Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/28263 |
Resumo: | The objective of this study was to evaluate the effect of metabolic syndrome (MetS) and its individual components on the renal function of patients with type 2 diabetes mellitus (DM). A cross-sectional study was performed in 842 type 2 DM patients. A clinical and laboratory evaluation, including estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease formula, was performed. MetS was defined according to National Cholesterol Education Program - Adult Treatment Panel III criteria. Mean patient age was 57.9 ± 10.1 years and 313 (37.2%) patients were males. MetS was detected in 662 (78.6%) patients. A progressive reduction in eGFR was observed as the number of individual MetS components increased (one: 98.2 ± 30.8; two: 92.9 ± 28.1; three: 84.0 ± 25.1; four: 83.8 ± 28.5, and five: 79.0 ± 23.0; P < 0.001). MetS increased the risk for low eGFR (<60 mL·min-1·1.73 (m2)-1) 2.82-fold (95%CI = 1.55-5.12, P < 0.001). Hypertension (OR = 2.2, 95%CI = 1.39- 3.49, P = 0.001) and hypertriglyceridemia (OR = 1.62, 95%CI = 1.19-2.20, P = 0.002) were the individual components with the strongest associations with low eGFR. In conclusion, there is an association between MetS and the reduction of eGFR in patients with type 2 DM, with hypertension and hypertriglyceridemia being the most important contributors in this sample. Interventional studies should be conducted to determine if treatment of MetS can prevent renal failure in type 2 DM patients. |
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Moehlecke, MileneLeitão, Cristiane BauermannKramer, Caroline KaercherRodrigues, Ticiana da CostaNickel, CéliaSilveiro, Sandra PinhoGross, Jorge LuizCanani, Luis Henrique Santos2011-03-26T06:01:37Z20100100-879Xhttp://hdl.handle.net/10183/28263000753410The objective of this study was to evaluate the effect of metabolic syndrome (MetS) and its individual components on the renal function of patients with type 2 diabetes mellitus (DM). A cross-sectional study was performed in 842 type 2 DM patients. A clinical and laboratory evaluation, including estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease formula, was performed. MetS was defined according to National Cholesterol Education Program - Adult Treatment Panel III criteria. Mean patient age was 57.9 ± 10.1 years and 313 (37.2%) patients were males. MetS was detected in 662 (78.6%) patients. A progressive reduction in eGFR was observed as the number of individual MetS components increased (one: 98.2 ± 30.8; two: 92.9 ± 28.1; three: 84.0 ± 25.1; four: 83.8 ± 28.5, and five: 79.0 ± 23.0; P < 0.001). MetS increased the risk for low eGFR (<60 mL·min-1·1.73 (m2)-1) 2.82-fold (95%CI = 1.55-5.12, P < 0.001). Hypertension (OR = 2.2, 95%CI = 1.39- 3.49, P = 0.001) and hypertriglyceridemia (OR = 1.62, 95%CI = 1.19-2.20, P = 0.002) were the individual components with the strongest associations with low eGFR. In conclusion, there is an association between MetS and the reduction of eGFR in patients with type 2 DM, with hypertension and hypertriglyceridemia being the most important contributors in this sample. Interventional studies should be conducted to determine if treatment of MetS can prevent renal failure in type 2 DM patients.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 43, n. 7 (jul. 2010), p. 687-693Síndrome metabólicaDiabetes mellitus tipo 2Taxa de filtração glomerularMetabolic syndromeType 2 diabetes mellitusGlomerular filtration rateModification of diet in renal diseaseEffect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitusinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000753410.pdf000753410.pdfTexto completo (inglês)application/pdf426219http://www.lume.ufrgs.br/bitstream/10183/28263/1/000753410.pdf4d7ca82a14ff6ac145a16e51a2427af0MD51TEXT000753410.pdf.txt000753410.pdf.txtExtracted Texttext/plain31480http://www.lume.ufrgs.br/bitstream/10183/28263/2/000753410.pdf.txt64604f368602dbca81a935146120c281MD52THUMBNAIL000753410.pdf.jpg000753410.pdf.jpgGenerated Thumbnailimage/jpeg2083http://www.lume.ufrgs.br/bitstream/10183/28263/3/000753410.pdf.jpgfeea0a2146c43ee7c2df22545adfae1bMD5310183/282632023-08-27 03:43:33.05293oai:www.lume.ufrgs.br:10183/28263Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-27T06:43:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus |
title |
Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus |
spellingShingle |
Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus Moehlecke, Milene Síndrome metabólica Diabetes mellitus tipo 2 Taxa de filtração glomerular Metabolic syndrome Type 2 diabetes mellitus Glomerular filtration rate Modification of diet in renal disease |
title_short |
Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus |
title_full |
Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus |
title_fullStr |
Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus |
title_full_unstemmed |
Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus |
title_sort |
Effect of metabolic syndrome and of its individual components on renal function of patients with type 2 diabetes mellitus |
author |
Moehlecke, Milene |
author_facet |
Moehlecke, Milene Leitão, Cristiane Bauermann Kramer, Caroline Kaercher Rodrigues, Ticiana da Costa Nickel, Célia Silveiro, Sandra Pinho Gross, Jorge Luiz Canani, Luis Henrique Santos |
author_role |
author |
author2 |
Leitão, Cristiane Bauermann Kramer, Caroline Kaercher Rodrigues, Ticiana da Costa Nickel, Célia Silveiro, Sandra Pinho Gross, Jorge Luiz Canani, Luis Henrique Santos |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Moehlecke, Milene Leitão, Cristiane Bauermann Kramer, Caroline Kaercher Rodrigues, Ticiana da Costa Nickel, Célia Silveiro, Sandra Pinho Gross, Jorge Luiz Canani, Luis Henrique Santos |
dc.subject.por.fl_str_mv |
Síndrome metabólica Diabetes mellitus tipo 2 Taxa de filtração glomerular |
topic |
Síndrome metabólica Diabetes mellitus tipo 2 Taxa de filtração glomerular Metabolic syndrome Type 2 diabetes mellitus Glomerular filtration rate Modification of diet in renal disease |
dc.subject.eng.fl_str_mv |
Metabolic syndrome Type 2 diabetes mellitus Glomerular filtration rate Modification of diet in renal disease |
description |
The objective of this study was to evaluate the effect of metabolic syndrome (MetS) and its individual components on the renal function of patients with type 2 diabetes mellitus (DM). A cross-sectional study was performed in 842 type 2 DM patients. A clinical and laboratory evaluation, including estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease formula, was performed. MetS was defined according to National Cholesterol Education Program - Adult Treatment Panel III criteria. Mean patient age was 57.9 ± 10.1 years and 313 (37.2%) patients were males. MetS was detected in 662 (78.6%) patients. A progressive reduction in eGFR was observed as the number of individual MetS components increased (one: 98.2 ± 30.8; two: 92.9 ± 28.1; three: 84.0 ± 25.1; four: 83.8 ± 28.5, and five: 79.0 ± 23.0; P < 0.001). MetS increased the risk for low eGFR (<60 mL·min-1·1.73 (m2)-1) 2.82-fold (95%CI = 1.55-5.12, P < 0.001). Hypertension (OR = 2.2, 95%CI = 1.39- 3.49, P = 0.001) and hypertriglyceridemia (OR = 1.62, 95%CI = 1.19-2.20, P = 0.002) were the individual components with the strongest associations with low eGFR. In conclusion, there is an association between MetS and the reduction of eGFR in patients with type 2 DM, with hypertension and hypertriglyceridemia being the most important contributors in this sample. Interventional studies should be conducted to determine if treatment of MetS can prevent renal failure in type 2 DM patients. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2011-03-26T06:01:37Z |
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http://hdl.handle.net/10183/28263 |
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0100-879X |
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000753410 |
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dc.language.iso.fl_str_mv |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 43, n. 7 (jul. 2010), p. 687-693 |
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