The effect of caffeine supplementation on exercise performance evaluated by a novel animal model

Detalhes bibliográficos
Autor(a) principal: Silva, Roberto Pacheco da
Data de Publicação: 2017
Outros Autores: Martinez, Denis, Fiori, Cintia Zappe, Bueno, Kelly Silveira da Silva, Uribe Ramos, Jhoana Mercedes, Kaminski, Renata Schenkel Rivera, Fischer, Marcia Kraide, Silva, Leticia Maria Tedesco, Giordani, Juliana Neves, Brendler, Juliana Heitich, Vieira, Juliana Langendorf da Costa, Dias, Yasmin de Freitas, Oliveira, Laura Martinewski de, Piccin, Chaiane Facco, Martins, Emerson Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/173369
Resumo: Introduction: Caffeinated drinks are used for improve performance. Animal models represent investigational strategy that circumvents most of the drawbacks of research in humans, including motivational factors and the placebo effect. No animal model that could test whether different forms of administering caffeine affect exercise propensity was found in the literature. Methods: An animal model of grouped voluntary exercise was tested. Two-month-old male C57/bl mice were housed in a cage fitted with one running wheel and a monitoring system. Six animals per cage were introduced individually. To assess the sensitivity of the model, the effect of different caffeinated drinks was observed in mice exercising ad libitum. During 2 days, the mice received: 1) pure anhydrous caffeine 0.125 mg/mL (PC), 2) cola drink (CC), and 3) caffeine-taurine-glucuronolactone drink (CTG), intercalating wash-out periods of 2 days, receiving pure water. Results: The distance run during the periods of water ingestion was significantly lower than during the periods of stimulant drinks ingestion: PC (5.6 ± 1.3 km; p = 0.02), of CC ingestion (7.6 ± 0.6 km; p = 0.001), and of CTG ingestion (8.3 ± 1.6 km; p = 0.009). The performances when ingesting the three caffeinated drinks do not follow a dose-response curve. Conclusions: The model described here was able to measure the effect of caffeine intake on voluntary exercise of mice. The sensitivity of the model to the effect of caffeine needs to be further validated. The action of each component of the drinks on exercise performance needs to be clarified in future research. The present model is adequate for such investigation.
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spelling Silva, Roberto Pacheco daMartinez, DenisFiori, Cintia ZappeBueno, Kelly Silveira da SilvaUribe Ramos, Jhoana MercedesKaminski, Renata Schenkel RiveraFischer, Marcia KraideSilva, Leticia Maria TedescoGiordani, Juliana NevesBrendler, Juliana HeitichVieira, Juliana Langendorf da CostaDias, Yasmin de FreitasOliveira, Laura Martinewski dePiccin, Chaiane FaccoMartins, Emerson Ferreira2018-03-15T02:31:37Z20172357-9730http://hdl.handle.net/10183/173369001056642Introduction: Caffeinated drinks are used for improve performance. Animal models represent investigational strategy that circumvents most of the drawbacks of research in humans, including motivational factors and the placebo effect. No animal model that could test whether different forms of administering caffeine affect exercise propensity was found in the literature. Methods: An animal model of grouped voluntary exercise was tested. Two-month-old male C57/bl mice were housed in a cage fitted with one running wheel and a monitoring system. Six animals per cage were introduced individually. To assess the sensitivity of the model, the effect of different caffeinated drinks was observed in mice exercising ad libitum. During 2 days, the mice received: 1) pure anhydrous caffeine 0.125 mg/mL (PC), 2) cola drink (CC), and 3) caffeine-taurine-glucuronolactone drink (CTG), intercalating wash-out periods of 2 days, receiving pure water. Results: The distance run during the periods of water ingestion was significantly lower than during the periods of stimulant drinks ingestion: PC (5.6 ± 1.3 km; p = 0.02), of CC ingestion (7.6 ± 0.6 km; p = 0.001), and of CTG ingestion (8.3 ± 1.6 km; p = 0.009). The performances when ingesting the three caffeinated drinks do not follow a dose-response curve. Conclusions: The model described here was able to measure the effect of caffeine intake on voluntary exercise of mice. The sensitivity of the model to the effect of caffeine needs to be further validated. The action of each component of the drinks on exercise performance needs to be clarified in future research. The present model is adequate for such investigation.application/pdfengClinical and biomedical research. Porto Alegre. Vol. 37, n. 4 (2017), p. 316-322ExercícioCafeínaBebidas energéticasCorridaExerciseCaffeineEnergy drinksRunningThe effect of caffeine supplementation on exercise performance evaluated by a novel animal modelinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001056642.pdf001056642.pdfTexto completo (inglês)application/pdf1218397http://www.lume.ufrgs.br/bitstream/10183/173369/1/001056642.pdfb2acc256fe987516c7687b722d8b95ebMD51TEXT001056642.pdf.txt001056642.pdf.txtExtracted Texttext/plain26624http://www.lume.ufrgs.br/bitstream/10183/173369/2/001056642.pdf.txtd23033b69791a98ff9c230ad07a3625bMD5210183/1733692021-08-18 04:40:36.190786oai:www.lume.ufrgs.br:10183/173369Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-08-18T07:40:36Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
