The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/173369 |
Resumo: | Introduction: Caffeinated drinks are used for improve performance. Animal models represent investigational strategy that circumvents most of the drawbacks of research in humans, including motivational factors and the placebo effect. No animal model that could test whether different forms of administering caffeine affect exercise propensity was found in the literature. Methods: An animal model of grouped voluntary exercise was tested. Two-month-old male C57/bl mice were housed in a cage fitted with one running wheel and a monitoring system. Six animals per cage were introduced individually. To assess the sensitivity of the model, the effect of different caffeinated drinks was observed in mice exercising ad libitum. During 2 days, the mice received: 1) pure anhydrous caffeine 0.125 mg/mL (PC), 2) cola drink (CC), and 3) caffeine-taurine-glucuronolactone drink (CTG), intercalating wash-out periods of 2 days, receiving pure water. Results: The distance run during the periods of water ingestion was significantly lower than during the periods of stimulant drinks ingestion: PC (5.6 ± 1.3 km; p = 0.02), of CC ingestion (7.6 ± 0.6 km; p = 0.001), and of CTG ingestion (8.3 ± 1.6 km; p = 0.009). The performances when ingesting the three caffeinated drinks do not follow a dose-response curve. Conclusions: The model described here was able to measure the effect of caffeine intake on voluntary exercise of mice. The sensitivity of the model to the effect of caffeine needs to be further validated. The action of each component of the drinks on exercise performance needs to be clarified in future research. The present model is adequate for such investigation. |
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Silva, Roberto Pacheco daMartinez, DenisFiori, Cintia ZappeBueno, Kelly Silveira da SilvaUribe Ramos, Jhoana MercedesKaminski, Renata Schenkel RiveraFischer, Marcia KraideSilva, Leticia Maria TedescoGiordani, Juliana NevesBrendler, Juliana HeitichVieira, Juliana Langendorf da CostaDias, Yasmin de FreitasOliveira, Laura Martinewski dePiccin, Chaiane FaccoMartins, Emerson Ferreira2018-03-15T02:31:37Z20172357-9730http://hdl.handle.net/10183/173369001056642Introduction: Caffeinated drinks are used for improve performance. Animal models represent investigational strategy that circumvents most of the drawbacks of research in humans, including motivational factors and the placebo effect. No animal model that could test whether different forms of administering caffeine affect exercise propensity was found in the literature. Methods: An animal model of grouped voluntary exercise was tested. Two-month-old male C57/bl mice were housed in a cage fitted with one running wheel and a monitoring system. Six animals per cage were introduced individually. To assess the sensitivity of the model, the effect of different caffeinated drinks was observed in mice exercising ad libitum. During 2 days, the mice received: 1) pure anhydrous caffeine 0.125 mg/mL (PC), 2) cola drink (CC), and 3) caffeine-taurine-glucuronolactone drink (CTG), intercalating wash-out periods of 2 days, receiving pure water. Results: The distance run during the periods of water ingestion was significantly lower than during the periods of stimulant drinks ingestion: PC (5.6 ± 1.3 km; p = 0.02), of CC ingestion (7.6 ± 0.6 km; p = 0.001), and of CTG ingestion (8.3 ± 1.6 km; p = 0.009). The performances when ingesting the three caffeinated drinks do not follow a dose-response curve. Conclusions: The model described here was able to measure the effect of caffeine intake on voluntary exercise of mice. The sensitivity of the model to the effect of caffeine needs to be further validated. The action of each component of the drinks on exercise performance needs to be clarified in future research. The present model is adequate for such investigation.application/pdfengClinical and biomedical research. Porto Alegre. Vol. 37, n. 4 (2017), p. 316-322ExercícioCafeínaBebidas energéticasCorridaExerciseCaffeineEnergy drinksRunningThe effect of caffeine supplementation on exercise performance evaluated by a novel animal modelinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001056642.pdf001056642.pdfTexto completo (inglês)application/pdf1218397http://www.lume.ufrgs.br/bitstream/10183/173369/1/001056642.pdfb2acc256fe987516c7687b722d8b95ebMD51TEXT001056642.pdf.txt001056642.pdf.txtExtracted Texttext/plain26624http://www.lume.ufrgs.br/bitstream/10183/173369/2/001056642.pdf.txtd23033b69791a98ff9c230ad07a3625bMD5210183/1733692021-08-18 04:40:36.190786oai:www.lume.ufrgs.br:10183/173369Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-08-18T07:40:36Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The effect of caffeine supplementation on exercise performance evaluated by a novel animal model |
title |
