Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview

Detalhes bibliográficos
Autor(a) principal: Veras, Kleyton Santos
Data de Publicação: 2022
Outros Autores: Fachel, Flávia Nathiely Silveira, Bassani, Valquiria Linck, Teixeira, Helder Ferreira, Koester, Leticia Scherer
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/253630
Resumo: Hydroxycinnamic acids (HCAs) are a subclass of phenolic acids presenting caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA), and rosmarinic acid (RA) as the major representants, being broadly distributed into vegetal species and showing a range of biological potentials. Due to the low oral bioavailability of the HCAs, the development of delivery systems to promote better administration by the oral route is demanding. Among the systems, cyclodextrin (CD)-based delivery systems emerge as an important technology to solve this issue. Regarding these aspects, in this review, CD-based delivery systems containing HCAs are displayed, described, and discussed concerning the degree of interaction and their effects on crucial parameters that affect the oral bioavailability of HCAs.
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spelling Veras, Kleyton SantosFachel, Flávia Nathiely SilveiraBassani, Valquiria LinckTeixeira, Helder FerreiraKoester, Leticia Scherer2023-01-12T04:58:43Z20221999-4923http://hdl.handle.net/10183/253630001154563Hydroxycinnamic acids (HCAs) are a subclass of phenolic acids presenting caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA), and rosmarinic acid (RA) as the major representants, being broadly distributed into vegetal species and showing a range of biological potentials. Due to the low oral bioavailability of the HCAs, the development of delivery systems to promote better administration by the oral route is demanding. Among the systems, cyclodextrin (CD)-based delivery systems emerge as an important technology to solve this issue. Regarding these aspects, in this review, CD-based delivery systems containing HCAs are displayed, described, and discussed concerning the degree of interaction and their effects on crucial parameters that affect the oral bioavailability of HCAs.application/pdfengPharmaceutics. Basel. Vol. 14, n. 11 (2022), 2530, 25 p.Compostos fenólicosCiclodextrinasFarmáciaPhenolic acidsCyclodextrinsBinding constantCyclodextrin complexesAqueous solubilityStabilityCyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReviewEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001154563.pdf.txt001154563.pdf.txtExtracted Texttext/plain83944http://www.lume.ufrgs.br/bitstream/10183/253630/2/001154563.pdf.txtce3d3ccf74e6146e6b0ae5c071d2263eMD52ORIGINAL001154563.pdfTexto completo (inglês)application/pdf892385http://www.lume.ufrgs.br/bitstream/10183/253630/1/001154563.pdf627739d3ed42d473b2487c7263d503cbMD5110183/2536302023-01-13 06:04:24.737576oai:www.lume.ufrgs.br:10183/253630Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-01-13T08:04:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
title Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
spellingShingle Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
Veras, Kleyton Santos
Compostos fenólicos
Ciclodextrinas
Farmácia
Phenolic acids
Cyclodextrins
Binding constant
Cyclodextrin complexes
Aqueous solubility
Stability
title_short Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
title_full Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
title_fullStr Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
title_full_unstemmed Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
title_sort Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
author Veras, Kleyton Santos
author_facet Veras, Kleyton Santos
Fachel, Flávia Nathiely Silveira
Bassani, Valquiria Linck
Teixeira, Helder Ferreira
Koester, Leticia Scherer
author_role author
author2 Fachel, Flávia Nathiely Silveira
Bassani, Valquiria Linck
Teixeira, Helder Ferreira
Koester, Leticia Scherer
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Veras, Kleyton Santos
Fachel, Flávia Nathiely Silveira
Bassani, Valquiria Linck
Teixeira, Helder Ferreira
Koester, Leticia Scherer
dc.subject.por.fl_str_mv Compostos fenólicos
Ciclodextrinas
Farmácia
topic Compostos fenólicos
Ciclodextrinas
Farmácia
Phenolic acids
Cyclodextrins
Binding constant
Cyclodextrin complexes
Aqueous solubility
Stability
dc.subject.eng.fl_str_mv Phenolic acids
Cyclodextrins
Binding constant
Cyclodextrin complexes
Aqueous solubility
Stability
description Hydroxycinnamic acids (HCAs) are a subclass of phenolic acids presenting caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA), and rosmarinic acid (RA) as the major representants, being broadly distributed into vegetal species and showing a range of biological potentials. Due to the low oral bioavailability of the HCAs, the development of delivery systems to promote better administration by the oral route is demanding. Among the systems, cyclodextrin (CD)-based delivery systems emerge as an important technology to solve this issue. Regarding these aspects, in this review, CD-based delivery systems containing HCAs are displayed, described, and discussed concerning the degree of interaction and their effects on crucial parameters that affect the oral bioavailability of HCAs.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-12T04:58:43Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/253630
dc.identifier.issn.pt_BR.fl_str_mv 1999-4923
dc.identifier.nrb.pt_BR.fl_str_mv 001154563
identifier_str_mv 1999-4923
001154563
url http://hdl.handle.net/10183/253630
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Pharmaceutics. Basel. Vol. 14, n. 11 (2022), 2530, 25 p.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
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instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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