title The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
spellingShingle The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
Silva, Roberto Pacheco da
Exercício
Cafeína
Bebidas energéticas
Corrida
Exercise
Caffeine
Energy drinks
Running
title_short The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
title_full The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
title_fullStr The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
title_full_unstemmed The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
title_sort The effect of caffeine supplementation on exercise performance evaluated by a novel animal model
author Silva, Roberto Pacheco da
author_facet Silva, Roberto Pacheco da
Martinez, Denis
Fiori, Cintia Zappe
Bueno, Kelly Silveira da Silva
Uribe Ramos, Jhoana Mercedes
Kaminski, Renata Schenkel Rivera
Fischer, Marcia Kraide
Silva, Leticia Maria Tedesco
Giordani, Juliana Neves
Brendler, Juliana Heitich
Vieira, Juliana Langendorf da Costa
Dias, Yasmin de Freitas
Oliveira, Laura Martinewski de
Piccin, Chaiane Facco
Martins, Emerson Ferreira
author_role author
author2 Martinez, Denis
Fiori, Cintia Zappe
Bueno, Kelly Silveira da Silva
Uribe Ramos, Jhoana Mercedes
Kaminski, Renata Schenkel Rivera
Fischer, Marcia Kraide
Silva, Leticia Maria Tedesco
Giordani, Juliana Neves
Brendler, Juliana Heitich
Vieira, Juliana Langendorf da Costa
Dias, Yasmin de Freitas
Oliveira, Laura Martinewski de
Piccin, Chaiane Facco
Martins, Emerson Ferreira
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Roberto Pacheco da
Martinez, Denis
Fiori, Cintia Zappe
Bueno, Kelly Silveira da Silva
Uribe Ramos, Jhoana Mercedes
Kaminski, Renata Schenkel Rivera
Fischer, Marcia Kraide
Silva, Leticia Maria Tedesco
Giordani, Juliana Neves
Brendler, Juliana Heitich
Vieira, Juliana Langendorf da Costa
Dias, Yasmin de Freitas
Oliveira, Laura Martinewski de
Piccin, Chaiane Facco
Martins, Emerson Ferreira
dc.subject.por.fl_str_mv Exercício
Cafeína
Bebidas energéticas
Corrida
topic Exercício
Cafeína
Bebidas energéticas
Corrida
Exercise
Caffeine
Energy drinks
Running
dc.subject.eng.fl_str_mv Exercise
Caffeine
Energy drinks
Running
description Introduction: Caffeinated drinks are used for improve performance. Animal models represent investigational strategy that circumvents most of the drawbacks of research in humans, including motivational factors and the placebo effect. No animal model that could test whether different forms of administering caffeine affect exercise propensity was found in the literature. Methods: An animal model of grouped voluntary exercise was tested. Two-month-old male C57/bl mice were housed in a cage fitted with one running wheel and a monitoring system. Six animals per cage were introduced individually. To assess the sensitivity of the model, the effect of different caffeinated drinks was observed in mice exercising ad libitum. During 2 days, the mice received: 1) pure anhydrous caffeine 0.125 mg/mL (PC), 2) cola drink (CC), and 3) caffeine-taurine-glucuronolactone drink (CTG), intercalating wash-out periods of 2 days, receiving pure water. Results: The distance run during the periods of water ingestion was significantly lower than during the periods of stimulant drinks ingestion: PC (5.6 ± 1.3 km; p = 0.02), of CC ingestion (7.6 ± 0.6 km; p = 0.001), and of CTG ingestion (8.3 ± 1.6 km; p = 0.009). The performances when ingesting the three caffeinated drinks do not follow a dose-response curve. Conclusions: The model described here was able to measure the effect of caffeine intake on voluntary exercise of mice. The sensitivity of the model to the effect of caffeine needs to be further validated. The action of each component of the drinks on exercise performance needs to be clarified in future research. The present model is adequate for such investigation.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-15T02:31:37Z
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dc.identifier.issn.pt_BR.fl_str_mv 2357-9730
dc.identifier.nrb.pt_BR.fl_str_mv 001056642
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001056642
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Clinical and biomedical research. Porto Alegre. Vol. 37, n. 4 (2017), p. 316-322
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