Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/200537 |
Resumo: | Background: Longitudinal studies have consistently reported that prenatal exposure to acetaminophen can to lead to an increased risk of attention deficit-hyperactivity disorder during childhood. This study aimed to investigate the association between intrauterine exposure to acetaminophen and the presence of emotional and behavioral problems at the ages of 6 and 11 years in a low-middle income country. Methods: We performed a prospective longitudinal population-based study using data from the 2004 Pelotas birth cohort. From the 4231 initial cohort participants, 3722 and 3566 children were assessed at 6 and 11 years of age, respectively. The outcomes were assessed using the parent version of Strengths and Difficulties Questionnaire (SDQ). The cut-off points established for the Brazilian population were used to categorize the outcomes. Crude and adjusted odds ratio were obtained through logistic regression. Results: Acetaminophen was used by 27.5% (95% confidence interval [CI]: 26.1–28.9) of the mothers at least once during pregnancy. The prevalence of emotional problems at 6 and 11 years was 13.6 and 19.9%, respectively. For hyperactivity problems, prevalence was 13.9 and 16.1%, respectively. Intrauterine exposure to acetaminophen increased the odds of having emotional (odds ratio [OR] = 1.47; 95% CI: 1.07–2.02) and hyperactivity/inattention (OR = 1.42; 95% CI: 1.06–1.92) problems in 6-year-old boys. At the age of 11, a small decrease in the effect was observed for both outcomes after adjustment: OR = 1.31 (95% CI: 0.99–1.73) for emotional problems and OR = 1.25 (95% CI: 0.95–1.65) for hyperactivity/inattention in boys. No association for any phenotypes at both ages was observed for girls. Conclusion: The effect of intrauterine exposure to acetaminophen in emotional and hyperactivity symptoms was dependent on sex in a Brazilian cohort. While it seemed to be important for boys, mainly at 6 years of age, for girls, no association was observed. |
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Rodrigues, Luciana TovoSchneider, Bruna CelestinoSilva, Thais Martins daSilva, Bianca Del Ponte daLoret De Mola, ChristianFaccini, Lavinia SchulerVianna, Fernanda Sales LuizMunhoz, Tiago NeuenfeldEntiauspe, Ludmila GonçalvesSilveira, Mariângela Freitas daSantos, Iná da Silva dosMatijasevich, AliciaBarros, Aluisio Jardim Dornellas deRohde, Luis Augusto PaimBertoldi, Andréa Dâmaso2019-10-11T03:55:58Z20181471-244Xhttp://hdl.handle.net/10183/200537001100315Background: Longitudinal studies have consistently reported that prenatal exposure to acetaminophen can to lead to an increased risk of attention deficit-hyperactivity disorder during childhood. This study aimed to investigate the association between intrauterine exposure to acetaminophen and the presence of emotional and behavioral problems at the ages of 6 and 11 years in a low-middle income country. Methods: We performed a prospective longitudinal population-based study using data from the 2004 Pelotas birth cohort. From the 4231 initial cohort participants, 3722 and 3566 children were assessed at 6 and 11 years of age, respectively. The outcomes were assessed using the parent version of Strengths and Difficulties Questionnaire (SDQ). The cut-off points established for the Brazilian population were used to categorize the outcomes. Crude and adjusted odds ratio were obtained through logistic regression. Results: Acetaminophen was used by 27.5% (95% confidence interval [CI]: 26.1–28.9) of the mothers at least once during pregnancy. The prevalence of emotional problems at 6 and 11 years was 13.6 and 19.9%, respectively. For hyperactivity problems, prevalence was 13.9 and 16.1%, respectively. Intrauterine exposure to acetaminophen increased the odds of having emotional (odds ratio [OR] = 1.47; 95% CI: 1.07–2.02) and hyperactivity/inattention (OR = 1.42; 95% CI: 1.06–1.92) problems in 6-year-old boys. At the age of 11, a small decrease in the effect was observed for both outcomes after adjustment: OR = 1.31 (95% CI: 0.99–1.73) for emotional problems and OR = 1.25 (95% CI: 0.95–1.65) for hyperactivity/inattention in boys. No association for any phenotypes at both ages was observed for girls. Conclusion: The effect of intrauterine exposure to acetaminophen in emotional and hyperactivity symptoms was dependent on sex in a Brazilian cohort. While it seemed to be important for boys, mainly at 6 years of age, for girls, no association was observed.application/pdfengBMC psychiatry. London. Vol. 18 (2018), 368, 11 p.AcetaminofenEfeitos tardios da exposição pré-natalGravidezSintomas comportamentaisEstudos longitudinaisPelotas (RS)Acetaminophen (paracetamol)Prenatal exposureBirth cohortBehavioral symptomsIs intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohortEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001100315.pdf.txt001100315.pdf.txtExtracted Texttext/plain53662http://www.lume.ufrgs.br/bitstream/10183/200537/2/001100315.pdf.txtdff68435be00ed4d309e46089e389de0MD52ORIGINAL001100315.pdfTexto completo (inglês)application/pdf630020http://www.lume.ufrgs.br/bitstream/10183/200537/1/001100315.pdfa02a2be4953c868760dbb62e00295972MD5110183/2005372024-01-31 05:59:24.855401oai:www.lume.ufrgs.br:10183/200537Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-01-31T07:59:24Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort |
title |
Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort |
spellingShingle |
Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort Rodrigues, Luciana Tovo Acetaminofen Efeitos tardios da exposição pré-natal Gravidez Sintomas comportamentais Estudos longitudinais Pelotas (RS) Acetaminophen (paracetamol) Prenatal exposure Birth cohort Behavioral symptoms |
title_short |
Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort |
title_full |
Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort |
title_fullStr |
Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort |
title_full_unstemmed |
Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort |
title_sort |
Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? : findings from the 2004 Pelotas birth cohort |
author |
Rodrigues, Luciana Tovo |
author_facet |
Rodrigues, Luciana Tovo Schneider, Bruna Celestino Silva, Thais Martins da Silva, Bianca Del Ponte da Loret De Mola, Christian Faccini, Lavinia Schuler Vianna, Fernanda Sales Luiz Munhoz, Tiago Neuenfeld Entiauspe, Ludmila Gonçalves Silveira, Mariângela Freitas da Santos, Iná da Silva dos Matijasevich, Alicia Barros, Aluisio Jardim Dornellas de Rohde, Luis Augusto Paim Bertoldi, Andréa Dâmaso |
author_role |
author |
author2 |
Schneider, Bruna Celestino Silva, Thais Martins da Silva, Bianca Del Ponte da Loret De Mola, Christian Faccini, Lavinia Schuler Vianna, Fernanda Sales Luiz Munhoz, Tiago Neuenfeld Entiauspe, Ludmila Gonçalves Silveira, Mariângela Freitas da Santos, Iná da Silva dos Matijasevich, Alicia Barros, Aluisio Jardim Dornellas de Rohde, Luis Augusto Paim Bertoldi, Andréa Dâmaso |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Luciana Tovo Schneider, Bruna Celestino Silva, Thais Martins da Silva, Bianca Del Ponte da Loret De Mola, Christian Faccini, Lavinia Schuler Vianna, Fernanda Sales Luiz Munhoz, Tiago Neuenfeld Entiauspe, Ludmila Gonçalves Silveira, Mariângela Freitas da Santos, Iná da Silva dos Matijasevich, Alicia Barros, Aluisio Jardim Dornellas de Rohde, Luis Augusto Paim Bertoldi, Andréa Dâmaso |
dc.subject.por.fl_str_mv |
Acetaminofen Efeitos tardios da exposição pré-natal Gravidez Sintomas comportamentais Estudos longitudinais Pelotas (RS) |
topic |
Acetaminofen Efeitos tardios da exposição pré-natal Gravidez Sintomas comportamentais Estudos longitudinais Pelotas (RS) Acetaminophen (paracetamol) Prenatal exposure Birth cohort Behavioral symptoms |
dc.subject.eng.fl_str_mv |
Acetaminophen (paracetamol) Prenatal exposure Birth cohort Behavioral symptoms |
description |
Background: Longitudinal studies have consistently reported that prenatal exposure to acetaminophen can to lead to an increased risk of attention deficit-hyperactivity disorder during childhood. This study aimed to investigate the association between intrauterine exposure to acetaminophen and the presence of emotional and behavioral problems at the ages of 6 and 11 years in a low-middle income country. Methods: We performed a prospective longitudinal population-based study using data from the 2004 Pelotas birth cohort. From the 4231 initial cohort participants, 3722 and 3566 children were assessed at 6 and 11 years of age, respectively. The outcomes were assessed using the parent version of Strengths and Difficulties Questionnaire (SDQ). The cut-off points established for the Brazilian population were used to categorize the outcomes. Crude and adjusted odds ratio were obtained through logistic regression. Results: Acetaminophen was used by 27.5% (95% confidence interval [CI]: 26.1–28.9) of the mothers at least once during pregnancy. The prevalence of emotional problems at 6 and 11 years was 13.6 and 19.9%, respectively. For hyperactivity problems, prevalence was 13.9 and 16.1%, respectively. Intrauterine exposure to acetaminophen increased the odds of having emotional (odds ratio [OR] = 1.47; 95% CI: 1.07–2.02) and hyperactivity/inattention (OR = 1.42; 95% CI: 1.06–1.92) problems in 6-year-old boys. At the age of 11, a small decrease in the effect was observed for both outcomes after adjustment: OR = 1.31 (95% CI: 0.99–1.73) for emotional problems and OR = 1.25 (95% CI: 0.95–1.65) for hyperactivity/inattention in boys. No association for any phenotypes at both ages was observed for girls. Conclusion: The effect of intrauterine exposure to acetaminophen in emotional and hyperactivity symptoms was dependent on sex in a Brazilian cohort. While it seemed to be important for boys, mainly at 6 years of age, for girls, no association was observed. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-10-11T03:55:58Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/200537 |
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1471-244X |
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001100315 |
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http://hdl.handle.net/10183/200537 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
BMC psychiatry. London. Vol. 18 (2018), 368, 11 p. |
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openAccess |
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