Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus

Detalhes bibliográficos
Autor(a) principal: Moehlecke, Milene
Data de Publicação: 2010
Outros Autores: Leitão, Cristiane Bauermann, Kramer, Caroline Kaercher, Rodrigues, Ticiana da Costa, Nickel, Célia, Silveiro, Sandra Pinho, Gross, Jorge Luiz, Canani, Luis Henrique Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/28263
Resumo: The objective of this study was to evaluate the effect of metabolic syndrome (MetS) and its individual components on the renal function of patients with type 2 diabetes mellitus (DM). A cross-sectional study was performed in 842 type 2 DM patients. A clinical and laboratory evaluation, including estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease formula, was performed. MetS was defined according to National Cholesterol Education Program - Adult Treatment Panel III criteria. Mean patient age was 57.9 ± 10.1 years and 313 (37.2%) patients were males. MetS was detected in 662 (78.6%) patients. A progressive reduction in eGFR was observed as the number of individual MetS components increased (one: 98.2 ± 30.8; two: 92.9 ± 28.1; three: 84.0 ± 25.1; four: 83.8 ± 28.5, and five: 79.0 ± 23.0; P < 0.001). MetS increased the risk for low eGFR (<60 mL·min-1·1.73 (m2)-1) 2.82-fold (95%CI = 1.55-5.12, P < 0.001). Hypertension (OR = 2.2, 95%CI = 1.39- 3.49, P = 0.001) and hypertriglyceridemia (OR = 1.62, 95%CI = 1.19-2.20, P = 0.002) were the individual components with the strongest associations with low eGFR. In conclusion, there is an association between MetS and the reduction of eGFR in patients with type 2 DM, with hypertension and hypertriglyceridemia being the most important contributors in this sample. Interventional studies should be conducted to determine if treatment of MetS can prevent renal failure in type 2 DM patients.
id UFRGS-2_d0ab7aaf93514c4c99431b0250d372ac
oai_identifier_str oai:www.lume.ufrgs.br:10183/28263
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Moehlecke, MileneLeitão, Cristiane BauermannKramer, Caroline KaercherRodrigues, Ticiana da CostaNickel, CéliaSilveiro, Sandra PinhoGross, Jorge LuizCanani, Luis Henrique Santos2011-03-26T06:01:37Z20100100-879Xhttp://hdl.handle.net/10183/28263000753410The objective of this study was to evaluate the effect of metabolic syndrome (MetS) and its individual components on the renal function of patients with type 2 diabetes mellitus (DM). A cross-sectional study was performed in 842 type 2 DM patients. A clinical and laboratory evaluation, including estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease formula, was performed. MetS was defined according to National Cholesterol Education Program - Adult Treatment Panel III criteria. Mean patient age was 57.9 ± 10.1 years and 313 (37.2%) patients were males. MetS was detected in 662 (78.6%) patients. A progressive reduction in eGFR was observed as the number of individual MetS components increased (one: 98.2 ± 30.8; two: 92.9 ± 28.1; three: 84.0 ± 25.1; four: 83.8 ± 28.5, and five: 79.0 ± 23.0; P < 0.001). MetS increased the risk for low eGFR (<60 mL·min-1·1.73 (m2)-1) 2.82-fold (95%CI = 1.55-5.12, P < 0.001). Hypertension (OR = 2.2, 95%CI = 1.39- 3.49, P = 0.001) and hypertriglyceridemia (OR = 1.62, 95%CI = 1.19-2.20, P = 0.002) were the individual components with the strongest associations with low eGFR. In conclusion, there is an association between MetS and the reduction of eGFR in patients with type 2 DM, with hypertension and hypertriglyceridemia being the most important contributors in this sample. Interventional studies should be conducted to determine if treatment of MetS can prevent renal failure in type 2 DM patients.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 43, n. 7 (jul. 2010), p. 687-693Síndrome metabólicaDiabetes mellitus tipo 2Taxa de filtração glomerularMetabolic syndromeType 2 diabetes mellitusGlomerular filtration rateModification of diet in renal diseaseEffect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitusinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000753410.pdf000753410.pdfTexto completo (inglês)application/pdf426219http://www.lume.ufrgs.br/bitstream/10183/28263/1/000753410.pdf4d7ca82a14ff6ac145a16e51a2427af0MD51TEXT000753410.pdf.txt000753410.pdf.txtExtracted Texttext/plain31480http://www.lume.ufrgs.br/bitstream/10183/28263/2/000753410.pdf.txt64604f368602dbca81a935146120c281MD52THUMBNAIL000753410.pdf.jpg000753410.pdf.jpgGenerated Thumbnailimage/jpeg2083http://www.lume.ufrgs.br/bitstream/10183/28263/3/000753410.pdf.jpgfeea0a2146c43ee7c2df22545adfae1bMD5310183/282632023-08-27 03:43:33.05293oai:www.lume.ufrgs.br:10183/28263Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-27T06:43:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
title Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
spellingShingle Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
Moehlecke, Milene
Síndrome metabólica
Diabetes mellitus tipo 2
Taxa de filtração glomerular
Metabolic syndrome
Type 2 diabetes mellitus
Glomerular filtration rate
Modification of diet in renal disease
title_short Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
title_full Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
title_fullStr Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
title_full_unstemmed Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
title_sort Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
author Moehlecke, Milene
author_facet Moehlecke, Milene
Leitão, Cristiane Bauermann
Kramer, Caroline Kaercher
Rodrigues, Ticiana da Costa
Nickel, Célia
Silveiro, Sandra Pinho
Gross, Jorge Luiz
Canani, Luis Henrique Santos
author_role author
author2 Leitão, Cristiane Bauermann
Kramer, Caroline Kaercher
Rodrigues, Ticiana da Costa
Nickel, Célia
Silveiro, Sandra Pinho
Gross, Jorge Luiz
Canani, Luis Henrique Santos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moehlecke, Milene
Leitão, Cristiane Bauermann
Kramer, Caroline Kaercher
Rodrigues, Ticiana da Costa
Nickel, Célia
Silveiro, Sandra Pinho
Gross, Jorge Luiz
Canani, Luis Henrique Santos
dc.subject.por.fl_str_mv Síndrome metabólica
Diabetes mellitus tipo 2
Taxa de filtração glomerular
topic Síndrome metabólica
Diabetes mellitus tipo 2
Taxa de filtração glomerular
Metabolic syndrome
Type 2 diabetes mellitus
Glomerular filtration rate
Modification of diet in renal disease
dc.subject.eng.fl_str_mv Metabolic syndrome
Type 2 diabetes mellitus
Glomerular filtration rate
Modification of diet in renal disease
description The objective of this study was to evaluate the effect of metabolic syndrome (MetS) and its individual components on the renal function of patients with type 2 diabetes mellitus (DM). A cross-sectional study was performed in 842 type 2 DM patients. A clinical and laboratory evaluation, including estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease formula, was performed. MetS was defined according to National Cholesterol Education Program - Adult Treatment Panel III criteria. Mean patient age was 57.9 ± 10.1 years and 313 (37.2%) patients were males. MetS was detected in 662 (78.6%) patients. A progressive reduction in eGFR was observed as the number of individual MetS components increased (one: 98.2 ± 30.8; two: 92.9 ± 28.1; three: 84.0 ± 25.1; four: 83.8 ± 28.5, and five: 79.0 ± 23.0; P < 0.001). MetS increased the risk for low eGFR (<60 mL·min-1·1.73 (m2)-1) 2.82-fold (95%CI = 1.55-5.12, P < 0.001). Hypertension (OR = 2.2, 95%CI = 1.39- 3.49, P = 0.001) and hypertriglyceridemia (OR = 1.62, 95%CI = 1.19-2.20, P = 0.002) were the individual components with the strongest associations with low eGFR. In conclusion, there is an association between MetS and the reduction of eGFR in patients with type 2 DM, with hypertension and hypertriglyceridemia being the most important contributors in this sample. Interventional studies should be conducted to determine if treatment of MetS can prevent renal failure in type 2 DM patients.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2011-03-26T06:01:37Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/other
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/28263
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.nrb.pt_BR.fl_str_mv 000753410
identifier_str_mv 0100-879X
000753410
url http://hdl.handle.net/10183/28263
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 43, n. 7 (jul. 2010), p. 687-693
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/28263/1/000753410.pdf
http://www.lume.ufrgs.br/bitstream/10183/28263/2/000753410.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/28263/3/000753410.pdf.jpg
bitstream.checksum.fl_str_mv 4d7ca82a14ff6ac145a16e51a2427af0
64604f368602dbca81a935146120c281
feea0a2146c43ee7c2df22545adfae1b
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1801224725243887616