Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study

Detalhes bibliográficos
Autor(a) principal: Juraschek, Stephen P.
Data de Publicação: 2013
Outros Autores: Shantha, Ghanshyam Palamaner Subash, Chu, Audrey Y., Miller, Edgar R., Guallar, Elliseo, Hoogeveen, Ron C., Ballantyne, Christie M., Brancati, Frederick L., Schmidt, Maria Inês, Pankow, James S., Young, J. Hunter
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/104136
Resumo: Background: Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes. Methods and Findings: We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up. We evaluated lactate’s association with diabetes risk factors at baseline and estimated the hazard ratio for incident diabetes by quartiles of plasma lactate in 544 incident diabetic cases and 533 non-cases. Plasma lactate showed a graded positive relationship with fasting glucose and insulin (P<0.001). The relative hazard for incident diabetes increased across lactate quartiles (P-trend ≤0.001). Following adjustment for demographic factors, medical history, physical activity, adiposity, and serum lipids, the hazard ratio in the highest quartile was 2.05 times the hazard in the lowest quartile (95% CI: 1.28, 3.28). After including fasting glucose and insulin the association became non-significant. Conclusions: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Future studies should evaluate the temporal relationship between elevated lactate and impaired fasting glucose and insulin resistance.
id UFRGS-2_dc651e1cc24d1d49898b295cdba68a64
oai_identifier_str oai:www.lume.ufrgs.br:10183/104136
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Juraschek, Stephen P.Shantha, Ghanshyam Palamaner SubashChu, Audrey Y.Miller, Edgar R.Guallar, ElliseoHoogeveen, Ron C.Ballantyne, Christie M.Brancati, Frederick L.Schmidt, Maria InêsPankow, James S.Young, J. Hunter2014-10-03T02:12:48Z20131932-6203http://hdl.handle.net/10183/104136000930021Background: Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes. Methods and Findings: We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up. We evaluated lactate’s association with diabetes risk factors at baseline and estimated the hazard ratio for incident diabetes by quartiles of plasma lactate in 544 incident diabetic cases and 533 non-cases. Plasma lactate showed a graded positive relationship with fasting glucose and insulin (P<0.001). The relative hazard for incident diabetes increased across lactate quartiles (P-trend ≤0.001). Following adjustment for demographic factors, medical history, physical activity, adiposity, and serum lipids, the hazard ratio in the highest quartile was 2.05 times the hazard in the lowest quartile (95% CI: 1.28, 3.28). After including fasting glucose and insulin the association became non-significant. Conclusions: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Future studies should evaluate the temporal relationship between elevated lactate and impaired fasting glucose and insulin resistance.application/pdfengPLoS ONE. San Francisco. Vol. 8, no. 1 (Jan. 2013), e55113, 7 p.Ácido lácticoDiabetes mellitusAteroscleroseLactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000930021.pdf000930021.pdfTexto completo (inglês)application/pdf271104http://www.lume.ufrgs.br/bitstream/10183/104136/1/000930021.pdf0ce1a3da8616689cd86874a15070535eMD51TEXT000930021.pdf.txt000930021.pdf.txtExtracted Texttext/plain44352http://www.lume.ufrgs.br/bitstream/10183/104136/2/000930021.pdf.txt496165301573353c63a544472c24fb2fMD52THUMBNAIL000930021.pdf.jpg000930021.pdf.jpgGenerated Thumbnailimage/jpeg2002http://www.lume.ufrgs.br/bitstream/10183/104136/3/000930021.pdf.jpg691f09cc4a0df04a1f2ce9a2c2407830MD5310183/1041362018-10-08 08:47:35.17oai:www.lume.ufrgs.br:10183/104136Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2018-10-08T11:47:35Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
title Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
spellingShingle Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
Juraschek, Stephen P.
Ácido láctico
Diabetes mellitus
Aterosclerose
title_short Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
title_full Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
title_fullStr Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
title_full_unstemmed Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
title_sort Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study
author Juraschek, Stephen P.
author_facet Juraschek, Stephen P.
Shantha, Ghanshyam Palamaner Subash
Chu, Audrey Y.
Miller, Edgar R.
Guallar, Elliseo
Hoogeveen, Ron C.
Ballantyne, Christie M.
Brancati, Frederick L.
Schmidt, Maria Inês
Pankow, James S.
Young, J. Hunter
author_role author
author2 Shantha, Ghanshyam Palamaner Subash
Chu, Audrey Y.
Miller, Edgar R.
Guallar, Elliseo
Hoogeveen, Ron C.
Ballantyne, Christie M.
Brancati, Frederick L.
Schmidt, Maria Inês
Pankow, James S.
Young, J. Hunter
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Juraschek, Stephen P.
Shantha, Ghanshyam Palamaner Subash
Chu, Audrey Y.
Miller, Edgar R.
Guallar, Elliseo
Hoogeveen, Ron C.
Ballantyne, Christie M.
Brancati, Frederick L.
Schmidt, Maria Inês
Pankow, James S.
Young, J. Hunter
dc.subject.por.fl_str_mv Ácido láctico
Diabetes mellitus
Aterosclerose
topic Ácido láctico
Diabetes mellitus
Aterosclerose
description Background: Oxidative capacity is decreased in type 2 diabetes. Whether decreased oxidative capacity is a cause or consequence of diabetes is unknown. Our purpose is to evaluate whether lactate, a marker of oxidative capacity, is associated with incident diabetes. Methods and Findings: We conducted a case-cohort study in the Atherosclerosis Risk in Communities (ARIC) study at year 9 of follow-up. We evaluated lactate’s association with diabetes risk factors at baseline and estimated the hazard ratio for incident diabetes by quartiles of plasma lactate in 544 incident diabetic cases and 533 non-cases. Plasma lactate showed a graded positive relationship with fasting glucose and insulin (P<0.001). The relative hazard for incident diabetes increased across lactate quartiles (P-trend ≤0.001). Following adjustment for demographic factors, medical history, physical activity, adiposity, and serum lipids, the hazard ratio in the highest quartile was 2.05 times the hazard in the lowest quartile (95% CI: 1.28, 3.28). After including fasting glucose and insulin the association became non-significant. Conclusions: Lactate, an indicator of oxidative capacity, predicts incident diabetes independent of many other risk factors and is strongly related to markers of insulin resistance. Future studies should evaluate the temporal relationship between elevated lactate and impaired fasting glucose and insulin resistance.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-10-03T02:12:48Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/104136
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.nrb.pt_BR.fl_str_mv 000930021
identifier_str_mv 1932-6203
000930021
url http://hdl.handle.net/10183/104136
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv PLoS ONE. San Francisco. Vol. 8, no. 1 (Jan. 2013), e55113, 7 p.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/104136/1/000930021.pdf
http://www.lume.ufrgs.br/bitstream/10183/104136/2/000930021.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/104136/3/000930021.pdf.jpg
bitstream.checksum.fl_str_mv 0ce1a3da8616689cd86874a15070535e
496165301573353c63a544472c24fb2f
691f09cc4a0df04a1f2ce9a2c2407830
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv lume@ufrgs.br
_version_ 1817724935982809088