Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/29629 |
Resumo: | Occupational therapy (OT) is a profession concerned with promoting health and well-being through occupation, by enabling handicapped people to participate in the activities of everyday life. OT is part of the clinical rehabilitation of progressive genetic neurodegenerative diseases such as spinocerebellar ataxias; however, its effects have never been determined in these diseases. Our aim was to investigate the effect of OT on both physical disabilities and depressive symptoms of spinocerebellar ataxia type 3 (SCA3) patients. Genomically diagnosed SCA3 patients older than 18 years were invited to participate in the study. Disability, as evaluated by functional independence measurement and Barthel incapacitation score, Hamilton Rating Scale for Depression, and World Health Organization Quality of Life questionnaire (WHOQOL-BREF), was determined at baseline and after 3 and 6 months of treatment. Twenty-six patients agreed to participate in the study. All were treated because OT prevents blinding of a control group. Fifteen sessions of rehabilitative OT were applied over a period of 6 months. Difficult access to food, clothing, personal hygiene, and leisure were some of the main disabilities focused by these patients. After this treatment, disability scores and quality of life were stable, and the Hamilton scores for depression improved. Since no medication was started up to 6 months before or during OT, this improvement was related to our intervention. No association was found between these endpoints and a CAG tract of the MJD1 gene (CAGn), age, age of onset, or neurological scores at baseline (Spearman test). Although the possibly temporary stabilization of the downhill disabilities as an effect of OT remains to be established, its clear effect on depressive symptoms confirms the recommendation of OT to any patient with SCA3 or spinocerebellar ataxia. |
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Silva, Renata Cristina Rocha daSaute, Jonas Alex MoralesSilva, Andrew Chaves Feitosa daCoutinho, Ana Carolina de OliveiraPereira, Maria Luiza SaraivaJardim, Laura Bannach2011-06-18T06:02:11Z20100100-879Xhttp://hdl.handle.net/10183/29629000747810Occupational therapy (OT) is a profession concerned with promoting health and well-being through occupation, by enabling handicapped people to participate in the activities of everyday life. OT is part of the clinical rehabilitation of progressive genetic neurodegenerative diseases such as spinocerebellar ataxias; however, its effects have never been determined in these diseases. Our aim was to investigate the effect of OT on both physical disabilities and depressive symptoms of spinocerebellar ataxia type 3 (SCA3) patients. Genomically diagnosed SCA3 patients older than 18 years were invited to participate in the study. Disability, as evaluated by functional independence measurement and Barthel incapacitation score, Hamilton Rating Scale for Depression, and World Health Organization Quality of Life questionnaire (WHOQOL-BREF), was determined at baseline and after 3 and 6 months of treatment. Twenty-six patients agreed to participate in the study. All were treated because OT prevents blinding of a control group. Fifteen sessions of rehabilitative OT were applied over a period of 6 months. Difficult access to food, clothing, personal hygiene, and leisure were some of the main disabilities focused by these patients. After this treatment, disability scores and quality of life were stable, and the Hamilton scores for depression improved. Since no medication was started up to 6 months before or during OT, this improvement was related to our intervention. No association was found between these endpoints and a CAG tract of the MJD1 gene (CAGn), age, age of onset, or neurological scores at baseline (Spearman test). Although the possibly temporary stabilization of the downhill disabilities as an effect of OT remains to be established, its clear effect on depressive symptoms confirms the recommendation of OT to any patient with SCA3 or spinocerebellar ataxia.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 43, n. 6 (jun. 2010), p. 537-542Doença de Machado-JosephTerapia ocupacionalEnsaio clínicoSpinocerebellar ataxia 3Occupational therapyRehabilitationDepressionMachado-Joseph diseasePolyglutamine diseasesOccupational therapy in spinocerebellar ataxia type 3 : an open-label trialinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000747810.pdf000747810.pdfTexto completo (inglês)application/pdf587389http://www.lume.ufrgs.br/bitstream/10183/29629/1/000747810.pdfbf37c49e616bb49f1dc06188e55a56ddMD51TEXT000747810.pdf.txt000747810.pdf.txtExtracted Texttext/plain25972http://www.lume.ufrgs.br/bitstream/10183/29629/2/000747810.pdf.txt028c1b659b57a37ad54b50beada5627fMD52THUMBNAIL000747810.pdf.jpg000747810.pdf.jpgGenerated Thumbnailimage/jpeg2026http://www.lume.ufrgs.br/bitstream/10183/29629/3/000747810.pdf.jpg41c2b190b3525eb422c0438eecc5ae0fMD5310183/296292023-08-18 03:39:52.321378oai:www.lume.ufrgs.br:10183/29629Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-18T06:39:52Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial |
title |
Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial |
spellingShingle |
Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial Silva, Renata Cristina Rocha da Doença de Machado-Joseph Terapia ocupacional Ensaio clínico Spinocerebellar ataxia 3 Occupational therapy Rehabilitation Depression Machado-Joseph disease Polyglutamine diseases |
title_short |
Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial |
title_full |
Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial |
title_fullStr |
Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial |
title_full_unstemmed |
Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial |
title_sort |
Occupational therapy in spinocerebellar ataxia type 3 : an open-label trial |
author |
Silva, Renata Cristina Rocha da |
author_facet |
Silva, Renata Cristina Rocha da Saute, Jonas Alex Morales Silva, Andrew Chaves Feitosa da Coutinho, Ana Carolina de Oliveira Pereira, Maria Luiza Saraiva Jardim, Laura Bannach |
author_role |
author |
author2 |
Saute, Jonas Alex Morales Silva, Andrew Chaves Feitosa da Coutinho, Ana Carolina de Oliveira Pereira, Maria Luiza Saraiva Jardim, Laura Bannach |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Renata Cristina Rocha da Saute, Jonas Alex Morales Silva, Andrew Chaves Feitosa da Coutinho, Ana Carolina de Oliveira Pereira, Maria Luiza Saraiva Jardim, Laura Bannach |
dc.subject.por.fl_str_mv |
Doença de Machado-Joseph Terapia ocupacional Ensaio clínico |
topic |
Doença de Machado-Joseph Terapia ocupacional Ensaio clínico Spinocerebellar ataxia 3 Occupational therapy Rehabilitation Depression Machado-Joseph disease Polyglutamine diseases |
dc.subject.eng.fl_str_mv |
Spinocerebellar ataxia 3 Occupational therapy Rehabilitation Depression Machado-Joseph disease Polyglutamine diseases |
description |
Occupational therapy (OT) is a profession concerned with promoting health and well-being through occupation, by enabling handicapped people to participate in the activities of everyday life. OT is part of the clinical rehabilitation of progressive genetic neurodegenerative diseases such as spinocerebellar ataxias; however, its effects have never been determined in these diseases. Our aim was to investigate the effect of OT on both physical disabilities and depressive symptoms of spinocerebellar ataxia type 3 (SCA3) patients. Genomically diagnosed SCA3 patients older than 18 years were invited to participate in the study. Disability, as evaluated by functional independence measurement and Barthel incapacitation score, Hamilton Rating Scale for Depression, and World Health Organization Quality of Life questionnaire (WHOQOL-BREF), was determined at baseline and after 3 and 6 months of treatment. Twenty-six patients agreed to participate in the study. All were treated because OT prevents blinding of a control group. Fifteen sessions of rehabilitative OT were applied over a period of 6 months. Difficult access to food, clothing, personal hygiene, and leisure were some of the main disabilities focused by these patients. After this treatment, disability scores and quality of life were stable, and the Hamilton scores for depression improved. Since no medication was started up to 6 months before or during OT, this improvement was related to our intervention. No association was found between these endpoints and a CAG tract of the MJD1 gene (CAGn), age, age of onset, or neurological scores at baseline (Spearman test). Although the possibly temporary stabilization of the downhill disabilities as an effect of OT remains to be established, its clear effect on depressive symptoms confirms the recommendation of OT to any patient with SCA3 or spinocerebellar ataxia. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2011-06-18T06:02:11Z |
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0100-879X |
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000747810 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 43, n. 6 (jun. 2010), p. 537-542 |
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