The effect of caffeine supplementation on exercise performance evaluated by a novel animal model |
spellingShingle |
The effect of caffeine supplementation on exercise performance evaluated by a novel animal model Silva, Roberto Pacheco da Exercício Cafeína Bebidas energéticas Corrida Exercise Caffeine Energy drinks Running |
title_short |
The effect of caffeine supplementation on exercise performance evaluated by a novel animal model |
title_full |
The effect of caffeine supplementation on exercise performance evaluated by a novel animal model |
title_fullStr |
The effect of caffeine supplementation on exercise performance evaluated by a novel animal model |
title_full_unstemmed |
The effect of caffeine supplementation on exercise performance evaluated by a novel animal model |
title_sort |
The effect of caffeine supplementation on exercise performance evaluated by a novel animal model |
author |
Silva, Roberto Pacheco da |
author_facet |
Silva, Roberto Pacheco da Martinez, Denis Fiori, Cintia Zappe Bueno, Kelly Silveira da Silva Uribe Ramos, Jhoana Mercedes Kaminski, Renata Schenkel Rivera Fischer, Marcia Kraide Silva, Leticia Maria Tedesco Giordani, Juliana Neves Brendler, Juliana Heitich Vieira, Juliana Langendorf da Costa Dias, Yasmin de Freitas Oliveira, Laura Martinewski de Piccin, Chaiane Facco Martins, Emerson Ferreira |
author_role |
author |
author2 |
Martinez, Denis Fiori, Cintia Zappe Bueno, Kelly Silveira da Silva Uribe Ramos, Jhoana Mercedes Kaminski, Renata Schenkel Rivera Fischer, Marcia Kraide Silva, Leticia Maria Tedesco Giordani, Juliana Neves Brendler, Juliana Heitich Vieira, Juliana Langendorf da Costa Dias, Yasmin de Freitas Oliveira, Laura Martinewski de Piccin, Chaiane Facco Martins, Emerson Ferreira |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Roberto Pacheco da Martinez, Denis Fiori, Cintia Zappe Bueno, Kelly Silveira da Silva Uribe Ramos, Jhoana Mercedes Kaminski, Renata Schenkel Rivera Fischer, Marcia Kraide Silva, Leticia Maria Tedesco Giordani, Juliana Neves Brendler, Juliana Heitich Vieira, Juliana Langendorf da Costa Dias, Yasmin de Freitas Oliveira, Laura Martinewski de Piccin, Chaiane Facco Martins, Emerson Ferreira |
dc.subject.por.fl_str_mv |
Exercício Cafeína Bebidas energéticas Corrida |
topic |
Exercício Cafeína Bebidas energéticas Corrida Exercise Caffeine Energy drinks Running |
dc.subject.eng.fl_str_mv |
Exercise Caffeine Energy drinks Running |
description |
Introduction: Caffeinated drinks are used for improve performance. Animal models represent investigational strategy that circumvents most of the drawbacks of research in humans, including motivational factors and the placebo effect. No animal model that could test whether different forms of administering caffeine affect exercise propensity was found in the literature. Methods: An animal model of grouped voluntary exercise was tested. Two-month-old male C57/bl mice were housed in a cage fitted with one running wheel and a monitoring system. Six animals per cage were introduced individually. To assess the sensitivity of the model, the effect of different caffeinated drinks was observed in mice exercising ad libitum. During 2 days, the mice received: 1) pure anhydrous caffeine 0.125 mg/mL (PC), 2) cola drink (CC), and 3) caffeine-taurine-glucuronolactone drink (CTG), intercalating wash-out periods of 2 days, receiving pure water. Results: The distance run during the periods of water ingestion was significantly lower than during the periods of stimulant drinks ingestion: PC (5.6 ± 1.3 km; p = 0.02), of CC ingestion (7.6 ± 0.6 km; p = 0.001), and of CTG ingestion (8.3 ± 1.6 km; p = 0.009). The performances when ingesting the three caffeinated drinks do not follow a dose-response curve. Conclusions: The model described here was able to measure the effect of caffeine intake on voluntary exercise of mice. The sensitivity of the model to the effect of caffeine needs to be further validated. The action of each component of the drinks on exercise performance needs to be clarified in future research. The present model is adequate for such investigation. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2018-03-15T02:31:37Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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info:eu-repo/semantics/publishedVersion |
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publishedVersion |
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http://hdl.handle.net/10183/173369 |
dc.identifier.issn.pt_BR.fl_str_mv |
2357-9730 |
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001056642 |
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http://hdl.handle.net/10183/173369 |
dc.language.iso.fl_str_mv |
eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Clinical and biomedical research. Porto Alegre. Vol. 37, n. 4 (2017), p. 316-322 |
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openAccess |
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