Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/104136 |
Resumo: | Background: Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes. Methods and Findings: We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up. We evaluated lactate’s association with diabetes risk factors at baseline and estimated the hazard ratio for incident diabetes by quartiles of plasma lactate in 544 incident diabetic cases and 533 non-cases. Plasma lactate showed a graded positive relationship with fasting glucose and insulin (P<0.001). The relative hazard for incident diabetes increased across lactate quartiles (P-trend ≤0.001). Following adjustment for demographic factors, medical history, physical activity, adiposity, and serum lipids, the hazard ratio in the highest quartile was 2.05 times the hazard in the lowest quartile (95% CI: 1.28, 3.28). After including fasting glucose and insulin the association became non-significant. Conclusions: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Future studies should evaluate the temporal relationship between elevated lactate and impaired fasting glucose and insulin resistance. |
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Juraschek, Stephen P.Shantha, Ghanshyam Palamaner SubashChu, Audrey Y.Miller, Edgar R.Guallar, ElliseoHoogeveen, Ron C.Ballantyne, Christie M.Brancati, Frederick L.Schmidt, Maria InêsPankow, James S.Young, J. Hunter2014-10-03T02:12:48Z20131932-6203http://hdl.handle.net/10183/104136000930021Background: Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes. Methods and Findings: We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up. We evaluated lactate’s association with diabetes risk factors at baseline and estimated the hazard ratio for incident diabetes by quartiles of plasma lactate in 544 incident diabetic cases and 533 non-cases. Plasma lactate showed a graded positive relationship with fasting glucose and insulin (P<0.001). The relative hazard for incident diabetes increased across lactate quartiles (P-trend ≤0.001). Following adjustment for demographic factors, medical history, physical activity, adiposity, and serum lipids, the hazard ratio in the highest quartile was 2.05 times the hazard in the lowest quartile (95% CI: 1.28, 3.28). After including fasting glucose and insulin the association became non-significant. Conclusions: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Future studies should evaluate the temporal relationship between elevated lactate and impaired fasting glucose and insulin resistance.application/pdfengPLoS ONE. San Francisco. Vol. 8, no. 1 (Jan. 2013), e55113, 7 p.Ácido lácticoDiabetes mellitusAteroscleroseLactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000930021.pdf000930021.pdfTexto completo (inglês)application/pdf271104http://www.lume.ufrgs.br/bitstream/10183/104136/1/000930021.pdf0ce1a3da8616689cd86874a15070535eMD51TEXT000930021.pdf.txt000930021.pdf.txtExtracted Texttext/plain44352http://www.lume.ufrgs.br/bitstream/10183/104136/2/000930021.pdf.txt496165301573353c63a544472c24fb2fMD52THUMBNAIL000930021.pdf.jpg000930021.pdf.jpgGenerated Thumbnailimage/jpeg2002http://www.lume.ufrgs.br/bitstream/10183/104136/3/000930021.pdf.jpg691f09cc4a0df04a1f2ce9a2c2407830MD5310183/1041362018-10-08 08:47:35.17oai:www.lume.ufrgs.br:10183/104136Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2018-10-08T11:47:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study |
title |
Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study |
spellingShingle |
Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study Juraschek, Stephen P. Ácido láctico Diabetes mellitus Aterosclerose |
title_short |
Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study |
title_full |
Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study |
title_fullStr |
Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study |
title_full_unstemmed |
Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study |
title_sort |
Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study |
author |
Juraschek, Stephen P. |
author_facet |
Juraschek, Stephen P. Shantha, Ghanshyam Palamaner Subash Chu, Audrey Y. Miller, Edgar R. Guallar, Elliseo Hoogeveen, Ron C. Ballantyne, Christie M. Brancati, Frederick L. Schmidt, Maria Inês Pankow, James S. Young, J. Hunter |
author_role |
author |
author2 |
Shantha, Ghanshyam Palamaner Subash Chu, Audrey Y. Miller, Edgar R. Guallar, Elliseo Hoogeveen, Ron C. Ballantyne, Christie M. Brancati, Frederick L. Schmidt, Maria Inês Pankow, James S. Young, J. Hunter |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Juraschek, Stephen P. Shantha, Ghanshyam Palamaner Subash Chu, Audrey Y. Miller, Edgar R. Guallar, Elliseo Hoogeveen, Ron C. Ballantyne, Christie M. Brancati, Frederick L. Schmidt, Maria Inês Pankow, James S. Young, J. Hunter |
dc.subject.por.fl_str_mv |
Ácido láctico Diabetes mellitus Aterosclerose |
topic |
Ácido láctico Diabetes mellitus Aterosclerose |
description |
Background: Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes. Methods and Findings: We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up. We evaluated lactate’s association with diabetes risk factors at baseline and estimated the hazard ratio for incident diabetes by quartiles of plasma lactate in 544 incident diabetic cases and 533 non-cases. Plasma lactate showed a graded positive relationship with fasting glucose and insulin (P<0.001). The relative hazard for incident diabetes increased across lactate quartiles (P-trend ≤0.001). Following adjustment for demographic factors, medical history, physical activity, adiposity, and serum lipids, the hazard ratio in the highest quartile was 2.05 times the hazard in the lowest quartile (95% CI: 1.28, 3.28). After including fasting glucose and insulin the association became non-significant. Conclusions: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Future studies should evaluate the temporal relationship between elevated lactate and impaired fasting glucose and insulin resistance. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
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2014-10-03T02:12:48Z |
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Estrangeiro info:eu-repo/semantics/article |
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1932-6203 |
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000930021 |
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http://hdl.handle.net/10183/104136 |
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eng |
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PLoS ONE. San Francisco. Vol. 8, no. 1 (Jan. 2013), e55113, 7 p. |
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