v22i00.8668329
url https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668329
identifier_str_mv 10.20396/bjos.v22i00.8668329
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668329/31934
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Brazil; Contemporary
dc.publisher.none.fl_str_mv Universidade Estadual de Campinas
publisher.none.fl_str_mv Universidade Estadual de Campinas
dc.source.none.fl_str_mv Brazilian Journal of Oral Sciences; v. 22 (2023): Continuous Publication; e238329
Brazilian Journal of Oral Sciences; Vol. 22 (2023): Continuous Publication; e238329
1677-3225
reponame:Brazilian journal of oral sciences (Online)
instname:Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
instname_str Universidade Estadual de Campinas (UNICAMP)
instacron_str UNICAMP
institution UNICAMP
reponame_str Brazilian journal of oral sciences (Online)
collection Brazilian journal of oral sciences (Online)
repository.name.fl_str_mv Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)
repository.mail.fl_str_mv brjorals@fop.unicamp.br||brjorals@fop.unicamp.br
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