Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/253630 |
Resumo: | Hydroxycinnamic acids (HCAs) are a subclass of phenolic acids presenting caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA), and rosmarinic acid (RA) as the major representants, being broadly distributed into vegetal species and showing a range of biological potentials. Due to the low oral bioavailability of the HCAs, the development of delivery systems to promote better administration by the oral route is demanding. Among the systems, cyclodextrin (CD)-based delivery systems emerge as an important technology to solve this issue. Regarding these aspects, in this review, CD-based delivery systems containing HCAs are displayed, described, and discussed concerning the degree of interaction and their effects on crucial parameters that affect the oral bioavailability of HCAs. |
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Veras, Kleyton SantosFachel, Flávia Nathiely SilveiraBassani, Valquiria LinckTeixeira, Helder FerreiraKoester, Leticia Scherer2023-01-12T04:58:43Z20221999-4923http://hdl.handle.net/10183/253630001154563Hydroxycinnamic acids (HCAs) are a subclass of phenolic acids presenting caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA), and rosmarinic acid (RA) as the major representants, being broadly distributed into vegetal species and showing a range of biological potentials. Due to the low oral bioavailability of the HCAs, the development of delivery systems to promote better administration by the oral route is demanding. Among the systems, cyclodextrin (CD)-based delivery systems emerge as an important technology to solve this issue. Regarding these aspects, in this review, CD-based delivery systems containing HCAs are displayed, described, and discussed concerning the degree of interaction and their effects on crucial parameters that affect the oral bioavailability of HCAs.application/pdfengPharmaceutics. Basel. Vol. 14, n. 11 (2022), 2530, 25 p.Compostos fenólicosCiclodextrinasFarmáciaPhenolic acidsCyclodextrinsBinding constantCyclodextrin complexesAqueous solubilityStabilityCyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReviewEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001154563.pdf.txt001154563.pdf.txtExtracted Texttext/plain83944http://www.lume.ufrgs.br/bitstream/10183/253630/2/001154563.pdf.txtce3d3ccf74e6146e6b0ae5c071d2263eMD52ORIGINAL001154563.pdfTexto completo (inglês)application/pdf892385http://www.lume.ufrgs.br/bitstream/10183/253630/1/001154563.pdf627739d3ed42d473b2487c7263d503cbMD5110183/2536302023-01-13 06:04:24.737576oai:www.lume.ufrgs.br:10183/253630Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-01-13T08:04:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview |
title |
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview |
spellingShingle |
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview Veras, Kleyton Santos Compostos fenólicos Ciclodextrinas Farmácia Phenolic acids Cyclodextrins Binding constant Cyclodextrin complexes Aqueous solubility Stability |
title_short |
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview |
title_full |
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview |
title_fullStr |
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview |
title_full_unstemmed |
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview |
title_sort |
Cyclodextrin-based delivery systems and hydroxycinnamic acids : interactions and effects on crucial parameters influencing oral bioavailability — aReview |
author |
Veras, Kleyton Santos |
author_facet |
Veras, Kleyton Santos Fachel, Flávia Nathiely Silveira Bassani, Valquiria Linck Teixeira, Helder Ferreira Koester, Leticia Scherer |
author_role |
author |
author2 |
Fachel, Flávia Nathiely Silveira Bassani, Valquiria Linck Teixeira, Helder Ferreira Koester, Leticia Scherer |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Veras, Kleyton Santos Fachel, Flávia Nathiely Silveira Bassani, Valquiria Linck Teixeira, Helder Ferreira Koester, Leticia Scherer |
dc.subject.por.fl_str_mv |
Compostos fenólicos Ciclodextrinas Farmácia |
topic |
Compostos fenólicos Ciclodextrinas Farmácia Phenolic acids Cyclodextrins Binding constant Cyclodextrin complexes Aqueous solubility Stability |
dc.subject.eng.fl_str_mv |
Phenolic acids Cyclodextrins Binding constant Cyclodextrin complexes Aqueous solubility Stability |
description |
Hydroxycinnamic acids (HCAs) are a subclass of phenolic acids presenting caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA), and rosmarinic acid (RA) as the major representants, being broadly distributed into vegetal species and showing a range of biological potentials. Due to the low oral bioavailability of the HCAs, the development of delivery systems to promote better administration by the oral route is demanding. Among the systems, cyclodextrin (CD)-based delivery systems emerge as an important technology to solve this issue. Regarding these aspects, in this review, CD-based delivery systems containing HCAs are displayed, described, and discussed concerning the degree of interaction and their effects on crucial parameters that affect the oral bioavailability of HCAs. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-01-12T04:58:43Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/253630 |
dc.identifier.issn.pt_BR.fl_str_mv |
1999-4923 |
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001154563 |
identifier_str_mv |
1999-4923 001154563 |
url |
http://hdl.handle.net/10183/253630 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Pharmaceutics. Basel. Vol. 14, n. 11 (2022), 2530, 25 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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