Effect of aqueous extract of giant horsetail (equisetum giganteum l.) in antigen-induced arthritis

• Autor(a) principal: Farinon, Mirian
• Data de Publicação: 2013
• Outros Autores: Lora, Priscila Schmidt, Francescato, Leandro Nicolodi, Bassani, Valquiria Linck, Henriques, Amelia Teresinha, Xavier, Ricardo Machado, Oliveira, Patricia Gnieslaw de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/180802
• topic: Equisetum giganteum; Imunomodulacao; Artrite; Equisetum giganteum L.; Aqueous extract of giant horsetail (AEGH); Antigen-induced arthritis (AIA); Immunomodulatory therapy

Equisetum giganteum is a plant used in traditional medicine as diuretic. From our knowledge this is the first time this plant is tested in an in vivo model of acute inflammation. To evaluate the effect of aqueous extract of giant horsetail (AEGH) as immunomodulatory therapy, antigen-induced arthritis (AIA) was generated in mice with methylated bovine serum albumin (mBSA). Inflammation was evaluated by articular nociception, leukocytes migration and lymphocyte proliferation. AEGH reduced nociception at 3, 6 and 24 h (P < 0.01), decreased leukocyte migration (P < 0.015), and inhibited lymphocyte proliferation stimulated with Concanavalin A and Lipopolysaccharide (P < 0.05). In conclusion, AEGH has an anti-inflammatory potential in acute model of inflammation, as well as immunomodulatory effect on both B and T lymphocytes, with an action independent of cytotoxicity.